

# Two sample MR report

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## genus.Alistipes.id.968 against VP1

Date: **20 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   15| -0.0415702| 0.4135179| 0.9214589|
|Weighted median           |   15|  0.1747368| 0.1085417| 0.1074288|
|Inverse variance weighted |   15|  0.1792198| 0.0824474| 0.0297241|
|Simple mode               |   15|  0.3204180| 0.1871733| 0.1089712|
|Weighted mode             |   15|  0.3154610| 0.2005260| 0.1380012|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.385598|   13| 0.9656954|
|Inverse variance weighted | 5.682482|   14| 0.9738711|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0132975| 0.0244049| 0.5950667|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.07e-05|          2e-07|TRUE                     |    0.7602915|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/genusAlistipesid968_against_VP1chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/genusAlistipesid968_against_VP1chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/genusAlistipesid968_against_VP1chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/genusAlistipesid968_against_VP1chunk8-1.png)
