

# Two sample MR report

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## family.Actinomycetaceae.id.421 against BK polyomavirus seropositivity

Date: **22 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 1.0541366| 1.0413745| 0.3859658|
|Weighted median           |    5| 0.7600715| 0.5182108| 0.1424515|
|Inverse variance weighted |    5| 0.9369660| 0.4010035| 0.0194624|
|Simple mode               |    5| 0.7965516| 0.7093744| 0.3243224|
|Weighted mode             |    5| 0.7583802| 0.6411056| 0.3023445|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.969276|    3| 0.5788081|
|Inverse variance weighted | 1.984139|    4| 0.7386763|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0129144| 0.1059281| 0.9106731|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.81e-05|          3e-07|TRUE                     |     0.729127|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/familyActinomycetaceaeid421_against_BK_polyomavirus_seropositivitychunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/familyActinomycetaceaeid421_against_BK_polyomavirus_seropositivitychunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/familyActinomycetaceaeid421_against_BK_polyomavirus_seropositivitychunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/familyActinomycetaceaeid421_against_BK_polyomavirus_seropositivitychunk8-1.png)
