

# Two sample MR report

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## Depressed affect || id:ebi-a-GCST006475 against Systolic blood pressure || id:ebi-a-GCST90025968

Date: **26 November, 2025**

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### Results from two sample MR:


|method                    | nsnp|      b|    se|  pval|
|:-------------------------|----:|------:|-----:|-----:|
|MR Egger                  |   31| -0.307| 0.323| 0.350|
|Weighted median           |   31|  0.035| 0.048| 0.458|
|Inverse variance weighted |   31|  0.054| 0.081| 0.504|
|Simple mode               |   31|  0.042| 0.100| 0.677|
|Weighted mode             |   31|  0.048| 0.081| 0.556|

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### Heterogeneity tests


|method                    |   Q| Q_df| Q_pval|
|:-------------------------|---:|----:|------:|
|MR Egger                  | 282|   29|      0|
|Inverse variance weighted | 295|   30|      0|

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### Test for directional horizontal pleiotropy


| egger_intercept|    se|  pval|
|---------------:|-----:|-----:|
|           0.006| 0.005| 0.259|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |        0.878|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Depressed_affect__idebiaGCST006475_against_Systolic_blood_pressure__idebiaGCST90025968chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Depressed_affect__idebiaGCST006475_against_Systolic_blood_pressure__idebiaGCST90025968chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Depressed_affect__idebiaGCST006475_against_Systolic_blood_pressure__idebiaGCST90025968chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Depressed_affect__idebiaGCST006475_against_Systolic_blood_pressure__idebiaGCST90025968chunk8-1.png)
