Two sample MR report
Diabetic nephropathy || id:ebi-a-GCST90018612 against Depression || id:ebi-a-GCST90018613
Date: 21 November, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | 0.062 | 0.171 | 0.742 |
| Weighted median | 5 | -0.006 | 0.060 | 0.916 |
| Inverse variance weighted | 5 | -0.019 | 0.049 | 0.700 |
| Simple mode | 5 | -0.002 | 0.083 | 0.986 |
| Weighted mode | 5 | 0.002 | 0.077 | 0.977 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.74 | 3 | 0.627 |
| Inverse variance weighted | 1.99 | 4 | 0.739 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.048 | 0.098 | 0.657 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.923 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
