

# Two sample MR report

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## Systolic blood pressure || id:ebi-a-GCST90025968 against Diabetic nephropathy || id:ebi-a-GCST90018832

Date: **26 November, 2025**

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### Results from two sample MR:


|method                    | nsnp|     b|    se|  pval|
|:-------------------------|----:|-----:|-----:|-----:|
|MR Egger                  |  413| 0.751| 0.590| 0.204|
|Weighted median           |  413| 0.605| 0.250| 0.016|
|Inverse variance weighted |  413| 0.605| 0.171| 0.000|
|Simple mode               |  413| 0.948| 0.883| 0.284|
|Weighted mode             |  413| 0.879| 0.793| 0.268|

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### Heterogeneity tests


|method                    |   Q| Q_df| Q_pval|
|:-------------------------|---:|----:|------:|
|MR Egger                  | 446|  411|  0.115|
|Inverse variance weighted | 446|  412|  0.122|

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### Test for directional horizontal pleiotropy


| egger_intercept|    se|  pval|
|---------------:|-----:|-----:|
|          -0.002| 0.009| 0.796|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |        0.382|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Systolic_blood_pressure__idebiaGCST90025968_against_Diabetic_nephropathy__idebiaGCST90018832chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Systolic_blood_pressure__idebiaGCST90025968_against_Diabetic_nephropathy__idebiaGCST90018832chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Systolic_blood_pressure__idebiaGCST90025968_against_Diabetic_nephropathy__idebiaGCST90018832chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Systolic_blood_pressure__idebiaGCST90025968_against_Diabetic_nephropathy__idebiaGCST90018832chunk8-1.png)
