

# Two sample MR report

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## genus.Adlercreutzia.id.812 against VP1

Date: **20 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   12| -0.0461193| 0.3005446| 0.8810939|
|Weighted median           |   12|  0.1254300| 0.0769732| 0.1032014|
|Inverse variance weighted |   12|  0.1486452| 0.0623072| 0.0170475|
|Simple mode               |   12|  0.1198662| 0.1271638| 0.3661211|
|Weighted mode             |   12|  0.1181854| 0.1219013| 0.3531224|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.476548|   10| 0.9232997|
|Inverse variance weighted | 4.915362|   11| 0.9351961|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0184968| 0.0279226| 0.5226688|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        8.01e-05|          4e-07|TRUE                     |    0.5941546|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/genusAdlercreutziaid812_against_VP1chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/genusAdlercreutziaid812_against_VP1chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/genusAdlercreutziaid812_against_VP1chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/genusAdlercreutziaid812_against_VP1chunk8-1.png)
