Two sample MR report
Troponin I || id:prot-c-5441_67_3 against Serum creatinine levels || id:ebi-a-GCST90018979
Date: 22 November, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | 0.008 | 0.011 | 0.536 |
| Weighted median | 5 | 0.007 | 0.005 | 0.181 |
| Inverse variance weighted | 5 | 0.004 | 0.004 | 0.313 |
| Simple mode | 5 | 0.008 | 0.007 | 0.301 |
| Weighted mode | 5 | 0.007 | 0.007 | 0.333 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.37 | 3 | 0.338 |
| Inverse variance weighted | 3.53 | 4 | 0.473 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.001 | 0.003 | 0.729 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.003 | 0 | TRUE | 0.095 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
