Two sample MR report
Osteoarthritis (SPA correction) || id:ebi-a-GCST90013931 against Type 2 diabetes || id:ebi-a-GCST010118
Date: 25 November, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 19 | -0.031 | 0.086 | 0.719 |
| Weighted median | 19 | -0.061 | 0.041 | 0.130 |
| Inverse variance weighted | 19 | -0.052 | 0.045 | 0.246 |
| Simple mode | 19 | -0.045 | 0.071 | 0.533 |
| Weighted mode | 19 | -0.060 | 0.038 | 0.130 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 52.4 | 17 | 0 |
| Inverse variance weighted | 52.6 | 18 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.002 | 0.006 | 0.775 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.898 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
