Two sample MR report
Hypertension || id:ebi-a-GCST90038604 against Diabetic nephropathy || id:ebi-a-GCST90018832
Date: 26 November, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 237 | 1.227 | 1.063 | 0.249 |
| Weighted median | 237 | 1.094 | 0.675 | 0.105 |
| Inverse variance weighted | 237 | 1.571 | 0.416 | 0.000 |
| Simple mode | 237 | 1.347 | 1.785 | 0.451 |
| Weighted mode | 237 | 0.274 | 1.248 | 0.826 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 232 | 235 | 0.540 |
| Inverse variance weighted | 232 | 236 | 0.556 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.003 | 0.009 | 0.725 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.166 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
