

# Two sample MR report

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## genus.unknowngenus.id.1000005479 against VP1

Date: **20 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    9| -0.1006279| 0.3193592| 0.7618761|
|Weighted median           |    9| -0.1255911| 0.0859685| 0.1440439|
|Inverse variance weighted |    9| -0.1354176| 0.0670873| 0.0435364|
|Simple mode               |    9| -0.1763142| 0.1350056| 0.2278593|
|Weighted mode             |    9| -0.1614113| 0.1385435| 0.2775568|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.652340|    7| 0.8188363|
|Inverse variance weighted | 3.664755|    8| 0.8860338|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0034204| 0.0306973| 0.9144093|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        7.38e-05|          2e-07|TRUE                     |    0.6099554|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/genusunknowngenusid1000005479_against_VP1chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/genusunknowngenusid1000005479_against_VP1chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/genusunknowngenusid1000005479_against_VP1chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/genusunknowngenusid1000005479_against_VP1chunk8-1.png)
