Two sample MR report
Depressed affect || id:ebi-a-GCST006475 against Diabetic nephropathy || id:finn-b-DM_NEPHROPATHY
Date: 22 November, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 57 | 0.794 | 1.159 | 0.496 |
| Weighted median | 57 | 0.009 | 0.343 | 0.978 |
| Inverse variance weighted | 57 | 0.107 | 0.246 | 0.663 |
| Simple mode | 57 | -0.154 | 0.854 | 0.857 |
| Weighted mode | 57 | -0.124 | 0.854 | 0.885 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 58.2 | 55 | 0.360 |
| Inverse variance weighted | 58.5 | 56 | 0.382 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.011 | 0.019 | 0.547 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.838 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
