

# Two sample MR report

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## genus.Methanobrevibacter.id.123 against VP1

Date: **20 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    8| 0.1156105| 0.1855940| 0.5562565|
|Weighted median           |    8| 0.1304383| 0.0628675| 0.0380039|
|Inverse variance weighted |    8| 0.1352651| 0.0493858| 0.0061637|
|Simple mode               |    8| 0.1263358| 0.0984149| 0.2401020|
|Weighted mode             |    8| 0.1269978| 0.0912120| 0.2064500|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.625606|    6| 0.9507189|
|Inverse variance weighted | 1.637676|    7| 0.9771572|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0027948| 0.0254389| 0.9161014|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002717|          3e-07|TRUE                     |    0.4275343|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/genusMethanobrevibacterid123_against_VP1chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/genusMethanobrevibacterid123_against_VP1chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/genusMethanobrevibacterid123_against_VP1chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/genusMethanobrevibacterid123_against_VP1chunk8-1.png)
