Two sample MR report
Systolic blood pressure || id:ebi-a-GCST90025968 against Diabetic nephropathy || id:ebi-a-GCST90018832
Date: 26 November, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 413 | 0.751 | 0.590 | 0.204 |
| Weighted median | 413 | 0.605 | 0.250 | 0.016 |
| Inverse variance weighted | 413 | 0.605 | 0.171 | 0.000 |
| Simple mode | 413 | 0.948 | 0.883 | 0.284 |
| Weighted mode | 413 | 0.879 | 0.793 | 0.268 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 446 | 411 | 0.115 |
| Inverse variance weighted | 446 | 412 | 0.122 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.002 | 0.009 | 0.796 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.382 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
