

# Two sample MR report

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## genus.LachnospiraceaeUCG004.id.11324 against BK polyomavirus seropositivity

Date: **22 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   13| -1.1278291| 1.3507366| 0.4214974|
|Weighted median           |   13|  0.4867911| 0.4609110| 0.2908997|
|Inverse variance weighted |   13|  0.7769665| 0.3605008| 0.0311429|
|Simple mode               |   13|  0.1993985| 0.8362173| 0.8155532|
|Weighted mode             |   13|  0.1993985| 0.8190970| 0.8117787|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.077997|   11| 0.9273304|
|Inverse variance weighted | 7.219151|   12| 0.8427978|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       0.1326204| 0.090633| 0.1713743|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.81e-05|          3e-07|TRUE                     |    0.7282821|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/genusLachnospiraceaeUCG004id11324_against_BK_polyomavirus_seropositivitychunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/genusLachnospiraceaeUCG004id11324_against_BK_polyomavirus_seropositivitychunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/genusLachnospiraceaeUCG004id11324_against_BK_polyomavirus_seropositivitychunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/genusLachnospiraceaeUCG004id11324_against_BK_polyomavirus_seropositivitychunk8-1.png)
