Two sample MR report
Diabetic nephropathy || id:ebi-a-GCST90018832 against Depressed affect || id:ebi-a-GCST006475
Date: 21 November, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 11 | -0.004 | 0.007 | 0.558 |
| Weighted median | 11 | -0.001 | 0.004 | 0.768 |
| Inverse variance weighted | 11 | -0.006 | 0.004 | 0.122 |
| Simple mode | 11 | 0.002 | 0.006 | 0.757 |
| Weighted mode | 11 | 0.000 | 0.005 | 0.926 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 16.9 | 9 | 0.050 |
| Inverse variance weighted | 17.1 | 10 | 0.071 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.001 | 0.003 | 0.739 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.951 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
