Two sample MR report
Depressed affect || id:ebi-a-GCST006475 against Diabetic nephropathy || id:ebi-a-GCST90018832
Date: 27 November, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 53 | 1.694 | 2.183 | 0.441 |
| Weighted median | 53 | 1.315 | 0.640 | 0.040 |
| Inverse variance weighted | 53 | 0.842 | 0.447 | 0.059 |
| Simple mode | 53 | 1.583 | 1.538 | 0.308 |
| Weighted mode | 53 | 1.539 | 1.314 | 0.247 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 57.4 | 51 | 0.251 |
| Inverse variance weighted | 57.5 | 52 | 0.277 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.014 | 0.035 | 0.692 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.732 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
