Two sample MR report
Depressed affect || id:ebi-a-GCST006475 against Diabetic nephropathy || id:ebi-a-GCST90018832
Date: 27 November, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 59 | 1.258 | 2.058 | 0.543 |
| Weighted median | 59 | 1.311 | 0.615 | 0.033 |
| Inverse variance weighted | 59 | 0.897 | 0.428 | 0.036 |
| Simple mode | 59 | 1.577 | 1.411 | 0.268 |
| Weighted mode | 59 | 1.534 | 1.301 | 0.243 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 66.6 | 57 | 0.181 |
| Inverse variance weighted | 66.6 | 58 | 0.205 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.006 | 0.033 | 0.858 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.71 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
