

# Two sample MR report

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## Depressed affect || id:ebi-a-GCST006475 against Waist-to-hip ratio adjusted for BMI || id:ebi-a-GCST90025996

Date: **27 November, 2025**

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### Results from two sample MR:


|method                    | nsnp|     b|    se|  pval|
|:-------------------------|----:|-----:|-----:|-----:|
|MR Egger                  |   31| 0.657| 0.208| 0.004|
|Weighted median           |   31| 0.135| 0.039| 0.000|
|Inverse variance weighted |   31| 0.198| 0.055| 0.000|
|Simple mode               |   31| 0.127| 0.069| 0.076|
|Weighted mode             |   31| 0.133| 0.065| 0.049|

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### Heterogeneity tests


|method                    |   Q| Q_df| Q_pval|
|:-------------------------|---:|----:|------:|
|MR Egger                  | 123|   29|      0|
|Inverse variance weighted | 145|   30|      0|

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### Test for directional horizontal pleiotropy


| egger_intercept|    se| pval|
|---------------:|-----:|----:|
|          -0.008| 0.004| 0.03|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |        0.851|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Depressed_affect__idebiaGCST006475_against_Waisttohip_ratio_adjusted_for_BMI__idebiaGCST90025996chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Depressed_affect__idebiaGCST006475_against_Waisttohip_ratio_adjusted_for_BMI__idebiaGCST90025996chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Depressed_affect__idebiaGCST006475_against_Waisttohip_ratio_adjusted_for_BMI__idebiaGCST90025996chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Depressed_affect__idebiaGCST006475_against_Waisttohip_ratio_adjusted_for_BMI__idebiaGCST90025996chunk8-1.png)
