

# Two sample MR report

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## genus.RuminococcaceaeUCG011.id.11368 against VP1

Date: **20 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    8| 0.2351389| 0.3299622| 0.5028368|
|Weighted median           |    8| 0.1039694| 0.0689419| 0.1315357|
|Inverse variance weighted |    8| 0.1257565| 0.0592964| 0.0339375|
|Simple mode               |    8| 0.2246265| 0.1139855| 0.0894042|
|Weighted mode             |    8| 0.0802315| 0.1009093| 0.4526751|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  |  9.949608|    6| 0.1267903|
|Inverse variance weighted | 10.138835|    7| 0.1808414|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0146415| 0.0433433| 0.7470165|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003137|          9e-07|TRUE                     |    0.4000987|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/genusRuminococcaceaeUCG011id11368_against_VP1chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/genusRuminococcaceaeUCG011id11368_against_VP1chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/genusRuminococcaceaeUCG011id11368_against_VP1chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/genusRuminococcaceaeUCG011id11368_against_VP1chunk8-1.png)
