

# Two sample MR report

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## genus..Eubacteriumoxidoreducensgroup.id.11339 against VP1

Date: **20 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.0833086| 0.2579163| 0.7678946|
|Weighted median           |    5| -0.1352664| 0.1004737| 0.1782101|
|Inverse variance weighted |    5| -0.1812253| 0.0745245| 0.0150259|
|Simple mode               |    5| -0.1155303| 0.1277023| 0.4167946|
|Weighted mode             |    5| -0.1239504| 0.1190951| 0.3567527|

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### Heterogeneity tests


|method                    |       Q| Q_df|    Q_pval|
|:-------------------------|-------:|----:|---------:|
|MR Egger                  | 2.14500|    3| 0.5428627|
|Inverse variance weighted | 2.30226|    4| 0.6803575|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0105817| 0.0266838| 0.7182161|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        8.01e-05|          4e-07|TRUE                     |    0.6396955|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/genusEubacteriumoxidoreducensgroupid11339_against_VP1chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/genusEubacteriumoxidoreducensgroupid11339_against_VP1chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/genusEubacteriumoxidoreducensgroupid11339_against_VP1chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/genusEubacteriumoxidoreducensgroupid11339_against_VP1chunk8-1.png)
