

# Two sample MR report

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## genus.Eggerthella.id.819 against BK polyomavirus seropositivity

Date: **22 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   11| 0.3698592| 1.1345259| 0.7518742|
|Weighted median           |   11| 0.2543501| 0.3228635| 0.4308169|
|Inverse variance weighted |   11| 0.5226502| 0.2434437| 0.0318009|
|Simple mode               |   11| 0.0859509| 0.5091806| 0.8693175|
|Weighted mode             |   11| 0.0859509| 0.4796613| 0.8613664|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 7.717842|    9| 0.5628119|
|Inverse variance weighted | 7.736854|   10| 0.6545230|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       0.0170502| 0.123655| 0.8933664|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001814|          5e-07|TRUE                     |    0.4728776|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/genusEggerthellaid819_against_BK_polyomavirus_seropositivitychunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/genusEggerthellaid819_against_BK_polyomavirus_seropositivitychunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/genusEggerthellaid819_against_BK_polyomavirus_seropositivitychunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/genusEggerthellaid819_against_BK_polyomavirus_seropositivitychunk8-1.png)
