Two sample MR report
Depressed affect || id:ebi-a-GCST006475 against Waist-to-hip ratio adjusted for BMI || id:ebi-a-GCST90025996
Date: 27 November, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 31 | 0.657 | 0.208 | 0.004 |
| Weighted median | 31 | 0.135 | 0.039 | 0.000 |
| Inverse variance weighted | 31 | 0.198 | 0.055 | 0.000 |
| Simple mode | 31 | 0.127 | 0.069 | 0.076 |
| Weighted mode | 31 | 0.133 | 0.065 | 0.049 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 123 | 29 | 0 |
| Inverse variance weighted | 145 | 30 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.008 | 0.004 | 0.03 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.851 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
