

# Two sample MR report

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## Osteoarthritis of the hip (hospital diagnosed) || id:ebi-a-GCST005810 against Body mass index (BMI) || id:ukb-b-2303

Date: **28 November, 2025**

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### Results from two sample MR:


|method                    | nsnp|      b|    se|  pval|
|:-------------------------|----:|------:|-----:|-----:|
|MR Egger                  |   16| -0.010| 0.012| 0.403|
|Weighted median           |   16|  0.008| 0.005| 0.108|
|Inverse variance weighted |   16|  0.005| 0.004| 0.212|
|Simple mode               |   16|  0.009| 0.010| 0.338|
|Weighted mode             |   16|  0.009| 0.009| 0.317|

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### Heterogeneity tests


|method                    |    Q| Q_df| Q_pval|
|:-------------------------|----:|----:|------:|
|MR Egger                  | 17.6|   14|  0.227|
|Inverse variance weighted | 19.7|   15|  0.184|

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### Test for directional horizontal pleiotropy


| egger_intercept|    se|  pval|
|---------------:|-----:|-----:|
|           0.003| 0.003| 0.215|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |        0.371|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Osteoarthritis_of_the_hip_hospital_diagnosed__idebiaGCST005810_against_Body_mass_index_BMI__idukbb2303chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Osteoarthritis_of_the_hip_hospital_diagnosed__idebiaGCST005810_against_Body_mass_index_BMI__idukbb2303chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Osteoarthritis_of_the_hip_hospital_diagnosed__idebiaGCST005810_against_Body_mass_index_BMI__idukbb2303chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Osteoarthritis_of_the_hip_hospital_diagnosed__idebiaGCST005810_against_Body_mass_index_BMI__idukbb2303chunk8-1.png)
