Two sample MR report
Depressed affect || id:ebi-a-GCST006475 against Systolic blood pressure || id:ebi-a-GCST90025968
Date: 26 November, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 31 | -0.307 | 0.323 | 0.350 |
| Weighted median | 31 | 0.035 | 0.048 | 0.458 |
| Inverse variance weighted | 31 | 0.054 | 0.081 | 0.504 |
| Simple mode | 31 | 0.042 | 0.100 | 0.677 |
| Weighted mode | 31 | 0.048 | 0.081 | 0.556 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 282 | 29 | 0 |
| Inverse variance weighted | 295 | 30 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.006 | 0.005 | 0.259 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.878 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
