rsid	trait	chr	pos	p	OR or BETA	95% CI (TEXT)	MAPPED_GENE	PUBMEDID	FIRST AUTHOR	JOURNAL	Sample	STUDY ACCESSION
rs17293632	ulcerative colitis	15	67150258	2e-08	NA		SMAD3	28067908	de Lange KM	Nat Genet	12,366 European and unknown ancestry cases, 33,609 European and unknown ancestry controls	GCST004133
rs17293632	inflammatory bowel disease	15	67150258	3e-21	NA		SMAD3	28067908	de Lange KM	Nat Genet	25,042 European and unknown ancestry cases, 34,915 European and unknown ancestry controls	GCST004131
rs2070901	allergic disease	1	161215268	1e-11	1.039	[1.03-1.05]	FCER1G	29083406	Ferreira MA	Nat Genet	180,129 European ancestry cases, 180,709 European ancestry controls	GCST005038
rs34290285	allergic disease	2	241759225	4e-33	1.082	[1.07-1.09]	D2HGDH	29083406	Ferreira MA	Nat Genet	180,129 European ancestry cases, 180,709 European ancestry controls	GCST005038
rs5743618	allergic disease	4	38797027	3e-58	1.1	[1.09-1.11]	TLR1	29083406	Ferreira MA	Nat Genet	180,129 European ancestry cases, 180,709 European ancestry controls	GCST005038
rs10486391	allergic disease	7	20336395	7e-09	1.03	[1.02-1.04]	ITGB8	29083406	Ferreira MA	Nat Genet	180,129 European ancestry cases, 180,709 European ancestry controls	GCST005038
rs1837253	allergic disease	5	111066174	2e-31	1.07	[1.06-1.08]	BCLAF1P1 - TSLP	29083406	Ferreira MA	Nat Genet	180,129 European ancestry cases, 180,709 European ancestry controls	GCST005038
rs6679677	monokine induced by gamma interferon measurement	1	113761186	9e-07	0.162	[0.098-0.226] SD units decrease	PHTF1 - RSBN1	27989323	Ahola-Olli AV	Am J Hum Genet	3,685 Finnish ancestry individuals	GCST004435
rs6679677	systemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, rheumatoid factor negative, oligoarticular juvenile idiopathic arthritis	1	113761186	3e-25	1.59	[1.45-1.73]	PHTF1 - RSBN1	23603761	Hinks A	Nat Genet	2,816 European ancestry cases, 13,056 European ancestry controls	GCST005528
rs12122629	mosquito bite reaction itch intensity measurement, mosquito bite reaction size measurement	1	152101640	4e-06	0.0362438	[0.021-0.052] unit increase	TCHHL1 - TCHH	28199695	Jones AV	Hum Mol Genet	41,355 European ancestry men and 43,369 European ancestry women	GCST004862
rs12122629	mosquito bite reaction itch intensity measurement	1	152101640	3e-07	0.0465576	[0.029-0.064] unit increase	TCHHL1 - TCHH	28199695	Jones AV	Hum Mol Genet	84,724 European ancestry individuals	GCST004861
rs17293632	Crohn's disease	15	67150258	2e-19	NA		SMAD3	28067908	de Lange KM	Nat Genet	12,194 European and unknown ancestry cases, 28,072 European and unknown ancestry controls	GCST004132
rs6687430	grip strength measurement	1	10573188	6e-11	0.1423	[0.1-0.185] kg increase	PEX14	29313844	Willems SM	Nat Commun	142,035 European ancestry individuals	GCST005235
rs6679677	systemic lupus erythematosus	1	113761186	1e-15	1.39	[NR]	PHTF1 - RSBN1	26502338	Bentham J	Nat Genet	5,201 European ancestry cases, 9,066 European ancestry controls	GCST003156
rs2070901	aggressive periodontitis	1	161215268	4e-06	1.29	[1.16-1.44]	FCER1G	28449029	Munz M	Hum Mol Genet	851 European ancestry cases, 6,836 European ancestry controls	GCST004303
rs1837253	asthma	5	111066174	7e-08	NA		BCLAF1P1 - TSLP	27611488	Almoguera B	Am J Respir Crit Care Med	819 African American non-allergic asthma cases, 2,218 African American allergic asthma cases 4,360 African American controls, 808 European American non-allergic asthma cases, 1,464 European American allergic asthma cases, 11,975 European American controls	GCST003831
rs1837253	asthma	5	111066174	4e-07	NA		BCLAF1P1 - TSLP	27611488	Almoguera B	Am J Respir Crit Care Med	819 African American non-allergic asthma cases, 2,218 African American allergic asthma cases 4,360 African American controls, 808 European American non-allergic asthma cases, 1,464 European American allergic asthma cases, 11,975 European American controls	GCST003831
rs10995245	narcolepsy-cataplexy syndrome	10	62631615	3e-07	1.2	[1.09-1.31]	LINC02929	23459209	Faraco J	PLoS Genet	1,886 European ancestry cases, 10,421 European ancestry controls	GCST005522
rs992969	asthma	9	6209697	7e-20	1.1627907	[1.14-1.2]	GTF3AP1 - IL33	29273806	Demenais F	Nat Genet	19,954 European ancestry cases, 107,715 European ancestry controls, 2,149 African ancestry cases, 6,055 African ancestry controls, 1,239 Japanese ancestry cases, 3,976 Japanese ancestry controls, 606 Latino cases, 792 Latino controls	GCST005212
rs992969	asthma	9	6209697	4e-29	1.1764705	[1.14-1.22]	GTF3AP1 - IL33	29273806	Demenais F	Nat Genet	19,954 European ancestry cases, 107,715 European ancestry controls	GCST006862
rs17293632	asthma	15	67150258	9e-16	0.12	[0.1-0.14] unit increase	SMAD3	29273806	Demenais F	Nat Genet	19,954 European ancestry cases, 107,715 European ancestry controls	GCST006862
rs72837816	BMI-adjusted waist-hip ratio	2	111159291	1e-13	0.0248	[0.018-0.031] unit increase	BCL2L11, MIR4435-2HG	30239722	Pulit SL	Hum Mol Genet	379,501 European ancestry female individuals	GCST008994
rs6679677	temporal arteritis	1	113761186	1e-06	1.39	[1.22-1.58]	PHTF1 - RSBN1	25817017	Carmona FD	Am J Hum Genet	1,651 European ancestry cases, 15,306 European ancestry controls	GCST006198
rs34290285	asthma	2	241759225	4e-42	1.1011212	[1.09-1.12]	D2HGDH	31619474	Zhu Z	Eur Respir J	46,802 European ancestry cases, 347,481 European ancestry controls	GCST008916
rs992969	asthma	9	6209697	3e-64	1.127365	[1.11-1.14]	GTF3AP1 - IL33	31619474	Zhu Z	Eur Respir J	46,802 European ancestry cases, 347,481 European ancestry controls	GCST008916
rs2070901	asthma	1	161215268	2e-08	1.03959	[1.03-1.05]	FCER1G	31619474	Zhu Z	Eur Respir J	46,802 European ancestry cases, 347,481 European ancestry controls	GCST008916
rs76181804	asthma	1	198632575	3e-08	1.0528406	[1.03-1.07]	ATP6V1G3 - PTPRC	31619474	Zhu Z	Eur Respir J	46,802 European ancestry cases, 347,481 European ancestry controls	GCST008916
rs13263709	asthma	8	80374940	2e-24	1.0685416	[1.06-1.08]	RPL13AP18 - RNU6-1213P	31619474	Zhu Z	Eur Respir J	46,802 European ancestry cases, 347,481 European ancestry controls	GCST008916
rs2834787	asthma	21	35130261	2e-11	1.057204	[1.04-1.07]	RUNX1	31619474	Zhu Z	Eur Respir J	46,802 European ancestry cases, 347,481 European ancestry controls	GCST008916
rs1837253	asthma	5	111066174	1e-51	1.1119064	[1.1-1.13]	BCLAF1P1 - TSLP	31619474	Zhu Z	Eur Respir J	46,802 European ancestry cases, 347,481 European ancestry controls	GCST008916
rs6687430	hair color	1	10573188	1e-08	1.045	NR	PEX14	30531825	Morgan MD	Nat Commun	39,397 British ancestry blond hair individuals, 283,920 British ancestry brown or black hair individuals	GCST006988
rs6679677	systemic scleroderma, rheumatoid arthritis, myositis, systemic lupus erythematosus	1	113761186	2e-28	1.34	[1.21-1.49]	PHTF1 - RSBN1	30573655	Acosta-Herrera M	Ann Rheum Dis	up to 4,595 European ancestry rheumatoid arthritis cases, up to 3,154 European ancestry systemic lupus erythematosus cases, up to 2,281 European ancestry systemic sclerosis cases, up to 1,674 European ancestry idiopathic inflammatory myopathy cases, 19,704 European ancestry controls	GCST007278
rs1837253	asthma	5	111066174	2e-20	0.140412	[0.11-0.17] unit decrease	BCLAF1P1 - TSLP	29785011	Zhu Z	Nat Genet	14,085 European ancestry cases, 76,768 European ancestry controls	GCST007562
rs1837253	asthma, allergic disease	5	111066174	4e-21	1.0752687		BCLAF1P1 - TSLP	29785011	Zhu Z	Nat Genet	14,085 European asthma cases, 25,685 European ancestry allergic diseases cases, 76,768 European ancestry controls	GCST007564
rs34290285	asthma, allergic disease	2	241759225	5e-17	1.0752687		D2HGDH	29785011	Zhu Z	Nat Genet	14,085 European asthma cases, 25,685 European ancestry allergic diseases cases, 76,768 European ancestry controls	GCST007564
rs34290285	asthma, allergic disease	2	241759225	2e-15	1.098901	[1.08-1.12]	D2HGDH	29785011	Zhu Z	Nat Genet	25,685 European ancestry allergic diseases cases, 76,768 European ancestry controls	GCST007563
rs11154801	multiple sclerosis	6	135418217	2e-20	1.12		AHI1	24076602	Beecham AH	Nat Genet	14,498 European ancestry cases, 24,091 European ancestry controls	GCST005531
rs166840	physical activity measurement	17	19896385	3e-11	1.03		ULK2 - AKAP10	29899525	Klimentidis YC	Int J Obes (Lond)	124,842 European ancestry active cases, 225,650 European ancestry inactive controls	GCST006100
rs6679677	keratinocyte carcinoma	1	113761186	7e-11	1.1	[1.07-1.13]	PHTF1 - RSBN1	31174203	Liyanage UE	Hum Mol Genet	at least 18,538 European ancestry cases, at least 340,302 European ancestry controls	GCST008870
rs1837253	Churg-Strauss syndrome	5	111066174	5e-11	0.42	NR unit increase	BCLAF1P1 - TSLP	31719529	Lyons PA	Nat Commun	534 European ancestry cases, 6,688 European ancestry controls	GCST009250
rs10797119	triglyceride measurement	9	89587580	5e-15	0.0156972	[0.012-0.02] unit decrease	SEMA4D - GADD45G	32203549	Richardson TG	PLoS Med	441,016 European ancestry individuals	GCST010244
rs34290285	eosinophil count	2	241759225	3e-93	NA		D2HGDH	30595370	Kichaev G	Am J Hum Genet	approximately 440,000 European ancestry individuals	GCST007065
rs34712979	forced expiratory volume	4	105897896	3e-20	0.201	[0.16-0.24] unit increase	NPNT	26423011	Wain LV	Lancet Respir Med	19,493 European ancestry individuals with low FEV1 measurements, 9,808 European ancestry individuals with high FEV1 measurements	GCST008664
rs34712979	forced expiratory volume	4	105897896	1e-08	1.18	[1.11-1.25]	NPNT	26423011	Wain LV	Lancet Respir Med	9,748 European ancestry individuals with low FEV1 measurements, 4,906 European ancestry individuals with high FEV1 measurements	GCST008659
rs34712979	forced expiratory volume	4	105897896	3e-08	1.138	[1.087-1.191]	NPNT	26423011	Wain LV	Lancet Respir Med	9,745 European ancestry individuals with low FEV1 measurements, 9,827 European ancestry individuals with average FEV1 measurements	GCST008663
rs34712979	forced expiratory volume	4	105897896	1e-15	1.27	[1.20-1.34]	NPNT	26423011	Wain LV	Lancet Respir Med	9,745 European ancestry individuals with low FEV1 measurements, 4,902 European ancestry individuals with high FEV1 measurements	GCST008662
rs6679677	event free survival time, type 1 diabetes mellitus, autoantibody measurement	1	113761186	2e-06	1.46		PHTF1 - RSBN1	29310926	Sharma A	J Autoimmun	5,806 European ancestry children	GCST006197
rs6679677	event free survival time, type 1 diabetes mellitus, autoantibody measurement	1	113761186	2e-06	1.592		PHTF1 - RSBN1	29310926	Sharma A	J Autoimmun	5,806 European ancestry children	GCST006197
rs34290285	eosinophil count	2	241759225	6e-94	NA		D2HGDH	32888493	Chen MH	Cell	583,850 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals	GCST90002302
rs12253380	eosinophil count	10	8898431	2e-20	NA		LINC02676	30595370	Kichaev G	Am J Hum Genet	approximately 440,000 European ancestry individuals	GCST007065
rs17293632	eosinophil count	15	67150258	3e-38	NA		SMAD3	30595370	Kichaev G	Am J Hum Genet	approximately 440,000 European ancestry individuals	GCST007065
rs11903152	erythrocyte count	2	230309590	1e-08	NA		SP140	30595370	Kichaev G	Am J Hum Genet	approximately 445,000 European ancestry individuals	GCST007069
rs34290285	eosinophil count	2	241759225	2e-70	0.044891234	[0.04-0.05] unit decrease	D2HGDH	32888494	Vuckovic D	Cell	408,112 British individuals	GCST90002381
rs6679677	basophil percentage of leukocytes	1	113761186	2e-16	0.030244133	[0.023-0.037] unit increase	PHTF1 - RSBN1	32888494	Vuckovic D	Cell	408,112 British individuals	GCST90002380
rs346835	eosinophil count	2	8298563	8e-37	0.02669	[0.023-0.031] SD unit decrease	LINC00299	32888493	Chen MH	Cell	474,237 European ancestry individuals	GCST90002298
rs34290285	eosinophil count	2	241759225	5e-91	0.045886	[0.041-0.05] SD unit decrease	D2HGDH	32888493	Chen MH	Cell	474,237 European ancestry individuals	GCST90002298
rs17293632	eosinophil count	15	67150258	9e-37	0.02962	[0.025-0.034] SD unit increase	SMAD3	32888493	Chen MH	Cell	474,237 European ancestry individuals	GCST90002298
rs1837253	eosinophil count	5	111066174	1e-14	0.020959023	[0.016-0.026] unit increase	BCLAF1P1 - TSLP	32888494	Vuckovic D	Cell	408,112 British individuals	GCST90002381
rs34290285	asthma	2	241759225	2e-21	NA		D2HGDH	31669095	Zhu Z	J Allergy Clin Immunol	28,862 European ancestry cases, 422,048 European ancestry controls	GCST009845
rs1837253	asthma	5	111066174	5e-22	NA		BCLAF1P1 - TSLP	31669095	Zhu Z	J Allergy Clin Immunol	28,862 European ancestry cases, 422,048 European ancestry controls	GCST009845
rs10486391	asthma	7	20336395	4e-09	NA		ITGB8	31669095	Zhu Z	J Allergy Clin Immunol	28,862 European ancestry cases, 422,048 European ancestry controls	GCST009845
rs992969	asthma	9	6209697	2e-37	NA		GTF3AP1 - IL33	31669095	Zhu Z	J Allergy Clin Immunol	28,862 European ancestry cases, 422,048 European ancestry controls	GCST009845
rs12935657	atopic asthma	16	11125184	1e-25	NA		CLEC16A	31669095	Zhu Z	J Allergy Clin Immunol	23,982 European ancestry cases, 393,169 European ancestry controls	GCST009850
rs2834787	atopic asthma	21	35130261	3e-08	NA		RUNX1	31669095	Zhu Z	J Allergy Clin Immunol	23,982 European ancestry cases, 393,169 European ancestry controls	GCST009850
rs2070901	childhood onset asthma	1	161215268	3e-09	NA		FCER1G	31669095	Zhu Z	J Allergy Clin Immunol	13,435 European ancestry cases, 393,186 European ancestry controls	GCST009841
rs2070901	atopic asthma	1	161215268	6e-09	NA		FCER1G	31669095	Zhu Z	J Allergy Clin Immunol	23,982 European ancestry cases, 393,169 European ancestry controls	GCST009850
rs34290285	atopic asthma	2	241759225	2e-41	NA		D2HGDH	31669095	Zhu Z	J Allergy Clin Immunol	23,982 European ancestry cases, 393,169 European ancestry controls	GCST009850
rs1837253	atopic asthma	5	111066174	2e-35	NA		BCLAF1P1 - TSLP	31669095	Zhu Z	J Allergy Clin Immunol	23,982 European ancestry cases, 393,169 European ancestry controls	GCST009850
rs34290285	childhood onset asthma	2	241759225	2e-34	NA		D2HGDH	31669095	Zhu Z	J Allergy Clin Immunol	13,435 European ancestry cases, 393,186 European ancestry controls	GCST009841
rs1837253	childhood onset asthma	5	111066174	3e-35	NA		BCLAF1P1 - TSLP	31669095	Zhu Z	J Allergy Clin Immunol	13,435 European ancestry cases, 393,186 European ancestry controls	GCST009841
rs5743618	allergic rhinitis	4	38797027	4e-27	1.1111112	[1.09-1.12]	TLR1	30013184	Waage J	Nat Genet	59,762 European and unknown ancestry cases, 152,358 European and unknown ancestry controls	GCST006409
rs41285280	atopic asthma	6	127970504	6e-15	NA		PTPRK	31669095	Zhu Z	J Allergy Clin Immunol	23,982 European ancestry cases, 393,169 European ancestry controls	GCST009850
rs13263709	atopic asthma	8	80374940	1e-16	NA		RPL13AP18 - RNU6-1213P	31669095	Zhu Z	J Allergy Clin Immunol	23,982 European ancestry cases, 393,169 European ancestry controls	GCST009850
rs17293632	atopic asthma	15	67150258	4e-27	NA		SMAD3	31669095	Zhu Z	J Allergy Clin Immunol	23,982 European ancestry cases, 393,169 European ancestry controls	GCST009850
rs77665773	asthma, Eczematoid dermatitis, allergic rhinitis	5	14700894	3e-10	1.075	[1.052-1.099]	OTULIN - ANKH	31361310	Johansson A	Hum Mol Genet	106,772 European ancestry cases, 239,773 European ancestry controls	GCST009716
rs12122629	asthma, Eczematoid dermatitis, allergic rhinitis	1	152101640	1e-24	1.146	[1.118-1.176]	TCHHL1 - TCHH	31361310	Johansson A	Hum Mol Genet	106,772 European ancestry cases, 239,773 European ancestry controls	GCST009716
rs34290285	asthma, Eczematoid dermatitis, allergic rhinitis	2	241759225	6e-58	1.1064395	[1.09-1.12]	D2HGDH	31361310	Johansson A	Hum Mol Genet	106,772 European ancestry cases, 239,773 European ancestry controls	GCST009716
rs12935657	asthma, Eczematoid dermatitis, allergic rhinitis	16	11125184	6e-45	1.0945709	[1.08-1.11]	CLEC16A	31361310	Johansson A	Hum Mol Genet	106,772 European ancestry cases, 239,773 European ancestry controls	GCST009716
rs10995245	asthma, Eczematoid dermatitis, allergic rhinitis	10	62631615	2e-09	1.035	[1.024-1.046]	LINC02929	31361310	Johansson A	Hum Mol Genet	106,772 European ancestry cases, 239,773 European ancestry controls	GCST009716
rs2070901	asthma, Eczematoid dermatitis, allergic rhinitis	1	161215268	6e-12	1.043	[1.031-1.056]	FCER1G	31361310	Johansson A	Hum Mol Genet	106,772 European ancestry cases, 239,773 European ancestry controls	GCST009716
rs346835	eosinophil percentage of leukocytes	2	8298563	4e-32	0.027631028	[0.023-0.032] unit decrease	LINC00299	32888494	Vuckovic D	Cell	408,112 British individuals	GCST90002382
rs34290285	eosinophil percentage of leukocytes	2	241759225	4e-69	0.044514384	[0.04-0.049] unit decrease	D2HGDH	32888494	Vuckovic D	Cell	408,112 British individuals	GCST90002382
rs2834787	eosinophil percentage of leukocytes	21	35130261	2e-13	0.022791006	[0.017-0.029] unit increase	RUNX1	32888494	Vuckovic D	Cell	408,112 British individuals	GCST90002382
rs34290285	asthma	2	241759225	1e-44	NA		D2HGDH	31361310	Johansson A	Hum Mol Genet	41,926 European ancestry cases, 239,773 European ancestry controls	GCST009720
rs1837253	asthma	5	111066174	4e-44	NA		BCLAF1P1 - TSLP	31361310	Johansson A	Hum Mol Genet	41,926 European ancestry cases, 239,773 European ancestry controls	GCST009720
rs13263709	asthma	8	80374940	8e-22	NA		RPL13AP18 - RNU6-1213P	31361310	Johansson A	Hum Mol Genet	41,926 European ancestry cases, 239,773 European ancestry controls	GCST009720
rs1837253	eosinophil percentage of leukocytes	5	111066174	8e-16	0.0218103	[0.017-0.027] unit increase	BCLAF1P1 - TSLP	32888494	Vuckovic D	Cell	408,112 British individuals	GCST90002382
rs17293632	eosinophil percentage of leukocytes	15	67150258	2e-33	0.031639926	[0.026-0.037] unit increase	SMAD3	32888494	Vuckovic D	Cell	408,112 British individuals	GCST90002382
rs77665773	Eczematoid dermatitis, allergic rhinitis	5	14700894	1e-08	1.074	[1.049-1.1]	OTULIN - ANKH	31361310	Johansson A	Hum Mol Genet	84,034 European ancestry cases, 239,773 European ancestry controls	GCST009717
rs17293632	Eczematoid dermatitis, allergic rhinitis	15	67150258	6e-25	1.074	[1.06-1.088]	SMAD3	31361310	Johansson A	Hum Mol Genet	84,034 European ancestry cases, 239,773 European ancestry controls	GCST009717
rs12122629	Eczematoid dermatitis, allergic rhinitis	1	152101640	8e-25	1.16	[1.129-1.192]	TCHHL1 - TCHH	31361310	Johansson A	Hum Mol Genet	84,034 European ancestry cases, 239,773 European ancestry controls	GCST009717
rs17293632	eosinophil count	15	67150258	1e-28	0.02932875	[0.024-0.035] unit increase	SMAD3	32888494	Vuckovic D	Cell	408,112 British individuals	GCST90002381
rs4807440	leukocyte count	19	1026478	6e-25	NA		RNU6-2 - CNN2	30595370	Kichaev G	Am J Hum Genet	approximately 444,000 European ancestry individuals	GCST007070
rs17293632	eosinophil count	15	67150258	1e-33	NA		SMAD3	32888493	Chen MH	Cell	583,850 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals	GCST90002302
rs34290285	Eczematoid dermatitis	2	241759225	3e-09	1.1244799	[1.08-1.17]	D2HGDH	31361310	Johansson A	Hum Mol Genet	7,884 European ancestry cases, 239,773 European ancestry controls	GCST009718
rs34290285	allergic rhinitis	2	241759225	3e-24	1.1422044	[1.11-1.17]	D2HGDH	31361310	Johansson A	Hum Mol Genet	18,915 European ancestry cases, 239,773 European ancestry controls	GCST009719
rs12935657	allergic rhinitis	16	11125184	8e-15	1.1082788	[1.08-1.14]	CLEC16A	31361310	Johansson A	Hum Mol Genet	18,915 European ancestry cases, 239,773 European ancestry controls	GCST009719
rs2070901	allergic rhinitis	1	161215268	4e-10	1.081	[1.056-1.107]	FCER1G	31361310	Johansson A	Hum Mol Genet	18,915 European ancestry cases, 239,773 European ancestry controls	GCST009719
rs1904522	allergic rhinitis	4	122415763	5e-15	1.096	[1.072-1.121]	ADAD1	31361310	Johansson A	Hum Mol Genet	18,915 European ancestry cases, 239,773 European ancestry controls	GCST009719
rs17293632	allergic rhinitis	15	67150258	9e-16	1.109	[1.082-1.136]	SMAD3	31361310	Johansson A	Hum Mol Genet	18,915 European ancestry cases, 239,773 European ancestry controls	GCST009719
rs2070901	Eczematoid dermatitis, allergic rhinitis	1	161215268	7e-13	1.049	[1.036-1.062]	FCER1G	31361310	Johansson A	Hum Mol Genet	84,034 European ancestry cases, 239,773 European ancestry controls	GCST009717
rs1702877	intelligence	12	56034024	6e-12	6.874	z-score increase	IKZF4	29844566	Davies G	Nat Commun	up to 300,486 European ancestry individuals	GCST006269
rs34290285	Eczematoid dermatitis, allergic rhinitis	2	241759225	2e-51	1.1095084	[1.1-1.12]	D2HGDH	31361310	Johansson A	Hum Mol Genet	84,034 European ancestry cases, 239,773 European ancestry controls	GCST009717
rs12935657	Eczematoid dermatitis, allergic rhinitis	16	11125184	1e-38	1.0955303	[1.08-1.11]	CLEC16A	31361310	Johansson A	Hum Mol Genet	84,034 European ancestry cases, 239,773 European ancestry controls	GCST009717
rs1837253	Eczematoid dermatitis, allergic rhinitis	5	111066174	3e-19	1.0629252	[1.05-1.08]	BCLAF1P1 - TSLP	31361310	Johansson A	Hum Mol Genet	84,034 European ancestry cases, 239,773 European ancestry controls	GCST009717
rs346835	eosinophil count	2	8298563	1e-29	0.02643847	[0.022-0.031] unit decrease	LINC00299	32888494	Vuckovic D	Cell	408,112 British individuals	GCST90002381
rs12935657	asthma	16	11125184	6e-33	NA		CLEC16A	31361310	Johansson A	Hum Mol Genet	41,926 European ancestry cases, 239,773 European ancestry controls	GCST009720
rs2070901	Eczematoid dermatitis	1	161215268	1e-14	NA		FCER1G	30595370	Kichaev G	Am J Hum Genet	approximately 459,000 European ancestry individuals	GCST007075
rs34290285	Eczematoid dermatitis	2	241759225	1e-58	NA		D2HGDH	30595370	Kichaev G	Am J Hum Genet	approximately 459,000 European ancestry individuals	GCST007075
rs34712979	vital capacity	4	105897896	1e-21	0.0261	[0.021-0.031] unit decrease	NPNT	30804560	Shrine N	Nat Genet	321,047 European ancestry individuals	GCST007429
rs5743618	Eczematoid dermatitis	4	38797027	4e-114	NA		TLR1	30595370	Kichaev G	Am J Hum Genet	approximately 459,000 European ancestry individuals	GCST007075
rs1904522	Eczematoid dermatitis	4	122415763	1e-37	NA		ADAD1	30595370	Kichaev G	Am J Hum Genet	approximately 459,000 European ancestry individuals	GCST007075
rs34290285	respiratory system disease	2	241759225	1e-39	NA		D2HGDH	30595370	Kichaev G	Am J Hum Genet	approximately 459,000 European ancestry individuals	GCST007076
rs5743618	respiratory system disease	4	38797027	1e-19	NA		TLR1	30595370	Kichaev G	Am J Hum Genet	approximately 459,000 European ancestry individuals	GCST007076
rs34712979	respiratory system disease	4	105897896	2e-09	NA		NPNT	30595370	Kichaev G	Am J Hum Genet	approximately 459,000 European ancestry individuals	GCST007076
rs6687430	respiratory system disease	1	10573188	3e-09	NA		PEX14	30595370	Kichaev G	Am J Hum Genet	approximately 459,000 European ancestry individuals	GCST007076
rs10797119	chronotype measurement	9	89587580	3e-09	0.013	[0.0091-0.0169] unit decrease	SEMA4D - GADD45G	30804565	Jansen PR	Nat Genet	434,835 European ancestry individuals	GCST007983
rs34712979	chronic obstructive pulmonary disease	4	105897896	3e-46	1.18	[1.16-1.21]	NPNT	30804561	Sakornsakolpat P	Nat Genet	35,735 cases, 222,076 controls	GCST007692
rs12697352	hypothyroidism	5	35837132	1e-08	NA		SPEF2 - IL7R	30595370	Kichaev G	Am J Hum Genet	approximately 459,000 European ancestry individuals	GCST007073
rs11178649	respiratory system disease	12	71139458	3e-09	NA		TSPAN8	30595370	Kichaev G	Am J Hum Genet	approximately 459,000 European ancestry individuals	GCST007076
rs1837253	respiratory system disease	5	111066174	2e-39	NA		BCLAF1P1 - TSLP	30595370	Kichaev G	Am J Hum Genet	approximately 459,000 European ancestry individuals	GCST007076
rs34712979	forced expiratory volume	4	105897896	9e-97	0.0567	[0.051-0.062] unit decrease	NPNT	30804560	Shrine N	Nat Genet	321,047 European ancestry individuals	GCST007432
rs34712979	FEV/FVC ratio	4	105897896	4e-134	0.0682	[0.063-0.074] unit decrease	NPNT	30804560	Shrine N	Nat Genet	321,047 European ancestry individuals	GCST007431
rs34712979	peak expiratory flow	4	105897896	2e-51	0.0433	[0.038-0.049] unit decrease	NPNT	30804560	Shrine N	Nat Genet	321,047 European ancestry individuals	GCST007430
rs34712979	FEV/FVC ratio	4	105897896	4e-181	NA		NPNT	30595370	Kichaev G	Am J Hum Genet	approximately 370,000 European ancestry individuals	GCST007080
rs659398	FEV/FVC ratio	8	102119072	6e-26	NA		NCALD	30595370	Kichaev G	Am J Hum Genet	approximately 370,000 European ancestry individuals	GCST007080
rs34290285	FEV/FVC ratio	2	241759225	6e-09	NA		D2HGDH	30595370	Kichaev G	Am J Hum Genet	approximately 370,000 European ancestry individuals	GCST007080
rs17293632	asthma	15	67150258	3e-70	NA		SMAD3	32296059	Han Y	Nat Commun	84,492 European ancestry cases, 2,149 African American cases, 606 Hispanic cases, 1,239 Japanese ancestry cases, 437,036 European ancestry controls, 6,055 African American controls, 792 Hispanic controls, 3,976 Japanese ancestry controls	GCST010043
rs12935657	asthma	16	11125184	8e-52	NA		CLEC16A	32296059	Han Y	Nat Commun	84,492 European ancestry cases, 2,149 African American cases, 606 Hispanic cases, 1,239 Japanese ancestry cases, 437,036 European ancestry controls, 6,055 African American controls, 792 Hispanic controls, 3,976 Japanese ancestry controls	GCST010043
rs6687430	asthma	1	10573188	8e-13	NA		PEX14	32296059	Han Y	Nat Commun	84,492 European ancestry cases, 2,149 African American cases, 606 Hispanic cases, 1,239 Japanese ancestry cases, 437,036 European ancestry controls, 6,055 African American controls, 792 Hispanic controls, 3,976 Japanese ancestry controls	GCST010043
rs2070901	asthma	1	161215268	7e-16	NA		FCER1G	32296059	Han Y	Nat Commun	84,492 European ancestry cases, 2,149 African American cases, 606 Hispanic cases, 1,239 Japanese ancestry cases, 437,036 European ancestry controls, 6,055 African American controls, 792 Hispanic controls, 3,976 Japanese ancestry controls	GCST010043
rs34290285	asthma	2	241759225	2e-55	NA		D2HGDH	32296059	Han Y	Nat Commun	84,492 European ancestry cases, 2,149 African American cases, 606 Hispanic cases, 1,239 Japanese ancestry cases, 437,036 European ancestry controls, 6,055 African American controls, 792 Hispanic controls, 3,976 Japanese ancestry controls	GCST010043
rs5743618	asthma	4	38797027	4e-42	NA		TLR1	32296059	Han Y	Nat Commun	84,492 European ancestry cases, 2,149 African American cases, 606 Hispanic cases, 1,239 Japanese ancestry cases, 437,036 European ancestry controls, 6,055 African American controls, 792 Hispanic controls, 3,976 Japanese ancestry controls	GCST010043
rs12697352	asthma	5	35837132	6e-21	NA		SPEF2 - IL7R	32296059	Han Y	Nat Commun	84,492 European ancestry cases, 2,149 African American cases, 606 Hispanic cases, 1,239 Japanese ancestry cases, 437,036 European ancestry controls, 6,055 African American controls, 792 Hispanic controls, 3,976 Japanese ancestry controls	GCST010043
rs1837253	asthma	5	111066174	8e-81	NA		BCLAF1P1 - TSLP	32296059	Han Y	Nat Commun	84,492 European ancestry cases, 2,149 African American cases, 606 Hispanic cases, 1,239 Japanese ancestry cases, 437,036 European ancestry controls, 6,055 African American controls, 792 Hispanic controls, 3,976 Japanese ancestry controls	GCST010043
rs992969	asthma	9	6209697	8e-107	NA		GTF3AP1 - IL33	32296059	Han Y	Nat Commun	84,492 European ancestry cases, 2,149 African American cases, 606 Hispanic cases, 1,239 Japanese ancestry cases, 437,036 European ancestry controls, 6,055 African American controls, 792 Hispanic controls, 3,976 Japanese ancestry controls	GCST010043
rs6687430	asthma	1	10573188	7e-11	1.0400028	[1.02780584230096-1.0523444593877]	PEX14	32296059	Han Y	Nat Commun	64,538 European ancestry cases, 239,321 European ancestry controls	GCST010042
rs2070901	asthma	1	161215268	4e-12	1.0477369	[1.03405413981002-1.06160062161201]	FCER1G	32296059	Han Y	Nat Commun	64,538 European ancestry cases, 239,321 European ancestry controls	GCST010042
rs76181804	asthma	1	198632575	3e-13	1.0707214	[1.05129066887765-1.09051130836444]	ATP6V1G3 - PTPRC	32296059	Han Y	Nat Commun	64,538 European ancestry cases, 239,321 European ancestry controls	GCST010042
rs992969	asthma	9	6209697	2e-78	1.1382953	[1.12298746975675-1.15381185720836]	GTF3AP1 - IL33	32296059	Han Y	Nat Commun	64,538 European ancestry cases, 239,321 European ancestry controls	GCST010042
rs34290285	asthma	2	241759225	2e-70	1.128748	[1.11375354565426-1.14394442412391]	D2HGDH	32296059	Han Y	Nat Commun	64,538 European ancestry cases, 239,321 European ancestry controls	GCST010042
rs5743618	asthma	4	38797027	7e-43	1.1047432	[1.0891439397501-1.12056588422624]	TLR1	32296059	Han Y	Nat Commun	64,538 European ancestry cases, 239,321 European ancestry controls	GCST010042
rs1837253	asthma	5	111066174	3e-57	1.114133	[1.09943653511993-1.12902587473291]	BCLAF1P1 - TSLP	32296059	Han Y	Nat Commun	64,538 European ancestry cases, 239,321 European ancestry controls	GCST010042
rs41285280	asthma	6	127970504	2e-17	1.0621314	[1.0474825755761-1.07698506650107]	PTPRK	32296059	Han Y	Nat Commun	64,538 European ancestry cases, 239,321 European ancestry controls	GCST010042
rs11178649	asthma	12	71139458	2e-09	1.037402	[1.02499484869509-1.04995944088449]	TSPAN8	32296059	Han Y	Nat Commun	64,538 European ancestry cases, 239,321 European ancestry controls	GCST010042
rs4807440	neutrophil count	19	1026478	4e-26	0.022406	[0.018-0.027] SD unit increase	RNU6-2 - CNN2	32888493	Chen MH	Cell	519,288 European ancestry individuals	GCST90002351
rs4807440	monocyte count	19	1026478	7e-34	NA		RNU6-2 - CNN2	32888493	Chen MH	Cell	639,696 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals	GCST90002344
rs4807440	lymphocyte count	19	1026478	2e-09	0.014238496	[0.0096-0.0189] unit increase	RNU6-2 - CNN2	32888494	Vuckovic D	Cell	408,112 British individuals	GCST90002388
rs1837253	Nasal Cavity Polyp	5	111066174	4e-29	1.3513513	[1.28-1.43]	BCLAF1P1 - TSLP	30643255	Kristjansson RP	Nat Genet	86 European ancestry whole-genome sequenced cases, 4,280 European ancestry cases, 13,941 European ancestry whole-genome sequenced controls, 700,740 European ancestry controls	GCST007443
rs4807440	monocyte count	19	1026478	4e-34	0.02509	[0.021-0.029] SD unit increase	RNU6-2 - CNN2	32888493	Chen MH	Cell	521,594 European ancestry individuals	GCST90002340
rs12697352	autoimmune thyroid disease	5	35837132	4e-11	1.0638298	[NR]	SPEF2 - IL7R	32581359	Saevarsdottir S	Nature	30,234 European ancestry cases, 724,172 European ancestry controls	GCST010571
rs166840	systolic blood pressure	17	19896385	2e-09	NA		ULK2 - AKAP10	30595370	Kichaev G	Am J Hum Genet	approximately 422,000 European ancestry individuals	GCST007087
rs11812460	platelet count	10	93072371	3e-11	0.026439	[0.019-0.034] SD units increase	CYP26C1 - CYP26A1	32888493	Chen MH	Cell	145,648 East Asian ancestry individuals	GCST90002358
rs34290285	adult onset asthma	2	241759225	8e-20	NA		D2HGDH	31669095	Zhu Z	J Allergy Clin Immunol	33,418 European ancestry cases, 393,186 European ancestry controls	GCST009842
rs1837253	adult onset asthma	5	111066174	4e-19	NA		BCLAF1P1 - TSLP	31669095	Zhu Z	J Allergy Clin Immunol	33,418 European ancestry cases, 393,186 European ancestry controls	GCST009842
rs4807440	myeloid white cell count	19	1026478	3e-35	NA		RNU6-2 - CNN2	32888493	Chen MH	Cell	746,667 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals	GCST90002378
rs4807440	myeloid white cell count	19	1026478	6e-35	0.025256	[0.021-0.029] SD unit increase	RNU6-2 - CNN2	32888493	Chen MH	Cell	562,243 European ancestry individuals	GCST90002374
rs4807440	mean platelet volume	19	1026478	5e-10	0.015555377	[0.011-0.02] unit increase	RNU6-2 - CNN2	32888494	Vuckovic D	Cell	408,112 British individuals	GCST90002395
rs4807440	monocyte count	19	1026478	8e-28	0.02544234	[0.021-0.03] unit increase	RNU6-2 - CNN2	32888494	Vuckovic D	Cell	408,112 British individuals	GCST90002393
rs6679677	neutrophil count	1	113761186	3e-25	0.037880443	[0.031-0.045] unit decrease	PHTF1 - RSBN1	32888494	Vuckovic D	Cell	408,112 British individuals	GCST90002398
rs1837253	asthma	5	111066174	4e-14	1.1360734	[1.099170099-1.174215642]	BCLAF1P1 - TSLP	32514122	Ishigaki K	Nat Genet	8,216 Japanese ancestry cases, 201,592 Japanese ancestry controls	GCST90013679
rs10797119	asthma	9	89587580	1e-08	1.1073811	[1.068996778-1.147143698]	SEMA4D - GADD45G	32514122	Ishigaki K	Nat Genet	8,216 Japanese ancestry cases, 201,592 Japanese ancestry controls	GCST90013679
rs12253380	asthma	10	8898431	3e-16	0.8736538	[0.845850941346268-0.902370609461935]	LINC02676	32514122	Ishigaki K	Nat Genet	8,216 Japanese ancestry cases, 201,592 Japanese ancestry controls	GCST90013679
rs1295686	atopic eczema	5	132660151	1e-09	0.8133829	[0.760806418-0.869592786]	TH2LCRR, IL13	32514122	Ishigaki K	Nat Genet	2,385 Japanese ancestry cases, 209,651 Japanese ancestry controls	GCST90013680
rs992969	adult onset asthma	9	6209697	8e-30	NA		GTF3AP1 - IL33	31669095	Zhu Z	J Allergy Clin Immunol	33,418 European ancestry cases, 393,186 European ancestry controls	GCST009842
rs34290285	allergic disease, age at onset	2	241759225	3e-13	0.036	[0.026-0.046] unit decrease	D2HGDH	32603359	Ferreira MAR	PLoS Genet	117,130 European ancestry individuals	GCST010985
rs34290285	allergic disease	2	241759225	3e-13	0.036	[0.026-0.046] unit decrease	D2HGDH	32603359	Ferreira MAR	PLoS Genet	477,968 European ancestry individuals	GCST010984
rs10995245	narcolepsy-cataplexy syndrome	10	62631615	1e-11	1.23	[1.16-1.31]	LINC02929	24204295	Han F	PLoS Genet	1,189 Chinese ancestry cases, 1,997 Chinese ancestry controls	GCST002260
rs1837253	asthma, seasonal allergic rhinitis	5	111066174	1e-09	1.17	[1.12-1.24]	BCLAF1P1 - TSLP	24388013	Ferreira MA	J Allergy Clin Immunol	6,685 European ancestry cases, 14,091 European ancestry controls	GCST002322
rs1295686	childhood onset asthma	5	132660151	2e-06	1.31	[1.17-1.48]	TH2LCRR, IL13	24241537	Bonnelykke K	Nat Genet	1,173 European ancestry cases, 2,511 European ancestry controls	GCST002275
rs1837253	asthma	5	111066174	1e-14	NA		BCLAF1P1 - TSLP	21804549	Torgerson DG	Nat Genet	2,088 European ancestry cases, 1,612 African American and African Caribbean cases, 1,688 Hispanic cases	GCST001182
rs3218255	tuberculosis	22	37148446	2e-07	4	[NR]	IL2RB	24057671	Chimusa ER	Hum Mol Genet	642 South African coloured cases, 91 South African coloured controls	GCST002198
rs4807440	leukocyte count	19	1026478	3e-10	0.02374496	[0.016-0.031] unit increase	RNU6-2 - CNN2	27863252	Astle WJ	Cell	172,435 European ancestry individuals	GCST004610
rs17293632	ankylosing spondylitis, psoriasis, ulcerative colitis, Crohn's disease, sclerosing cholangitis	15	67150258	1e-16	NA		SMAD3	26974007	Ellinghaus D	Nat Genet	8,726 European ancestry ankylosing spondylitis cases, 19,085 European ancestry Crohn’s disease cases, 6,530 European ancestry psoriasis cases, 3,408 European ancestry primary sclerosing cholangitis cases, 14,513 European ancestry ulcerative colitis cases, 34,213 European ancestry controls	GCST005537
rs6679677	rheumatoid arthritis, celiac disease	1	113761186	1e-53	1.41		PHTF1 - RSBN1	26546613	Gutierrez-Achury J	Hum Mol Genet	371 South Asian ancestry celiac disease cases, 3,138 European ancestry celiac disease cases,  4,418 European ancestry rheumatoid arthritis cases,  509 South Asian ancestry celiac disease controls, 2,473 European ancestry celiac disease controls, 3,300 European ancestry rheumatoid arthritis controls, 8,872 celiac disease cases, 9,401 rheumatoid arthritis cases, 4,845 celiac disease controls, 9,627 rheumatoid arthritis controls	GCST008644
rs1837253	eosinophil percentage of leukocytes	5	111066174	4e-21	0.03824089	[0.03-0.046] unit increase	BCLAF1P1 - TSLP	27863252	Astle WJ	Cell	172,378 European ancestry individuals	GCST004600
rs34290285	eosinophil percentage of leukocytes	2	241759225	2e-25	0.04248529	[0.035-0.05] unit decrease	D2HGDH	27863252	Astle WJ	Cell	172,378 European ancestry individuals	GCST004600
rs1295686	atopic eczema	5	132660151	2e-17	1.383	[1.283-1.49]	TH2LCRR, IL13	23886662	Weidinger S	Hum Mol Genet	1563 European ancestry cases, 4,054 European ancestry controls	GCST002100
rs1295686	atopic eczema	5	132660151	5e-09	1.347	[1.28-1.418]	TH2LCRR, IL13	25574825	Baurecht H	Am J Hum Genet	2,079 European ancestry cases, 3,867 European ancestry controls	GCST002737
rs1837253	asthma	5	111066174	3e-31	1.1415524	[1.12-1.17]	BCLAF1P1 - TSLP	27182965	Pickrell JK	Nat Genet	28,399 European ancestry cases, 128,843 European ancestry controls	GCST003987
rs34290285	asthma	2	241759225	2e-15	1.107	[1.079-1.135]	D2HGDH	27182965	Pickrell JK	Nat Genet	28,399 European ancestry cases, 128,843 European ancestry controls	GCST003987
rs5743618	asthma	4	38797027	4e-11	1.082	[1.057-1.107]	TLR1	27182965	Pickrell JK	Nat Genet	28,399 European ancestry cases, 128,843 European ancestry controls	GCST003987
rs34290285	eosinophil percentage of granulocytes	2	241759225	3e-21	0.03871675	[0.031-0.047] unit decrease	D2HGDH	27863252	Astle WJ	Cell	170,536 European ancestry individuals	GCST004617
rs1837253	eosinophil percentage of granulocytes	5	111066174	2e-18	0.0356266	[0.028-0.044] unit increase	BCLAF1P1 - TSLP	27863252	Astle WJ	Cell	170,536 European ancestry individuals	GCST004617
rs1775550	allergic disease	10	9010779	6e-11	1.067	[1.047-1.088]	LINC02676 - LINC00709	27182965	Pickrell JK	Nat Genet	66,973 European ancestry cases, 113,768 European ancestry controls	GCST003990
rs1295686	allergic disease	5	132660151	6e-10	1.061	[1.041-1.080]	TH2LCRR, IL13	27182965	Pickrell JK	Nat Genet	66,973 European ancestry cases, 113,768 European ancestry controls	GCST003990
rs6679677	anti-neutrophil antibody associated vasculitis	1	113761186	2e-08	1.4	1.25-1.57	PHTF1 - RSBN1	28029757	Merkel PA	Arthritis Rheumatol	1,015 European ancestry granulomatosis with polyangiitis cases, 206 European ancestry microscopic polyangiitis cases, 3,258 European ancestry controls.	GCST003976
rs1837253	neutrophil percentage of granulocytes	5	111066174	3e-15	0.03221306	[0.024-0.04] unit decrease	BCLAF1P1 - TSLP	27863252	Astle WJ	Cell	170,672 European ancestry individuals	GCST004623
rs4807440	monocyte count	19	1026478	3e-11	0.02493669	[0.018-0.032] unit increase	RNU6-2 - CNN2	27863252	Astle WJ	Cell	170,721 European ancestry individuals	GCST004625
rs34290285	neutrophil percentage of granulocytes	2	241759225	3e-18	0.03562407	[0.028-0.044] unit increase	D2HGDH	27863252	Astle WJ	Cell	170,672 European ancestry individuals	GCST004623
rs346835	basophil count, eosinophil count	2	8298563	7e-18	0.0326125	[0.025-0.04] unit decrease	LINC00299	27863252	Astle WJ	Cell	171,771 European ancestry individuals	GCST004624
rs34290285	basophil count, eosinophil count	2	241759225	5e-21	0.03838906	[0.03-0.046] unit decrease	D2HGDH	27863252	Astle WJ	Cell	171,771 European ancestry individuals	GCST004624
rs1837253	eosinophil count	5	111066174	2e-22	0.03960412	[0.032-0.048] unit increase	BCLAF1P1 - TSLP	27863252	Astle WJ	Cell	172,275 European ancestry individuals	GCST004606
rs34290285	eosinophil count	2	241759225	5e-24	0.04123634	[0.033-0.049] unit decrease	D2HGDH	27863252	Astle WJ	Cell	172,275 European ancestry individuals	GCST004606
rs34712979	forced expiratory volume	4	105897896	2e-21	0.072	[0.056-0.088] unit decrease	NPNT	28166213	Wain LV	Nat Genet	48,943 European ancestry individuals.	GCST004183
rs34712979	vital capacity	4	105897896	8e-09	0.044	[0.028-0.06] unit decrease	NPNT	28166213	Wain LV	Nat Genet	48,943 European ancestry individuals.	GCST004184
rs34712979	FEV/FVC ratio	4	105897896	2e-31	0.087	[0.073-0.101] unit decrease	NPNT	28166213	Wain LV	Nat Genet	48,943 European ancestry individuals	GCST004185
rs12935657	asthma, age at onset	16	11125184	2e-07	1.062	[1.04-1.08]	CLEC16A	30929738	Ferreira MAR	Am J Hum Genet	13,962 European ancestry childhood onset cases, 14,873 European ancestry adult onset cases	GCST007797
rs34290285	asthma, age at onset	2	241759225	2e-08	1.071	[1.05-1.09]	D2HGDH	30929738	Ferreira MAR	Am J Hum Genet	13,962 European ancestry childhood onset cases, 14,873 European ancestry adult onset cases	GCST007797
rs2070901	asthma, age at onset	1	161215268	1e-06	1.054	[1.03-1.08]	FCER1G	30929738	Ferreira MAR	Am J Hum Genet	13,962 European ancestry childhood onset cases, 14,873 European ancestry adult onset cases	GCST007797
rs12935657	asthma	16	11125184	7e-34	1.1	[1.08-1.12]	CLEC16A	30929738	Ferreira MAR	Am J Hum Genet	40,544 European ancestry cases, 300,671 European ancestry controls	GCST007798
rs1837253	asthma, age at onset	5	111066174	5e-15	1.095	[1.07-1.12]	BCLAF1P1 - TSLP	30929738	Ferreira MAR	Am J Hum Genet	13,962 European ancestry childhood onset cases, 14,873 European ancestry adult onset cases	GCST007797
rs992969	asthma, age at onset	9	6209697	1e-20	1.112	[1.09-1.13]	GTF3AP1 - IL33	30929738	Ferreira MAR	Am J Hum Genet	13,962 European ancestry childhood onset cases, 14,873 European ancestry adult onset cases	GCST007797
rs5743618	asthma, age at onset	4	38797027	3e-21	1.114	[1.09-1.14]	TLR1	30929738	Ferreira MAR	Am J Hum Genet	13,962 European ancestry childhood onset cases, 14,873 European ancestry adult onset cases	GCST007797
rs10995245	asthma	10	62631615	1e-08	1.042	[1.03-1.06]	LINC02929	30929738	Ferreira MAR	Am J Hum Genet	40,544 European ancestry cases, 300,671 European ancestry controls	GCST007798
rs1784775	asthma	11	111601736	2e-09	1.046	[1.03-1.06]	LAYN - SIK2	30929738	Ferreira MAR	Am J Hum Genet	40,544 European ancestry cases, 300,671 European ancestry controls	GCST007798
rs34290285	asthma	2	241759225	9e-52	1.124	[1.11-1.14]	D2HGDH	30929738	Ferreira MAR	Am J Hum Genet	40,544 European ancestry cases, 300,671 European ancestry controls	GCST007798
rs5743618	asthma	4	38797027	2e-31	1.097	[1.08-1.11]	TLR1	30929738	Ferreira MAR	Am J Hum Genet	40,544 European ancestry cases, 300,671 European ancestry controls	GCST007798
rs1837253	asthma	5	111066174	1e-41	1.11	[1.09-1.13]	BCLAF1P1 - TSLP	30929738	Ferreira MAR	Am J Hum Genet	40,544 European ancestry cases, 300,671 European ancestry controls	GCST007798
rs992969	asthma	9	6209697	3e-72	1.151	[1.14-1.17]	GTF3AP1 - IL33	30929738	Ferreira MAR	Am J Hum Genet	40,544 European ancestry cases, 300,671 European ancestry controls	GCST007798
rs10995245	childhood onset asthma	10	62631615	4e-10	1.048	[1.03-1.06]	LINC02929	30929738	Ferreira MAR	Am J Hum Genet	13,962 European ancestry cases, 300,671 European ancestry controls	GCST007800
rs2070901	childhood onset asthma	1	161215268	3e-32	1.1	[1.08-1.12]	FCER1G	30929738	Ferreira MAR	Am J Hum Genet	13,962 European ancestry cases, 300,671 European ancestry controls	GCST007800
rs12935657	childhood onset asthma	16	11125184	1e-49	1.133	[1.12-1.15]	CLEC16A	30929738	Ferreira MAR	Am J Hum Genet	13,962 European ancestry cases, 300,671 European ancestry controls	GCST007800
rs5743618	childhood onset asthma	4	38797027	3e-74	1.165	[1.15-1.18]	TLR1	30929738	Ferreira MAR	Am J Hum Genet	13,962 European ancestry cases, 300,671 European ancestry controls	GCST007800
rs34290285	childhood onset asthma	2	241759225	4e-69	1.168	[1.15-1.19]	D2HGDH	30929738	Ferreira MAR	Am J Hum Genet	13,962 European ancestry cases, 300,671 European ancestry controls	GCST007800
rs1837253	childhood onset asthma	5	111066174	7e-94	1.186	[1.17-1.2]	BCLAF1P1 - TSLP	30929738	Ferreira MAR	Am J Hum Genet	13,962 European ancestry cases, 300,671 European ancestry controls	GCST007800
rs1784775	adult onset asthma	11	111601736	6e-09	1.044	[1.03-1.06]	LAYN - SIK2	30929738	Ferreira MAR	Am J Hum Genet	26,582 European ancestry cases, 300,671 European ancestry controls	GCST007799
rs34290285	adult onset asthma	2	241759225	2e-28	1.097	[1.08-1.11]	D2HGDH	30929738	Ferreira MAR	Am J Hum Genet	26,582 European ancestry cases, 300,671 European ancestry controls	GCST007799
rs1837253	adult onset asthma	5	111066174	1e-18	1.074	[1.06-1.09]	BCLAF1P1 - TSLP	30929738	Ferreira MAR	Am J Hum Genet	26,582 European ancestry cases, 300,671 European ancestry controls	GCST007799
rs992969	adult onset asthma	9	6209697	2e-29	1.095	[1.08-1.11]	GTF3AP1 - IL33	30929738	Ferreira MAR	Am J Hum Genet	26,582 European ancestry cases, 300,671 European ancestry controls	GCST007799
rs2070901	asthma	1	161215268	9e-12	1.054	[1.04-1.07]	FCER1G	30929738	Ferreira MAR	Am J Hum Genet	40,544 European ancestry cases, 300,671 European ancestry controls	GCST007798
rs4807440	leukocyte count	19	1026478	2e-29	0.0262263	[0.022-0.031] unit increase	RNU6-2 - CNN2	32888494	Vuckovic D	Cell	408,112 British individuals	GCST90002407
rs34290285	asthma	2	241759225	2e-07	0.8129	[0.73-0.89]	D2HGDH	35368043	Chang D	Sci Rep	3,181 European ancestry cases, 3,590 European ancestry controls	GCST90105078
rs11154801	systemic lupus erythematosus	6	135418217	4e-07	1.11	[1.06-1.16]	AHI1	28714469	Langefeld CD	Nat Commun	6,748 European ancestry cases, 11,516 European ancestry controls, 2,970 African American cases, 2,452 African American controls, 1,872 Hispanic cases, 2,016 Hispanic controls	GCST005752
rs6679677	systemic lupus erythematosus	1	113761186	2e-23	1.41	[1.32-1.51]	PHTF1 - RSBN1	28714469	Langefeld CD	Nat Commun	6,748 European ancestry cases, 11,516 European ancestry controls	GCST007400
rs6679677	Immunosuppressant use measurement	1	113761186	3e-19	0.33426782	[0.26-0.41] unit increase	PHTF1 - RSBN1	31015401	Wu Y	Nat Commun	3,954 European ancestry cases, 268,648 European ancestry controls	GCST007933
rs12697352	Thyroid preparation use measurement	5	35837132	3e-10	0.060907226	[0.042-0.08] unit decrease	SPEF2 - IL7R	31015401	Wu Y	Nat Commun	24,832 European ancestry cases, 280,750 European ancestry controls	GCST007932
rs34290285	Glucocorticoid use measurement	2	241759225	2e-23	0.12759554	[0.1-0.15] unit decrease	D2HGDH	31015401	Wu Y	Nat Commun	17,352 European ancestry cases, 188,348 European ancestry controls	GCST007942
rs34290285	Antihistamine use measurement	2	241759225	6e-09	0.083370775	[0.055-0.112] unit decrease	D2HGDH	31015401	Wu Y	Nat Commun	13,984 European ancestry cases, 137,652 European ancestry controls	GCST007943
rs992969	Glucocorticoid use measurement	9	6209697	2e-27	0.13987124	[0.11-0.17] unit increase	GTF3AP1 - IL33	31015401	Wu Y	Nat Commun	17,352 European ancestry cases, 188,348 European ancestry controls	GCST007942
rs992969	Inhalant adrenergic use measurement	9	6209697	4e-39	0.1357923	[0.12-0.16] unit increase	GTF3AP1 - IL33	31015401	Wu Y	Nat Commun	28,880 European ancestry cases, 147,565 European ancestry controls	GCST007941
rs1837253	Inhalant adrenergic use measurement	5	111066174	4e-23	0.1019233	[0.082-0.122] unit decrease	BCLAF1P1 - TSLP	31015401	Wu Y	Nat Commun	28,880 European ancestry cases, 147,565 European ancestry controls	GCST007941
rs34290285	Inhalant adrenergic use measurement	2	241759225	5e-28	0.113481805	[0.093-0.134] unit decrease	D2HGDH	31015401	Wu Y	Nat Commun	28,880 European ancestry cases, 147,565 European ancestry controls	GCST007941
rs34290285	childhood onset asthma	2	241759225	2e-20	1.177	[1.137-1.219]	D2HGDH	31036433	Pividori M	Lancet Respir Med	9,433 British ancestry cases, 318,237 British ancestry controls	GCST007995
rs5743618	childhood onset asthma	4	38797027	3e-32	1.249	[1.203-1.295]	TLR1	31036433	Pividori M	Lancet Respir Med	9,433 British ancestry cases, 318,237 British ancestry controls	GCST007995
rs1837253	childhood onset asthma	5	111066174	2e-27	1.211	[1.169-1.253]	BCLAF1P1 - TSLP	31036433	Pividori M	Lancet Respir Med	9,433 British ancestry cases, 318,237 British ancestry controls	GCST007995
rs992969	adult onset asthma	9	6209697	3e-17	1.1	[1.076-1.125]	GTF3AP1 - IL33	31036433	Pividori M	Lancet Respir Med	21,564 British ancestry cases, 318,237 British ancestry controls	GCST007993
rs1837253	adult onset asthma	5	111066174	3e-13	1.088	[1.064-1.113]	BCLAF1P1 - TSLP	31036433	Pividori M	Lancet Respir Med	21,564 British ancestry cases, 318,237 British ancestry controls	GCST007993
rs34290285	adult onset asthma	2	241759225	2e-11	1.081	[1.056-1.106]	D2HGDH	31036433	Pividori M	Lancet Respir Med	21,564 British ancestry cases, 318,237 British ancestry controls	GCST007993
rs1837253	asthma	5	111066174	4e-06	0.733	[0.42-1.04] unit decrease	BCLAF1P1 - TSLP	31036433	Pividori M	Lancet Respir Med	37,846 British ancestry individuals	GCST007994
rs5743618	asthma	4	38797027	5e-22	1.578	[1.26-1.9] unit decrease	TLR1	31036433	Pividori M	Lancet Respir Med	37,846 British ancestry individuals	GCST007994
rs992969	childhood onset asthma	9	6209697	7e-42	1.248	[1.209-1.289]	GTF3AP1 - IL33	31036433	Pividori M	Lancet Respir Med	9,433 British ancestry cases, 318,237 British ancestry controls	GCST007995
rs6679677	rheumatoid arthritis	1	113761186	6e-25	1.98	[1.72-2.27]	PHTF1 - RSBN1	17554300	Wellcome Trust Case Control Consortium	Nature	1,860 European ancestry cases, 2,938 European ancestry controls	GCST000040
rs6679677	type 1 diabetes mellitus	1	113761186	5e-26	1.82	[1.59-2.09]	PHTF1 - RSBN1	17554300	Wellcome Trust Case Control Consortium	Nature	1,963 European ancestry cases, 2,938 European ancestry controls	GCST000043
rs6679677	type 1 diabetes mellitus	1	113761186	1e-40	NA		PHTF1 - RSBN1	18978792	Cooper JD	Nat Genet	3,561 European ancestry cases, 4,646 European ancestry controls	GCST000258
rs17293632	Crohn's disease	15	67150258	3e-19	1.12	[1.07-1.16]	SMAD3	21102463	Franke A	Nat Genet	6,333 European ancestry cases, 15,056 European ancestry controls	GCST000879
rs6679677	type 1 diabetes mellitus	1	113761186	8e-24	1.89	[1.67-2.13]	PHTF1 - RSBN1	17554260	Todd JA	Nat Genet	2,000 European ancestry cases, 3,000 European ancestry controls	GCST000038
rs11154801	multiple sclerosis	6	135418217	1e-13	1.13	[1.11-1.15]	AHI1	21833088	Sawcer S	Nature	9,772 European ancestry cases, 16,849 European ancestry controls	GCST001198
rs1295686	atopic eczema	5	132660151	2e-06	1.22	[NR]	TH2LCRR, IL13	23042114	Hirota T	Nat Genet	1,472 Japanese ancestry cases, 7,971 Japanese ancestry controls	GCST001709
rs1295686	asthma	5	132660151	1e-07	1.15	[1.09-1.20]	TH2LCRR, IL13	20860503	Moffatt MF	N Engl J Med	10,365 cases, 16,110 controls	GCST000804
rs6679677	rheumatoid arthritis	1	113761186	6e-42	1.79	[1.65-1.94]	PHTF1 - RSBN1	18794853	Raychaudhuri S	Nat Genet	3,393 European ancestry cases, 12,460 European ancestry controls	GCST000232
rs6679677	hypothyroidism	1	113761186	3e-13	1.361	[1.25-1.48]	PHTF1 - RSBN1	22493691	Eriksson N	PLoS One	3,736 European ancestry cases, 35,546 European ancestry controls	GCST001474
rs1837253	asthma	5	111066174	1e-16	1.17	[1.13-1.22]	BCLAF1P1 - TSLP	21804548	Hirota T	Nat Genet	1,532 Japanese ancestry cases, 3,304 Japanese ancestry controls	GCST001183
rs2070901	blood protein measurement	1	161215268	6e-09	0.173	[0.11-0.23] unit increase	FCER1G	32929287	Orru V	Nat Genet	3,112 Sardinian (founder/genetic isolate) ancestry individuals	GCST90001913
rs34712979	blood protein measurement	4	105897896	6e-50	0.316459	[0.27-0.36] unit decrease	NPNT	35078996	Gudjonsson A	Nat Commun	5,364 Icelandic ancestry individuals	GCST90089355
rs6679677	juvenile idiopathic arthritis	1	113761186	7e-30	1.49	[1.39-1.6]	PHTF1 - RSBN1	33106285	Lopez-Isac E	Ann Rheum Dis	3,305 European ancestry cases, 9,196 European ancestry controls	GCST90010715
rs17293632	hemorrhoid	15	67150258	7e-32	1.06	[1.05-1.07]	SMAD3	33888516	Zheng T	Gut	218,920 European ancestry cases, 725,213 European ancestry controls	GCST90014033
rs1837253	asthma	5	111066174	1e-44	1.10669	[1.09-1.12]	BCLAF1P1 - TSLP	31959851	Olafsdottir TA	Nat Commun	16,247 European ancestry cases, 346,486 European ancestry controls, 52,942 cases, 355,713 controls	GCST009798
rs34712979	asthma	4	105897896	4e-09	1.04312	[1.03-1.06]	NPNT	31959851	Olafsdottir TA	Nat Commun	16,247 European ancestry cases, 346,486 European ancestry controls, 52,942 cases, 355,713 controls	GCST009798
rs34290285	asthma	2	241759225	2e-23	1.1904762	[1.15-1.23]	D2HGDH	30552067	Shrine N	Lancet Respir Med	5,135 European ancestry cases, 25,675 European ancestry controls	GCST006911
rs703816	asthma	12	57103222	4e-13	1.12	[1.09-1.15]	STAT6	30552067	Shrine N	Lancet Respir Med	5,135 European ancestry cases, 25,675 European ancestry controls	GCST006911
rs1837253	asthma	5	111066174	2e-22	1.19	[1.15-1.23]	BCLAF1P1 - TSLP	30552067	Shrine N	Lancet Respir Med	5,135 European ancestry cases, 25,675 European ancestry controls	GCST006911
rs6679677	rheumatoid arthritis	1	113761186	1e-145	1.81	[1.73-1.89]	PHTF1 - RSBN1	33310728	Ha E	Ann Rheum Dis	14,361 European ancestry cases, 43,923 European ancestry controls, 8,267 East Asian ancestry cases, 244,741 East Asian ancestry controls	GCST90013534
rs6679677	Crohn's disease	1	113761186	2e-15	1.196	[1.129-1.268]	PHTF1 - RSBN1	23128233	Jostins L	Nature	Up to 12,924 European ancestry cases, up to 21,442 European ancestry controls	GCST001729
rs17293632	inflammatory bowel disease	15	67150258	6e-16	1.067	[1.032-1.102]	SMAD3	23128233	Jostins L	Nature	12,924 European ancestry cases, 21,442 European ancestry controls	GCST001725
rs17293632	ulcerative colitis	15	67150258	1e-07	1.0799718	[1.05-1.11]	SMAD3	26192919	Liu JZ	Nat Genet	6,968 European ancestry cases, 20,464 European ancestry controls	GCST003045
rs17293632	Crohn's disease	15	67150258	4e-20	1.1369898	[1.11-1.16]	SMAD3	26192919	Liu JZ	Nat Genet	5,956 European ancestry cases, 14,927 European ancestry controls	GCST003044
rs76181804	Crohn's disease	1	198632575	1e-10	NA		ATP6V1G3 - PTPRC	26192919	Liu JZ	Nat Genet	5,956 European ancestry cases, 14,927 European ancestry controls	GCST003044
rs17293632	inflammatory bowel disease	15	67150258	3e-20	1.1131175	[1.09-1.14]	SMAD3	26192919	Liu JZ	Nat Genet	12,882 European ancestry cases, 21,770 European ancestry controls	GCST003043
rs6679677	autoimmune thyroid disease, systemic lupus erythematosus, type 1 diabetes mellitus, ankylosing spondylitis, psoriasis, common variable immunodeficiency, celiac disease, ulcerative colitis, Crohn's disease, autoimmune disease, juvenile idiopathic arthritis	1	113761186	8e-11	NA		PHTF1 - RSBN1	26301688	Li YR	Nat Med	97 European ancestry thyroiditis cases, 107 European ancestry ankylosing spondylitis cases, 100 European ancestry psoriasis cases, 173 European ancestry celiac disease cases, 254 European ancestry systemic lupus erythematosus cases, 308 European ancestry common variable inmunodeficiency cases, 865 European ancestry ulcerative colitis cases, 1,086 European ancestry Type 1 diabetes cases, 1,123  European ancestry juvenile idiopathic arthritis cases, 1,922  European ancestry Crohn's disease cases, 10,718 European ancestry controls	GCST003097
rs12631337	peptic ulcer disease, Peptic ulcer and gastro-oesophageal reflux disease (GORD) drug use measurement, gastroesophageal reflux disease	3	50161104	2e-10	1.03		SEMA3F	33608531	Wu Y	Nat Commun	90,175 European ancestry cases, 366,152 European ancestry controls	GCST011500
rs5743618	immunoglobulin isotype switching measurement	4	38797027	4e-09	0.08	NR SD units decrease	TLR1	28628107	Jonsson S	Nat Genet	14,183 Icelandic ancestry individuals	GCST008574
rs61779328	body mass index	1	39487795	2e-07	0.018	[NR] unit decrease	MACF1 - BMP8A	30108127	Hoffmann TJ	Genetics	315,347 European ancestry individuals, 8,322 Hispanic/Latino individuals, 7,290 East Asian ancestry individuals, 3,069 African American individuals, 459 South Asian ancestry individuals	GCST006368
rs12697352	primary biliary cirrhosis	5	35837132	2e-09	1.4705882		SPEF2 - IL7R	30643196	Hitomi Y	Sci Rep	1,855 Japanese ancestry cases, 1,719 Japanese ancestry controls	GCST007036
rs6679677	monocyte count	1	113761186	4e-08	NA		PHTF1 - RSBN1	34469753	Kachuri L	Am J Hum Genet	234,690 European ancestry individuals	GCST90056177
rs4807440	monocyte count	19	1026478	7e-14	NA		RNU6-2 - CNN2	34469753	Kachuri L	Am J Hum Genet	234,690 European ancestry individuals	GCST90056177
rs6679677	non-melanoma skin carcinoma	1	113761186	3e-10	0.889667	[0.85-0.93]	PHTF1 - RSBN1	34290314	Brandes N	Sci Rep	18,944 White British ancestry cases, 255,886 White British ancestry controls	GCST90027058
rs11812460	low density lipoprotein cholesterol measurement	10	93072371	2e-15	0.0217	[0.016-0.027] unit decrease	CYP26C1 - CYP26A1	33462484	Sinnott-Armstrong N	Nat Genet	341,875 European ancestry individuals, 6,003 African ancestry individuals, 7,319 South Asian ancestry individuals	GCST90019512
rs11812460	IGF-1 measurement	10	93072371	1e-16	0.0226	[0.017-0.028] unit decrease	CYP26C1 - CYP26A1	33462484	Sinnott-Armstrong N	Nat Genet	340,567 European ancestry individuals, 5,974 African ancestry individuals, 7,283 South Asian ancestry individuals	GCST90019511
rs17293632	IGF-1 measurement	15	67150258	1e-12	0.02	[0.015-0.025] unit decrease	SMAD3	33462484	Sinnott-Armstrong N	Nat Genet	340,567 European ancestry individuals, 5,974 African ancestry individuals, 7,283 South Asian ancestry individuals	GCST90019511
rs34290285	eosinophil count	2	241759225	4e-37	NA		D2HGDH	34469753	Kachuri L	Am J Hum Genet	234,763 European ancestry individuals	GCST90056180
rs992969	asthma	9	6209697	5e-67	1.1319132	[1.11-1.15]	GTF3AP1 - IL33	31959851	Olafsdottir TA	Nat Commun	16,247 European ancestry cases, 346,486 European ancestry controls, 52,942 cases, 355,713 controls	GCST009798
rs34290285	asthma	2	241759225	5e-36	1.0953622	[1.08-1.11]	D2HGDH	31959851	Olafsdottir TA	Nat Commun	16,247 European ancestry cases, 346,486 European ancestry controls, 52,942 cases, 355,713 controls	GCST009798
rs5743618	asthma	4	38797027	4e-17	1.0640788	[1.05-1.08]	TLR1	31959851	Olafsdottir TA	Nat Commun	16,247 European ancestry cases, 346,486 European ancestry controls, 52,942 cases, 355,713 controls	GCST009798
rs34712979	smoking status measurement, chronic obstructive pulmonary disease	4	105897896	8e-43	NA	[NR]	NPNT	33106845	Kim W	Am J Epidemiol	21,077 European ancestry cases, 179,689 European ancestry controls	GCST90016585
rs34712979	chronic obstructive pulmonary disease	4	105897896	1e-29	1.23	[1.19-1.27]	NPNT	33106845	Kim W	Am J Epidemiol	8,631 European ancestry cases, 120,544 European ancestry controls	GCST90016589
rs34712979	chronic obstructive pulmonary disease	4	105897896	2e-16	1.15	[1.11-1.19]	NPNT	33106845	Kim W	Am J Epidemiol	12,446 European ancestry cases, 59,145 European ancestry controls	GCST90016588
rs34712979	chronic obstructive pulmonary disease	4	105897896	1e-29	1.23	[1.18-1.27]	NPNT	33106845	Kim W	Am J Epidemiol	21,077 European ancestry cases, 179,689 European ancestry controls	GCST90016586
rs34712979	chronic obstructive pulmonary disease	4	105897896	6e-39	1.19	[1.16-1.22]	NPNT	33106845	Kim W	Am J Epidemiol	16,488 European ancestry cases, 169,688 European ancestry controls	GCST90016594
rs34712979	smoking status measurement, chronic obstructive pulmonary disease	4	105897896	2e-41	NA	[NR]	NPNT	33106845	Kim W	Am J Epidemiol	21,077 European ancestry cases, 179,689 European ancestry controls	GCST90016590
rs34712979	chronic obstructive pulmonary disease	4	105897896	3e-39	1.19	[1.16-1.22]	NPNT	33106845	Kim W	Am J Epidemiol	21,077 European ancestry cases, 179,689 European ancestry controls	GCST90016591
rs166840	cortical thickness	17	19896385	3e-12	NA		ULK2 - AKAP10	34560273	Shadrin AA	Neuroimage	35,657 White British ancestry individuals	GCST90091061
rs6679677	lymphocyte count	1	113761186	7e-35	NA		PHTF1 - RSBN1	34469753	Kachuri L	Am J Hum Genet	234,778 European ancestry individuals	GCST90085815
rs6679677	platelet-to-lymphocyte ratio	1	113761186	5e-31	NA		PHTF1 - RSBN1	34469753	Kachuri L	Am J Hum Genet	234,552 European ancestry individuals	GCST90056184
rs6679677	neutrophil count	1	113761186	3e-16	NA		PHTF1 - RSBN1	34469753	Kachuri L	Am J Hum Genet	234,802 European ancestry individuals	GCST90056178
rs4807440	neutrophil count	19	1026478	1e-10	NA		RNU6-2 - CNN2	34469753	Kachuri L	Am J Hum Genet	234,802 European ancestry individuals	GCST90056178
rs6687430	asthma	1	10573188	3e-08	0.036332093	[0.024-0.049] unit increase	PEX14	34103634	Valette K	Commun Biol	56,167 White-British ancestry cases, 352,255 White-British ancestry controls	GCST90014325
rs5743618	asthma	4	38797027	3e-17	0.06644481	[0.051-0.082] unit decrease	TLR1	34103634	Valette K	Commun Biol	56,167 White-British ancestry cases, 352,255 White-British ancestry controls	GCST90014325
rs992969	asthma	9	6209697	1e-56	0.11990876	[0.11-0.13] unit decrease	GTF3AP1 - IL33	34103634	Valette K	Commun Biol	56,167 White-British ancestry cases, 352,255 White-British ancestry controls	GCST90014325
rs11178649	asthma	12	71139458	1e-10	0.04292547	[0.03-0.056] unit decrease	TSPAN8	34103634	Valette K	Commun Biol	56,167 White-British ancestry cases, 352,255 White-British ancestry controls	GCST90014325
rs34290285	asthma	2	241759225	1e-39	0.0988716	[0.084-0.114] unit decrease	D2HGDH	34103634	Valette K	Commun Biol	56,167 White-British ancestry cases, 352,255 White-British ancestry controls	GCST90014325
rs1837253	asthma	5	111066174	1e-47	0.10835559	[0.094-0.123] unit increase	BCLAF1P1 - TSLP	34103634	Valette K	Commun Biol	56,167 White-British ancestry cases, 352,255 White-British ancestry controls	GCST90014325
rs11812460	apolipoprotein B measurement	10	93072371	2e-17	0.0233	[0.018-0.029] unit decrease	CYP26C1 - CYP26A1	33462484	Sinnott-Armstrong N	Nat Genet	340,860 European ancestry individuals, 5,962 African ancestry individuals, 7,275 South Asian ancestry individuals	GCST90019496
rs11812460	total cholesterol measurement	10	93072371	2e-11	0.0182	[0.013-0.023] unit decrease	CYP26C1 - CYP26A1	33462484	Sinnott-Armstrong N	Nat Genet	342,508 European ancestry individuals, 6,014 African ancestry individuals, 7,336 South Asian ancestry individuals	GCST90019501
rs1702877	age at first birth measurement	12	56034024	8e-10	0.0602	[0.041-0.079] unit increase	IKZF4	34211149	Mills MC	Nat Hum Behav	542,901 European ancestry individuals	GCST90000050
rs11812460	bilirubin measurement	10	93072371	1e-14	0.0211	[0.016-0.026] unit increase	CYP26C1 - CYP26A1	33462484	Sinnott-Armstrong N	Nat Genet	341,077 European ancestry individuals, 5,978 African ancestry individuals, 7,313 South Asian ancestry individuals	GCST90019521
rs11812460	triglyceride measurement	10	93072371	3e-15	0.0216	[0.016-0.027] unit decrease	CYP26C1 - CYP26A1	33462484	Sinnott-Armstrong N	Nat Genet	342,233 European ancestry individuals, 6,014 African ancestry individuals, 7,330 South Asian ancestry individuals	GCST90019523
rs11812460	serum gamma-glutamyl transferase measurement	10	93072371	4e-11	0.018	[0.013-0.023] unit decrease	CYP26C1 - CYP26A1	33462484	Sinnott-Armstrong N	Nat Genet	342,339 European ancestry individuals, 6,015 African ancestry individuals, 7,336 South Asian ancestry individuals	GCST90019507
rs11812460	creatinine measurement	10	93072371	4e-11	0.018	[0.013-0.023] unit increase	CYP26C1 - CYP26A1	33462484	Sinnott-Armstrong N	Nat Genet	342,376 European ancestry individuals, 6,016 African ancestry individuals, 7,339 South Asian ancestry individuals	GCST90019502
rs11812460	bilirubin measurement	10	93072371	6e-13	0.0213	[0.015-0.027] unit increase	CYP26C1 - CYP26A1	33462484	Sinnott-Armstrong N	Nat Genet	291,512 European ancestry individuals, 5,007 African ancestry individuals, 6,088 South Asian ancestry individuals	GCST90019505
rs11812460	glomerular filtration rate	10	93072371	3e-10	0.0172	[0.012-0.022] unit decrease	CYP26C1 - CYP26A1	33462484	Sinnott-Armstrong N	Nat Genet	342,376 European ancestry individuals, 6,016 African ancestry individuals, 7,339 South Asian ancestry individuals	GCST90019506
rs1837253	asthma, chronic obstructive pulmonary disease	5	111066174	2e-18	1.162	[1.124-1.202]	BCLAF1P1 - TSLP	35104449	John C	Chest	8,068 European ancestry cases, 40,360 European ancestry controls	GCST90102597
rs34290285	asthma, chronic obstructive pulmonary disease	2	241759225	4e-11	0.89	[0.859-0.921]	D2HGDH	35104449	John C	Chest	8,068 European ancestry cases, 40,360 European ancestry controls	GCST90102597
rs6679677	rheumatoid arthritis, ulcerative colitis	1	113761186	5e-34	0.1	NR unit decrease	PHTF1 - RSBN1	33686288	Peyrot WJ	Nat Genet	6,968 ulcerative colitis cases, 8,875 rheumatoid arthritis cases	GCST90016625
rs7521458	C-reactive protein measurement	1	154435237	3e-11	0.1	[0.061-0.139] unit decrease	IL6R	37479695	Cheng S	Cell Discov	9,947 Han Chinese ancestry individuals, 294 individuals	GCST90319532
rs10995245	atopic eczema	10	62631615	5e-12	1.07	[1.05-1.1]	LINC02929	34116867	Tanaka N	J Allergy Clin Immunol	2,597 Japanese ancestry cases, 110,504 Japanese ancestry controls, 25,685 European ancestry cases, 76,768 European ancestry controls	GCST90086149
rs34290285	atopic eczema	2	241759225	2e-16	0.91	[0.89-0.93]	D2HGDH	34116867	Tanaka N	J Allergy Clin Immunol	2,597 Japanese ancestry cases, 110,504 Japanese ancestry controls, 25,685 European ancestry cases, 76,768 European ancestry controls	GCST90086149
rs17293632	asthma, endometriosis	15	67150258	7e-15	0.08	unit increase	SMAD3	35472084	Adewuyi EO	Hum Reprod	17,054 European, Japanese ancestry endometriosis cases, 19,554 European, Japanese ancestry asthma cases, 483,220 European, Japanese ancestry controls	GCST90102599
rs13098877	asthma, endometriosis	3	188415375	8e-08	0.042	unit decrease	LPP	35472084	Adewuyi EO	Hum Reprod	17,054 European, Japanese ancestry endometriosis cases, 26,332 European, Japanese ancestry asthma cases, 567,363 European, Japanese ancestry controls	GCST90102598
rs34290285	Eczematoid dermatitis	2	241759225	6e-09	0.93		D2HGDH	34785669	Grosche S	Nat Commun	20,016 European ancestry cases, 380,433 European ancestry controls	GCST90044763
rs1904522	Eczematoid dermatitis	4	122415763	3e-13	1.09		ADAD1	34785669	Grosche S	Nat Commun	20,016 European ancestry cases, 380,433 European ancestry controls	GCST90044763
rs34712979	chronic obstructive pulmonary disease	4	105897896	2e-22	1.18	[1.14-1.22]	NPNT	35308900	Joo J	AMIA Annu Symp Proc	11,311 British ancestry female cases, 123,714 British ancestry female controls	GCST90103985
rs34712979	chronic obstructive pulmonary disease	4	105897896	1e-25	1.18	[1.14-1.22]	NPNT	35308900	Joo J	AMIA Annu Symp Proc	12,958 British ancestry male cases, 95,631 British ancestry male controls	GCST90103984
rs6679677	alkaline phosphatase measurement	1	113761186	3e-15	0.0302	[0.023-0.038] unit decrease	PHTF1 - RSBN1	34594039	Sakaue S	Nat Genet	344,292 European ancestry individuals, 118,886 East Asian ancestry individuals	GCST90018942
rs10797119	triglyceride:HDL cholesterol ratio	9	89587580	3e-13	0.0231	[0.018-0.028] unit increase	SEMA4D - GADD45G	38200128	Oliveri A	Nat Genet	402,398 European ancestry individuals	GCST90295949
rs10797119	triglyceride:HDL cholesterol ratio	9	89587580	8e-11	0.0238	[0.018-0.03] unit increase	SEMA4D - GADD45G	38200128	Oliveri A	Nat Genet	216,649 European ancestry individuals	GCST90295951
rs3804594	asthma	3	122273978	5e-09	0.079734884	[0.053-0.106] unit increase	CASR	34594039	Sakaue S	Nat Genet	13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018575
rs13098877	asthma	3	188415375	3e-09	0.08360758	[0.056-0.111] unit decrease	LPP	34594039	Sakaue S	Nat Genet	13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018575
rs1837253	asthma	5	111066174	1e-17	0.121619895	[0.094-0.149] unit increase	BCLAF1P1 - TSLP	34594039	Sakaue S	Nat Genet	13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018575
rs1295686	asthma	5	132660151	3e-08	0.081391685	[0.053-0.11] unit decrease	TH2LCRR, IL13	34594039	Sakaue S	Nat Genet	13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018575
rs12253380	asthma	10	8898431	3e-22	0.13443829	[0.11-0.16] unit decrease	LINC02676	34594039	Sakaue S	Nat Genet	13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018575
rs1702877	asthma	12	56034024	1e-11	0.11719969	[0.083-0.151] unit increase	IKZF4	34594039	Sakaue S	Nat Genet	13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018575
rs12253380	eosinophil count	10	8898431	4e-13	0.0329333	[0.024-0.042] unit decrease	LINC02676	34594039	Sakaue S	Nat Genet	93,063 East Asian ancestry individuals	GCST90018733
rs1295686	serum IgE measurement	5	132660151	2e-13	NA		TH2LCRR, IL13	34536413	Daya M	J Allergy Clin Immunol	5,008 African American individuals, 12,908 European ancestry individuals, 3,985 Hispanic individuals	GCST90091054
rs1837253	Nasal Cavity Polyp	5	111066174	2e-32	0.2789	[0.23-0.32] unit increase	BCLAF1P1 - TSLP	34594039	Sakaue S	Nat Genet	5,093 European ancestry cases, 444,966 European ancestry controls, 160 East Asian ancestry cases, 151,846 East Asian ancestry controls	GCST90018883
rs34290285	childhood onset asthma	2	241759225	7e-23	0.105	[0.084-0.126] unit decrease	D2HGDH	34594039	Sakaue S	Nat Genet	27,712 European ancestry cases, 411,131 European ancestry controls, 547 East Asian ancestry cases, 161,803 East Asian ancestry controls	GCST90018895
rs5743618	childhood onset asthma	4	38797027	2e-10	0.0717	[0.05-0.094] unit decrease	TLR1	34594039	Sakaue S	Nat Genet	27,712 European ancestry cases, 411,131 European ancestry controls, 547 East Asian ancestry cases, 161,803 East Asian ancestry controls	GCST90018895
rs13263709	childhood onset asthma	8	80374940	3e-09	0.0571	[0.038-0.076] unit decrease	RPL13AP18 - RNU6-1213P	34594039	Sakaue S	Nat Genet	27,712 European ancestry cases, 411,131 European ancestry controls, 547 East Asian ancestry cases, 161,803 East Asian ancestry controls	GCST90018895
rs992969	childhood onset asthma	9	6209697	9e-28	0.1173	[0.096-0.138] unit decrease	GTF3AP1 - IL33	34594039	Sakaue S	Nat Genet	27,712 European ancestry cases, 411,131 European ancestry controls, 547 East Asian ancestry cases, 161,803 East Asian ancestry controls	GCST90018895
rs1702877	childhood onset asthma	12	56034024	6e-10	0.0602	[0.041-0.079] unit increase	IKZF4	34594039	Sakaue S	Nat Genet	27,712 European ancestry cases, 411,131 European ancestry controls, 547 East Asian ancestry cases, 161,803 East Asian ancestry controls	GCST90018895
rs72941069	asthma	11	65725735	4e-10	0.0662	[0.045-0.087] unit decrease	RNASEH2C - KRT8P26	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs1702877	asthma	12	56034024	3e-18	0.0663	[0.051-0.081] unit increase	IKZF4	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs703816	asthma	12	57103222	2e-15	0.0578	[0.043-0.072] unit increase	STAT6	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs11178649	asthma	12	71139458	4e-08	0.0391	[0.025-0.053] unit decrease	TSPAN8	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs12935657	asthma	16	11125184	3e-16	0.0722	[0.055-0.089] unit decrease	CLEC16A	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs3024556	asthma	16	27344041	1e-24	0.0764	[0.062-0.091] unit increase	IL4R	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs4641805	asthma	17	75768419	5e-08	0.0585	[0.038-0.079] unit increase	GALK1 - H3-3B	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs6687430	asthma	1	10573188	2e-09	0.0431	[0.029-0.057] unit increase	PEX14	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs12122629	asthma	1	152101640	6e-12	0.1381	[0.099-0.177] unit increase	TCHHL1 - TCHH	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs7521458	asthma	1	154435237	1e-08	0.0407	[0.027-0.055] unit increase	IL6R	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs13098877	asthma	3	188415375	1e-12	0.0499	[0.036-0.064] unit decrease	LPP	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs34712979	asthma	4	105897896	3e-10	0.0577	[0.04-0.076] unit increase	NPNT	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs1904522	asthma	4	122415763	2e-14	0.0546	[0.041-0.069] unit increase	ADAD1	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs5743618	asthma	4	38797027	3e-11	0.0664	[0.047-0.086] unit decrease	TLR1	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs1837253	asthma	5	111066174	7e-45	0.109	[0.094-0.124] unit increase	BCLAF1P1 - TSLP	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs13188700	asthma	5	142115574	1e-10	0.0459	[0.032-0.06] unit increase	NDFIP1	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs12697352	asthma	5	35837132	3e-14	0.0572	[0.043-0.072] unit decrease	SPEF2 - IL7R	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs12700215	asthma	7	20544936	1e-10	0.0477	[0.033-0.062] unit decrease	ITGB8 - EEF1A1P27	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs13263709	asthma	8	80374940	2e-13	0.053	[0.039-0.067] unit decrease	RPL13AP18 - RNU6-1213P	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs992969	asthma	9	6209697	2e-28	0.1001	[0.082-0.118] unit decrease	GTF3AP1 - IL33	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs10995245	asthma	10	62631615	1e-09	0.0435	[0.03-0.057] unit increase	LINC02929	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs1775550	asthma	10	9010779	8e-41	0.1142	[0.098-0.131] unit decrease	LINC02676 - LINC00709	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs61907683	asthma	11	128283912	5e-12	0.0582	[0.042-0.075] unit decrease	LINC02098 - ETS1	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs1837253	chronic rhinosinusitis	5	111066174	2e-08	0.0827	[0.054-0.112] unit increase	BCLAF1P1 - TSLP	34594039	Sakaue S	Nat Genet	7,529 European ancestry cases, 444,966 European ancestry controls, 4,617 East Asian ancestry cases, 152,226 East Asian ancestry controls	GCST90018823
rs2070901	asthma	1	161215268	4e-10	0.0469	[0.032-0.062] unit increase	FCER1G	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs34276574	asthma	1	167449231	3e-08	0.0489	[0.032-0.066] unit decrease	CD247	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs76181804	asthma	1	198632575	9e-10	0.0808	[0.055-0.107] unit decrease	ATP6V1G3 - PTPRC	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs3732192	asthma	2	228727588	6e-09	0.073	[0.048-0.098] unit decrease	LINC01807	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs34290285	asthma	2	241759225	6e-37	0.108	[0.091-0.125] unit decrease	D2HGDH	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs346835	asthma	2	8298563	5e-13	0.0537	[0.039-0.068] unit decrease	LINC00299	34594039	Sakaue S	Nat Genet	38,369 European ancestry cases, 411,131 European ancestry controls, 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls	GCST90018795
rs166840	glomerular filtration rate	17	19896385	3e-10	6.32	z score increase	ULK2 - AKAP10	35710981	Liu H	Nat Genet	1,205,871 European ancestry individuals, 168,300 East Asian ancestry individuals, 63,553 African ancestry individuals, 23,509 Hispanic or Latin American individuals, 22,103 African American individuals, 21,791 Central Asian or South Asian ancestry individuals, 1,502 Middle Eastern ancestry individuals, 939 other admixed ancestry individuals, 602 Native American ancestry individuals, 150 Asian ancestry individuals, 339 individuals	GCST90100220
rs34290285	eosinophil count	2	241759225	2e-60	0.0316	[0.028-0.035] unit decrease	D2HGDH	34594039	Sakaue S	Nat Genet	349,856 European ancestry individuals, 93,063 East Asian ancestry individuals	GCST90018953
rs992969	eosinophil count	9	6209697	2e-213	0.0624	[0.058-0.066] unit decrease	GTF3AP1 - IL33	34594039	Sakaue S	Nat Genet	349,856 European ancestry individuals, 93,063 East Asian ancestry individuals	GCST90018953
rs346835	eosinophil count	2	8298563	9e-27	0.0188	[0.015-0.022] unit decrease	LINC00299	34594039	Sakaue S	Nat Genet	349,856 European ancestry individuals, 93,063 East Asian ancestry individuals	GCST90018953
rs12697352	eosinophil count	5	35837132	8e-41	0.0236	[0.02-0.027] unit decrease	SPEF2 - IL7R	34594039	Sakaue S	Nat Genet	349,856 European ancestry individuals, 93,063 East Asian ancestry individuals	GCST90018953
rs13188700	mean corpuscular hemoglobin	5	142115574	2e-12	0.0143	[0.01-0.018] unit decrease	NDFIP1	34594039	Sakaue S	Nat Genet	350,472 European ancestry individuals, 128,028 East Asian ancestry individuals	GCST90018964
rs6679677	rheumatoid arthritis	1	113761186	4e-144	1.41		PHTF1 - RSBN1	35470158	Saevarsdottir S	Ann Rheum Dis	26,612 European ancestry cases, 869,454 European ancestry controls, 4,701 cases, 125,923 controls	GCST90131437
rs5743618	taste liking measurement	4	38797027	7e-10	0.0261	[0.018-0.034] unit decrease	TLR1	35585065	May-Wilson S	Nat Commun	155,376 European ancestry individuals	GCST90094861
rs6679677	rheumatoid arthritis, ACPA-positive rheumatoid arthritis, rheumatoid factor seropositivity measurement	1	113761186	4e-161	1.59		PHTF1 - RSBN1	35470158	Saevarsdottir S	Ann Rheum Dis	14,551 European ancestry cases, 846,260 European ancestry controls, 3,468 cases, 145,344 controls	GCST90131438
rs4641805	total blood protein measurement	17	75768419	2e-10	0.0199	[0.014-0.026] unit decrease	GALK1 - H3-3B	34594039	Sakaue S	Nat Genet	314,921 European ancestry individuals, 133,321 East Asian ancestry individuals	GCST90018976
rs4807440	monocyte count	19	1026478	3e-16	0.0175	[0.013-0.022] unit increase	RNU6-2 - CNN2	34594039	Sakaue S	Nat Genet	349,856 European ancestry individuals, 95,119 East Asian ancestry individuals	GCST90018967
rs5743618	Death in infancy	4	38797027	3e-19	NA		TLR1	35290122	Wu Y	Proc Natl Acad Sci U S A	330,340 European ancestry individuals	GCST90095047
rs992969	Inhalant adrenergic use measurement	9	6209697	6e-40	0.1351	[0.12-0.16] unit decrease	GTF3AP1 - IL33	34594039	Sakaue S	Nat Genet	28,880 European ancestry cases, 147,565 European ancestry controls, 5,880 East Asian ancestry cases, 172,846 East Asian ancestry controls	GCST90018999
rs703816	Inhalant adrenergic use measurement	12	57103222	1e-17	0.0734	[0.057-0.09] unit increase	STAT6	34594039	Sakaue S	Nat Genet	28,880 European ancestry cases, 147,565 European ancestry controls, 5,880 East Asian ancestry cases, 172,846 East Asian ancestry controls	GCST90018999
rs2671654	Inhalant adrenergic use measurement	17	49390649	4e-11	0.057	[0.04-0.074] unit decrease	ZNF652-AS1 - PHB1	34594039	Sakaue S	Nat Genet	28,880 European ancestry cases, 147,565 European ancestry controls, 5,880 East Asian ancestry cases, 172,846 East Asian ancestry controls	GCST90018999
rs34290285	Glucocorticoid use measurement	2	241759225	3e-26	0.1125	[0.092-0.133] unit decrease	D2HGDH	34594039	Sakaue S	Nat Genet	17,352 European ancestry cases, 188,348 European ancestry controls, 13,102 East Asian ancestry cases, 165,624 East Asian ancestry controls	GCST90019000
rs992969	Glucocorticoid use measurement	9	6209697	8e-27	0.131	[0.11-0.15] unit decrease	GTF3AP1 - IL33	34594039	Sakaue S	Nat Genet	17,352 European ancestry cases, 188,348 European ancestry controls, 13,102 East Asian ancestry cases, 165,624 East Asian ancestry controls	GCST90019000
rs34290285	Antihistamine use measurement	2	241759225	6e-11	0.0781	[0.055-0.101] unit decrease	D2HGDH	34594039	Sakaue S	Nat Genet	13,984 European ancestry cases, 137,652 European ancestry controls, 10,163 East Asian ancestry cases, 168,563 East Asian ancestry controls	GCST90019001
rs2070901	Inhalant adrenergic use measurement	1	161215268	3e-09	0.0531	[0.035-0.071] unit increase	FCER1G	34594039	Sakaue S	Nat Genet	28,880 European ancestry cases, 147,565 European ancestry controls, 5,880 East Asian ancestry cases, 172,846 East Asian ancestry controls	GCST90018999
rs34290285	Inhalant adrenergic use measurement	2	241759225	7e-33	0.1161	[0.097-0.135] unit decrease	D2HGDH	34594039	Sakaue S	Nat Genet	28,880 European ancestry cases, 147,565 European ancestry controls, 5,880 East Asian ancestry cases, 172,846 East Asian ancestry controls	GCST90018999
rs1837253	Inhalant adrenergic use measurement	5	111066174	1e-27	0.0996	[0.082-0.118] unit increase	BCLAF1P1 - TSLP	34594039	Sakaue S	Nat Genet	28,880 European ancestry cases, 147,565 European ancestry controls, 5,880 East Asian ancestry cases, 172,846 East Asian ancestry controls	GCST90018999
rs6679677	Immunosuppressant use measurement	1	113761186	3e-19	0.3343	[0.26-0.41] unit increase	PHTF1 - RSBN1	34594039	Sakaue S	Nat Genet	3,954 European ancestry cases, 268,648 European ancestry controls, 3,483 East Asian ancestry cases, 175,243 East Asian ancestry controls	GCST90018991
rs12697352	Thyroid preparation use measurement	5	35837132	7e-12	0.0634	[0.045-0.081] unit decrease	SPEF2 - IL7R	34594039	Sakaue S	Nat Genet	24,832 European ancestry cases, 280,750 European ancestry controls, 3,103 East Asian ancestry cases, 175,623 East Asian ancestry controls	GCST90018990
rs34290285	eosinophil count	2	241759225	6e-15	0.043	[0.033-0.053] unit decrease	D2HGDH	35935937	Hoglund J	Front Immunol	365,954 British ancestry individuals	GCST90134621
rs1837253	asthma	5	111066174	7e-36	0.8994247	[0.88-0.92]	BCLAF1P1 - TSLP	36344522	Jia G	Nat Commun	44,383 European ancestry cases, 260,715 European ancestry controls	GCST90244761
rs34290285	asthma	2	241759225	1e-33	0.90212697	[0.89-0.92]	D2HGDH	36344522	Jia G	Nat Commun	44,383 European ancestry cases, 260,715 European ancestry controls	GCST90244761
rs13263709	asthma	8	80374940	4e-18	1.0682267	[1.05-1.08]	RPL13AP18 - RNU6-1213P	36344522	Jia G	Nat Commun	44,383 European ancestry cases, 260,715 European ancestry controls	GCST90244761
rs2834787	asthma	21	35130261	7e-09	1.059715	[1.04-1.08]	RUNX1	36344522	Jia G	Nat Commun	44,383 European ancestry cases, 260,715 European ancestry controls	GCST90244761
rs34290285	asthma	2	241759225	6e-10	0.8895852	[0.85-0.93]	D2HGDH	36344522	Jia G	Nat Commun	44,383 European ancestry cases, 260,715 European ancestry controls	GCST90244762
rs992969	asthma	9	6209697	1e-16	1.1629966	[1.13-1.2]	GTF3AP1 - IL33	36344522	Jia G	Nat Commun	44,383 European ancestry cases, 260,715 European ancestry controls	GCST90244762
rs34290285	asthma	2	241759225	6e-12	0.87459004	[0.84-0.91]	D2HGDH	36344522	Jia G	Nat Commun	44,383 European ancestry cases, 260,715 European ancestry controls	GCST90244765
rs1837253	asthma	5	111066174	9e-11	0.8824969	[0.85-0.92]	BCLAF1P1 - TSLP	36344522	Jia G	Nat Commun	44,383 European ancestry cases, 260,715 European ancestry controls	GCST90244765
rs992969	asthma	9	6209697	6e-12	1.1376901	[1.1-1.17]	GTF3AP1 - IL33	36344522	Jia G	Nat Commun	44,383 European ancestry cases, 260,715 European ancestry controls	GCST90244765
rs992969	asthma	9	6209697	4e-47	1.12637	[1.11-1.14]	GTF3AP1 - IL33	36344522	Jia G	Nat Commun	44,383 European ancestry cases, 260,715 European ancestry controls	GCST90244761
rs10797119	C-reactive protein measurement	9	89587580	2e-19	0.0183	[0.014-0.022] unit decrease	SEMA4D - GADD45G	36376304	Koskeridis F	Nat Commun	575,531 European ancestry individuals	GCST90179146
rs10797119	executive function measurement	9	89587580	2e-10	NA		SEMA4D - GADD45G	36150907	Hatoum AS	Biol Psychiatry	427,037 European ancestry individuals	GCST90162547
rs216210	risk-taking behaviour	17	2325773	1e-08	NA		TSR1	36324656	Baselmans B	Biol Psychiatry Glob Open Sci	1,506,537 European ancestry individuals	GCST90239693
rs6679677	juvenile idiopathic arthritis	1	113761186	2e-06	NA		PHTF1 - RSBN1	35347896	Li J	Arthritis Rheumatol	1,245 European ancestry cases, 9,250 European ancestry controls	GCST90239777
rs12631337	attention deficit hyperactivity disorder, autism spectrum disorder, intelligence	3	50161104	4e-13	NA		SEMA3F	35764056	Rao S	Neuropsychobiology	20,183 European ancestry ADHD cases, 18,381 European ancestry ASD cases, up to 63,160 European ancestry controls, 269,867 European ancestry individuals with intelligence measurements	GCST90134330
rs1837253	asthma	5	111066174	2e-09	0.17760453	unit increase	BCLAF1P1 - TSLP	36329257	Lee CJ	Commun Biol	2,641 Taiwanese ancestry cases, 67,097 Taiwanese ancestry controls	GCST90239642
rs6679677	basal cell carcinoma	1	113761186	2e-68	NA		PHTF1 - RSBN1	36496446	Seviiri M	Nat Commun	20,791 European ancestry cases, 286,893 European ancestry controls	GCST90137411
rs1837253	chronic obstructive pulmonary disease	5	111066174	3e-09	0.0135907	[0.0089-0.0183] unit decrease	BCLAF1P1 - TSLP	37069358	Cosentino J	Nat Genet	325,027 European ancestry individuals	GCST90244098
rs12935657	age of onset of childhood onset asthma	16	11125184	3e-27	0.13661	[0.11-0.16] unit decrease	CLEC16A	36778051	Tsuo K	Cell Genom	20,964 European ancestry cases, 674,014 European ancestry controls	GCST90255669
rs5743618	age of onset of childhood onset asthma	4	38797027	5e-36	0.1707	[0.14-0.2] unit decrease	TLR1	36778051	Tsuo K	Cell Genom	20,964 European ancestry cases, 674,014 European ancestry controls	GCST90255669
rs1837253	age of onset of childhood onset asthma	5	111066174	8e-41	0.16512	[0.14-0.19] unit increase	BCLAF1P1 - TSLP	36778051	Tsuo K	Cell Genom	20,964 European ancestry cases, 674,014 European ancestry controls	GCST90255669
rs2070901	age of onset of childhood onset asthma	1	161215268	2e-08	0.066391	[0.043-0.09] unit increase	FCER1G	36778051	Tsuo K	Cell Genom	20,964 European ancestry cases, 674,014 European ancestry controls	GCST90255669
rs34290285	age of onset of childhood onset asthma	2	241759225	1e-34	0.15369	[0.13-0.18] unit decrease	D2HGDH	36778051	Tsuo K	Cell Genom	20,964 European ancestry cases, 674,014 European ancestry controls	GCST90255669
rs703816	migraine disorder, Headache	12	57103222	7e-22	NA		STAT6	36939796	Meng W	Phenomics	397,385 European ancestry individuals	GCST90267554
rs11154801	vital capacity	6	135418217	4e-12	NA		AHI1	36641522	Sinkala M	Commun Biol	383,471 European ancestry individuals	GCST90270083
rs34712979	peak expiratory flow	4	105897896	4e-18	NA		NPNT	36641522	Sinkala M	Commun Biol	383,471 European ancestry individuals	GCST90270085
rs1837253	upper respiratory tract disorder	5	111066174	7e-09	1.05	[1.03-1.07]	BCLAF1P1 - TSLP	36653354	Saarentaus EC	Nat Commun	61,197 Finnish ancestry cases, 199,208 Finnish ancestry controls	GCST90269783
rs17293632	upper respiratory tract disorder	15	67150258	3e-08	1.05	[1.02-1.07]	SMAD3	36653354	Saarentaus EC	Nat Commun	61,197 Finnish ancestry cases, 199,208 Finnish ancestry controls	GCST90269783
rs17293632	nasal disorder	15	67150258	3e-08	1.07		SMAD3	36653354	Saarentaus EC	Nat Commun	25,235 Finnish ancestry cases, 199,208 Finnish ancestry controls	GCST90269786
rs17293632	rhinitis	15	67150258	3e-11	1.02	[1.01-1.03]	SMAD3	36653354	Saarentaus EC	Nat Commun	at least 8,975 Finnish ancestry cases, 199,208 Finnish ancestry controls (MTAG boosted by additional inflammatory and infectious upper respiratory disease samples)	GCST90269787
rs1837253	upper respiratory tract disorder	5	111066174	1e-08	1.01	[1.0-1.02]	BCLAF1P1 - TSLP	36653354	Saarentaus EC	Nat Commun	at least 6,518 Finnish ancestry cases, 199,208 Finnish ancestry controls (MTAG boosted by additional inflammatory and infectious upper respiratory disease samples)	GCST90269788
rs1837253	chronic rhinosinusitis	5	111066174	2e-19	1.03	[1.02-1.04]	BCLAF1P1 - TSLP	36653354	Saarentaus EC	Nat Commun	at least 10,435 Finnish ancestry cases, 199,208 Finnish ancestry controls (MTAG boosted by additional inflammatory and infectious upper respiratory disease samples)	GCST90269789
rs17293632	nasal disorder	15	67150258	6e-09	1.01	[1.0-1.02]	SMAD3	36653354	Saarentaus EC	Nat Commun	at least 7,716 Finnish ancestry cases, 199,208 Finnish ancestry controls (MTAG boosted by additional inflammatory and infectious upper respiratory disease samples)	GCST90269791
rs7200879	suicidal ideation, suicide behaviour	16	30936251	4e-08	NA		FBXL19	36515925	Kimbrel NA	JAMA Psychiatry	75,941 European ancestry cases, 376,826 European ancestry controls	GCST90246334
rs34712979	chronic obstructive pulmonary disease	4	105897896	6e-161	0.0633781	[0.059-0.068] unit decrease	NPNT	37069358	Cosentino J	Nat Genet	325,027 European ancestry individuals	GCST90244098
rs17293632	chronic obstructive pulmonary disease	15	67150258	5e-11	0.0159369	[0.011-0.021] unit decrease	SMAD3	37069358	Cosentino J	Nat Genet	325,027 European ancestry individuals	GCST90244098
rs659398	chronic obstructive pulmonary disease	8	102119072	1e-18	0.0206053	[0.016-0.025] unit increase	NCALD	37069358	Cosentino J	Nat Genet	325,027 European ancestry individuals	GCST90244098
rs1837253	asthma	5	111066174	4e-104	0.10182	[0.093-0.111] unit increase	BCLAF1P1 - TSLP	36778051	Tsuo K	Cell Genom	5,051 African ancestry cases, 27,607 African ancestry controls, 4,069 Hispanic or Latin American cases, 14,104 Hispanic or Latin American controls, 4,015 Central Asian ancestry cases, 27,091 Central Asian ancestry controls, 4,015 South Asian ancestry cases, 27,091 South Asian ancestry controls, 18,549 East Asian ancestry cases, 322,655 East Asian ancestry controls, 121,940 European ancestry cases, 1,254,131 European ancestry controls, 139 Greater Middle Eastern (Middle Eastern, North African or Persian) cases, 1,434 Greater Middle Eastern (Middle Eastern, North African or Persian) controls	GCST90255667
rs34290285	age of onset of asthma	2	241759225	9e-27	0.081912	[0.067-0.097] unit decrease	D2HGDH	36778051	Tsuo K	Cell Genom	56,744 European ancestry cases, 674,014 European ancestry controls	GCST90255668
rs1837253	age of onset of asthma	5	111066174	1e-34	0.091945	[0.077-0.107] unit increase	BCLAF1P1 - TSLP	36778051	Tsuo K	Cell Genom	56,744 European ancestry cases, 674,014 European ancestry controls	GCST90255668
rs10995245	narcolepsy-cataplexy syndrome	10	62631615	3e-12	0.147	[0.11-0.19] unit increase	LINC02929	37188663	Ollila HM	Nat Commun	213 African American or Afro-Caribbean cases, 1,747 African American or Afro-Caribbean controls, 2,412 East Asian ancestry cases, 5,902 East Asian ancestry controls, 3,448 European ancestry cases, 77,207 European ancestry controls	GCST90293089
rs56154344	sexual dimorphism measurement	6	35167194	5e-14	NA		TCP11 - SCUBE3	37277458	Vosberg DE	Sci Rep	141,980 European ancestry males	GCST90270118
rs6679677	wellbeing measurement	1	113761186	7e-13	0.024785	[0.018-0.032] unit increase	PHTF1 - RSBN1	37704630	Lee J	Nat Commun	373,160 European ancestry individuals	GCST90292604
rs5743618	leukocyte count, response to stimulus	4	38797027	8e-103	NA		TLR1	38049662	Homilius M	Nat Genet	1,400 European ancestry individuals	GCST90257101
rs61779328	sexual dimorphism measurement	1	39487795	2e-15	NA		MACF1 - BMP8A	37277458	Vosberg DE	Sci Rep	161,906 European ancestry females	GCST90270116
rs1837253	vasculitis	5	111066174	8e-09	0.65	[0.56-0.75]	BCLAF1P1 - TSLP	36797040	Ortiz-Fernandez L	Ann Rheum Dis	8,467 European, Turkish, Asian or Middle Eastern ancestry cases, 29,795 European, Turkish, Asian or Middle Eastern ancestry controls	GCST90271348
rs56154344	sexual dimorphism measurement	6	35167194	2e-12	NA		TCP11 - SCUBE3	37277458	Vosberg DE	Sci Rep	161,906 European ancestry females	GCST90270116
rs34712979	protein measurement	4	105897896	1e-27	0.172	[0.14-0.2] unit decrease	NPNT	34648354	Pietzner M	Science	10,708 European ancestry individuals	GCST90248641
rs5743618	toll-like receptor 1 measurement	4	38797027	5e-14	0.113	[0.084-0.142] unit increase	TLR1	34648354	Pietzner M	Science	10,708 European ancestry individuals	GCST90249892
rs6679677	myositis	1	113761186	2e-07	1.3	[1.19-1.43]	PHTF1 - RSBN1	36580032	Rothwell S	Arthritis Rheumatol	2,565 European ancestry cases, 10,260 European ancestry controls	GCST90270216
rs34712979	FEV/FVC ratio	4	105897896	9e-141	25.258	z score decrease	NPNT	36914875	Shrine N	Nat Genet	475,645 European ancestry individuals, 8,590 African ancestry individuals, 85,279 East Asian ancestry individuals, 4,270 South Asian ancestry individuals, 14,668 Hispanic or Latin American individuals	GCST90244094
rs659398	FEV/FVC ratio	8	102119072	2e-23	9.959	z score decrease	NCALD	36914875	Shrine N	Nat Genet	475,645 European ancestry individuals, 8,590 African ancestry individuals, 85,279 East Asian ancestry individuals, 4,270 South Asian ancestry individuals, 14,668 Hispanic or Latin American individuals	GCST90244094
rs17293632	body height	15	67150258	8e-47	0.013	[0.011-0.015] unit increase	SMAD3	36224396	Yengo L	Nature	5,314,291 European ancestry, Hispanic or Latin American, East Asian ancestry, African ancestry, South Asian ancestry individuals	GCST90245848
