

# Two sample MR report

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## genus.Intestinibacter.id.11345 against VP1

Date: **20 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   15| 0.1784924| 0.2160961| 0.4237120|
|Weighted median           |   15| 0.1394284| 0.0908676| 0.1249284|
|Inverse variance weighted |   15| 0.1599172| 0.0655508| 0.0147038|
|Simple mode               |   15| 0.1694272| 0.1583204| 0.3026538|
|Weighted mode             |   15| 0.1648886| 0.1605717| 0.3218912|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 7.837717|   13| 0.8540096|
|Inverse variance weighted | 7.845854|   14| 0.8972010|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0015519| 0.0172038| 0.9294966|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.82e-05|          6e-07|TRUE                     |    0.6678481|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/genusIntestinibacterid11345_against_VP1chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/genusIntestinibacterid11345_against_VP1chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/genusIntestinibacterid11345_against_VP1chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/genusIntestinibacterid11345_against_VP1chunk8-1.png)
