Two sample MR report
Waist-to-hip ratio adjusted for BMI || id:ebi-a-GCST90025996 against Diabetic nephropathy || id:ebi-a-GCST90018832
Date: 27 November, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 231 | 0.300 | 0.505 | 0.554 |
| Weighted median | 231 | 0.668 | 0.276 | 0.016 |
| Inverse variance weighted | 231 | 0.561 | 0.196 | 0.004 |
| Simple mode | 231 | 0.640 | 0.782 | 0.414 |
| Weighted mode | 231 | 0.776 | 0.524 | 0.140 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 341 | 229 | 0 |
| Inverse variance weighted | 342 | 230 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.006 | 0.01 | 0.575 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.063 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
