

# Two sample MR report

---

## Depressed affect || id:ebi-a-GCST006475 against Hypertension || id:ebi-a-GCST90038604

Date: **26 November, 2025**

---

### Results from two sample MR:


|method                    | nsnp|      b|    se|  pval|
|:-------------------------|----:|------:|-----:|-----:|
|MR Egger                  |   59| -0.072| 0.076| 0.345|
|Weighted median           |   59|  0.031| 0.013| 0.018|
|Inverse variance weighted |   59|  0.024| 0.016| 0.142|
|Simple mode               |   59|  0.054| 0.028| 0.063|
|Weighted mode             |   59|  0.052| 0.029| 0.076|

---

### Heterogeneity tests


|method                    |   Q| Q_df| Q_pval|
|:-------------------------|---:|----:|------:|
|MR Egger                  | 267|   57|      0|
|Inverse variance weighted | 275|   58|      0|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|    se|  pval|
|---------------:|-----:|-----:|
|           0.002| 0.001| 0.199|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |        0.775|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Depressed_affect__idebiaGCST006475_against_Hypertension__idebiaGCST90038604chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Depressed_affect__idebiaGCST006475_against_Hypertension__idebiaGCST90038604chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/Depressed_affect__idebiaGCST006475_against_Hypertension__idebiaGCST90038604chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Depressed_affect__idebiaGCST006475_against_Hypertension__idebiaGCST90038604chunk8-1.png)
