

# Two sample MR report

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## genus.Catenibacterium.id.2153 against BK polyomavirus seropositivity

Date: **22 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5|  3.0605349| 2.5288201| 0.3128372|
|Weighted median           |    5| -0.8359018| 0.3927251| 0.0332985|
|Inverse variance weighted |    5| -0.6180414| 0.2789057| 0.0266949|
|Simple mode               |    5| -0.9901671| 0.5152153| 0.1270006|
|Weighted mode             |    5| -1.0019272| 0.5747539| 0.1562474|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.362156|    3| 0.7144291|
|Inverse variance weighted | 3.504252|    4| 0.4772322|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.4963631| 0.3391408| 0.2395077|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002124|          3e-07|TRUE                     |    0.4970939|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/genusCatenibacteriumid2153_against_BK_polyomavirus_seropositivitychunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/genusCatenibacteriumid2153_against_BK_polyomavirus_seropositivitychunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/genusCatenibacteriumid2153_against_BK_polyomavirus_seropositivitychunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/genusCatenibacteriumid2153_against_BK_polyomavirus_seropositivitychunk8-1.png)
