Two sample MR report
Body mass index (BMI) || id:ukb-b-2303 against Osteoarthritis of the hip (hospital diagnosed) || id:ebi-a-GCST005810
Date: 28 November, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 666 | 0.805 | 0.240 | 0.001 |
| Weighted median | 666 | 0.449 | 0.165 | 0.006 |
| Inverse variance weighted | 666 | 0.652 | 0.091 | 0.000 |
| Simple mode | 666 | 0.153 | 0.547 | 0.780 |
| Weighted mode | 666 | 0.153 | 0.347 | 0.660 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 690 | 664 | 0.231 |
| Inverse variance weighted | 691 | 665 | 0.235 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.003 | 0.004 | 0.49 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.96 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
