Two sample MR report
Body mass index || id:ebi-a-GCST90103751 against Type 2 diabetes || id:ebi-a-GCST010118
Date: 25 November, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 11 | 0.628 | 0.859 | 0.484 |
| Weighted median | 11 | 0.190 | 0.077 | 0.013 |
| Inverse variance weighted | 11 | 0.143 | 0.147 | 0.331 |
| Simple mode | 11 | 0.125 | 0.103 | 0.252 |
| Weighted mode | 11 | 0.142 | 0.094 | 0.159 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 96.0 | 9 | 0 |
| Inverse variance weighted | 99.5 | 10 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.026 | 0.045 | 0.58 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.605 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
