

# Two sample MR report

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## Hypertension || id:ebi-a-GCST90038604 against Diabetic nephropathy || id:ebi-a-GCST90018832

Date: **26 November, 2025**

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### Results from two sample MR:


|method                    | nsnp|     b|    se|  pval|
|:-------------------------|----:|-----:|-----:|-----:|
|MR Egger                  |  237| 1.227| 1.063| 0.249|
|Weighted median           |  237| 1.094| 0.675| 0.105|
|Inverse variance weighted |  237| 1.571| 0.416| 0.000|
|Simple mode               |  237| 1.347| 1.785| 0.451|
|Weighted mode             |  237| 0.274| 1.248| 0.826|

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### Heterogeneity tests


|method                    |   Q| Q_df| Q_pval|
|:-------------------------|---:|----:|------:|
|MR Egger                  | 232|  235|  0.540|
|Inverse variance weighted | 232|  236|  0.556|

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### Test for directional horizontal pleiotropy


| egger_intercept|    se|  pval|
|---------------:|-----:|-----:|
|           0.003| 0.009| 0.725|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |        0.166|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Hypertension__idebiaGCST90038604_against_Diabetic_nephropathy__idebiaGCST90018832chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Hypertension__idebiaGCST90038604_against_Diabetic_nephropathy__idebiaGCST90018832chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Hypertension__idebiaGCST90038604_against_Diabetic_nephropathy__idebiaGCST90018832chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Hypertension__idebiaGCST90038604_against_Diabetic_nephropathy__idebiaGCST90018832chunk8-1.png)
