Two sample MR report
Osteoarthritis of the hip (hospital diagnosed) || id:ebi-a-GCST005810 against Body mass index (BMI) || id:ukb-b-2303
Date: 28 November, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 16 | -0.010 | 0.012 | 0.403 |
| Weighted median | 16 | 0.008 | 0.005 | 0.108 |
| Inverse variance weighted | 16 | 0.005 | 0.004 | 0.212 |
| Simple mode | 16 | 0.009 | 0.010 | 0.338 |
| Weighted mode | 16 | 0.009 | 0.009 | 0.317 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 17.6 | 14 | 0.227 |
| Inverse variance weighted | 19.7 | 15 | 0.184 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.003 | 0.003 | 0.215 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.371 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
