

# Two sample MR report

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## Depressed affect || id:ebi-a-GCST006475 against Diabetic nephropathy || id:ebi-a-GCST90018832

Date: **27 November, 2025**

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### Results from two sample MR:


|method                    | nsnp|     b|    se|  pval|
|:-------------------------|----:|-----:|-----:|-----:|
|MR Egger                  |   59| 1.258| 2.058| 0.543|
|Weighted median           |   59| 1.311| 0.615| 0.033|
|Inverse variance weighted |   59| 0.897| 0.428| 0.036|
|Simple mode               |   59| 1.577| 1.411| 0.268|
|Weighted mode             |   59| 1.534| 1.301| 0.243|

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### Heterogeneity tests


|method                    |    Q| Q_df| Q_pval|
|:-------------------------|----:|----:|------:|
|MR Egger                  | 66.6|   57|  0.181|
|Inverse variance weighted | 66.6|   58|  0.205|

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### Test for directional horizontal pleiotropy


| egger_intercept|    se|  pval|
|---------------:|-----:|-----:|
|          -0.006| 0.033| 0.858|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |         0.71|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Depressed_affect__idebiaGCST006475_against_Diabetic_nephropathy__idebiaGCST90018832chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Depressed_affect__idebiaGCST006475_against_Diabetic_nephropathy__idebiaGCST90018832chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Depressed_affect__idebiaGCST006475_against_Diabetic_nephropathy__idebiaGCST90018832chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Depressed_affect__idebiaGCST006475_against_Diabetic_nephropathy__idebiaGCST90018832chunk8-1.png)
