Two sample MR report
Asthma || id:ebi-a-GCST90018795 against Type 2 diabetes (adjusted for BMI) || id:ebi-a-GCST90093110
Date: 28 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 105 | -0.062 | 0.111 | 0.578 |
| Weighted median | 105 | -0.010 | 0.052 | 0.851 |
| Inverse variance weighted | 105 | 0.006 | 0.040 | 0.876 |
| Simple mode | 105 | 0.078 | 0.113 | 0.489 |
| Weighted mode | 105 | 0.032 | 0.074 | 0.661 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 136 | 103 | 0.017 |
| Inverse variance weighted | 136 | 104 | 0.018 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.004 | 0.006 | 0.512 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.874 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
