Two sample MR report
Depression || id:ebi-a-GCST90018613 against Diabetic nephropathy || id:ebi-a-GCST90018612
Date: 21 November, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 1.178 | 0.926 | 0.272 |
| Weighted median | 6 | 0.135 | 0.206 | 0.513 |
| Inverse variance weighted | 6 | 0.126 | 0.171 | 0.462 |
| Simple mode | 6 | 0.109 | 0.302 | 0.734 |
| Weighted mode | 6 | 0.106 | 0.293 | 0.733 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.338 | 4 | 0.987 |
| Inverse variance weighted | 1.674 | 5 | 0.892 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.281 | 0.243 | 0.312 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.94 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
