

# Two sample MR report

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## class.Methanobacteria.id.119 against VP1

Date: **20 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   12| 0.0998692| 0.1684789| 0.5664980|
|Weighted median           |   12| 0.1234504| 0.0556881| 0.0266355|
|Inverse variance weighted |   12| 0.1240225| 0.0416200| 0.0028836|
|Simple mode               |   12| 0.1577664| 0.0935131| 0.1197013|
|Weighted mode             |   12| 0.1481392| 0.0947859| 0.1463734|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 11.94955|   10| 0.2884469|
|Inverse variance weighted | 11.97588|   11| 0.3654593|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0039587| 0.0266724| 0.8849633|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004117|        1.1e-06|TRUE                     |    0.3421135|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/classMethanobacteriaid119_against_VP1chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/classMethanobacteriaid119_against_VP1chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/classMethanobacteriaid119_against_VP1chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/classMethanobacteriaid119_against_VP1chunk8-1.png)
