

# Two sample MR report

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## genus.LachnospiraceaeUCG010.id.11330 against VP1

Date: **20 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   11| 0.2231743| 0.2021524| 0.2982381|
|Weighted median           |   11| 0.1804289| 0.0977721| 0.0649791|
|Inverse variance weighted |   11| 0.2097006| 0.0759215| 0.0057436|
|Simple mode               |   11| 0.1397338| 0.1577329| 0.3964808|
|Weighted mode             |   11| 0.1417365| 0.1509893| 0.3699945|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.780855|    9| 0.8529780|
|Inverse variance weighted | 4.786026|   10| 0.9050056|

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### Test for directional horizontal pleiotropy


| egger_intercept|      se|      pval|
|---------------:|-------:|---------:|
|      -0.0011852| 0.01648| 0.9442416|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.93e-05|          5e-07|TRUE                     |    0.7424042|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/genusLachnospiraceaeUCG010id11330_against_VP1chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/genusLachnospiraceaeUCG010id11330_against_VP1chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/genusLachnospiraceaeUCG010id11330_against_VP1chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/genusLachnospiraceaeUCG010id11330_against_VP1chunk8-1.png)
