Two sample MR report
Depressed affect || id:ebi-a-GCST006475 against Hypertension || id:ebi-a-GCST90038604
Date: 26 November, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 59 | -0.072 | 0.076 | 0.345 |
| Weighted median | 59 | 0.031 | 0.013 | 0.018 |
| Inverse variance weighted | 59 | 0.024 | 0.016 | 0.142 |
| Simple mode | 59 | 0.054 | 0.028 | 0.063 |
| Weighted mode | 59 | 0.052 | 0.029 | 0.076 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 267 | 57 | 0 |
| Inverse variance weighted | 275 | 58 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.002 | 0.001 | 0.199 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.775 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
