

# Two sample MR report

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## Asthma || id:ebi-a-GCST90018795 against Type 2 diabetes (adjusted for BMI) || id:ebi-a-GCST90093110

Date: **28 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|      b|    se|  pval|
|:-------------------------|----:|------:|-----:|-----:|
|MR Egger                  |  105| -0.062| 0.111| 0.578|
|Weighted median           |  105| -0.010| 0.052| 0.851|
|Inverse variance weighted |  105|  0.006| 0.040| 0.876|
|Simple mode               |  105|  0.078| 0.113| 0.489|
|Weighted mode             |  105|  0.032| 0.074| 0.661|

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### Heterogeneity tests


|method                    |   Q| Q_df| Q_pval|
|:-------------------------|---:|----:|------:|
|MR Egger                  | 136|  103|  0.017|
|Inverse variance weighted | 136|  104|  0.018|

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### Test for directional horizontal pleiotropy


| egger_intercept|    se|  pval|
|---------------:|-----:|-----:|
|           0.004| 0.006| 0.512|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |        0.874|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Asthma__idebiaGCST90018795_against_Type_2_diabetes_adjusted_for_BMI__idebiaGCST90093110chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Asthma__idebiaGCST90018795_against_Type_2_diabetes_adjusted_for_BMI__idebiaGCST90093110chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Asthma__idebiaGCST90018795_against_Type_2_diabetes_adjusted_for_BMI__idebiaGCST90093110chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Asthma__idebiaGCST90018795_against_Type_2_diabetes_adjusted_for_BMI__idebiaGCST90093110chunk8-1.png)
