

# Two sample MR report

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## genus.Clostridiumsensustricto1.id.1873 against BK polyomavirus seropositivity

Date: **22 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    9| 1.6026458| 0.8205462| 0.0917415|
|Weighted median           |    9| 1.1199647| 0.4872462| 0.0215299|
|Inverse variance weighted |    9| 0.7500548| 0.3707188| 0.0430479|
|Simple mode               |    9| 1.1122880| 0.6813812| 0.1412386|
|Weighted mode             |    9| 1.1621702| 0.6185345| 0.0970682|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.290218|    7| 0.8569202|
|Inverse variance weighted | 4.646741|    8| 0.7945789|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.0981678| 0.084286| 0.2822935|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        1.89e-05|          2e-07|TRUE                     |    0.7862475|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/genusClostridiumsensustricto1id1873_against_BK_polyomavirus_seropositivitychunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/genusClostridiumsensustricto1id1873_against_BK_polyomavirus_seropositivitychunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/genusClostridiumsensustricto1id1873_against_BK_polyomavirus_seropositivitychunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/genusClostridiumsensustricto1id1873_against_BK_polyomavirus_seropositivitychunk8-1.png)
