# Two sample MR report

## Asthma || id:ebi-a-GCST90018795 against Type 2 diabetes (adjusted for BMI) || id:ebi-a-GCST90093110

Date: 28 January, 2026

### Results from two sample MR:

method | nsnp | b | se | pval
--- | --- | --- | --- | ---
MR Egger | 105 | -0.062 | 0.111 | 0.578
Weighted median | 105 | -0.010 | 0.052 | 0.851
Inverse variance weighted | 105 | 0.006 | 0.040 | 0.876
Simple mode | 105 | 0.078 | 0.113 | 0.489
Weighted mode | 105 | 0.032 | 0.074 | 0.661

### Heterogeneity tests

method | Q | Q_df | Q_pval
--- | --- | --- | ---
MR Egger | 136 | 103 | 0.017
Inverse variance weighted | 136 | 104 | 0.018

### Test for directional horizontal pleiotropy

egger_intercept | se | pval
--- | --- | ---
0.004 | 0.006 | 0.512

### Test that the exposure is upstream of the outcome

snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval
--- | --- | --- | ---
0 | 0 | TRUE | 0.874

Note - R^2 values are approximate

### Forest plot of single SNP MR

### Comparison of results using different MR methods

### Funnel plot

### Leave-one-out sensitivity analysis