

# Two sample MR report

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## Waist-to-hip ratio adjusted for BMI || id:ebi-a-GCST90025996 against Diabetic nephropathy || id:ebi-a-GCST90018832

Date: **27 November, 2025**

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### Results from two sample MR:


|method                    | nsnp|     b|    se|  pval|
|:-------------------------|----:|-----:|-----:|-----:|
|MR Egger                  |  231| 0.300| 0.505| 0.554|
|Weighted median           |  231| 0.668| 0.276| 0.016|
|Inverse variance weighted |  231| 0.561| 0.196| 0.004|
|Simple mode               |  231| 0.640| 0.782| 0.414|
|Weighted mode             |  231| 0.776| 0.524| 0.140|

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### Heterogeneity tests


|method                    |   Q| Q_df| Q_pval|
|:-------------------------|---:|----:|------:|
|MR Egger                  | 341|  229|      0|
|Inverse variance weighted | 342|  230|      0|

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### Test for directional horizontal pleiotropy


| egger_intercept|   se|  pval|
|---------------:|----:|-----:|
|           0.006| 0.01| 0.575|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |        0.063|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Waisttohip_ratio_adjusted_for_BMI__idebiaGCST90025996_against_Diabetic_nephropathy__idebiaGCST90018832chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Waisttohip_ratio_adjusted_for_BMI__idebiaGCST90025996_against_Diabetic_nephropathy__idebiaGCST90018832chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Waisttohip_ratio_adjusted_for_BMI__idebiaGCST90025996_against_Diabetic_nephropathy__idebiaGCST90018832chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Waisttohip_ratio_adjusted_for_BMI__idebiaGCST90025996_against_Diabetic_nephropathy__idebiaGCST90018832chunk8-1.png)
