

# Two sample MR report

---

## Frailty index || id:ebi-a-GCST90020053 against Femoral hernia || id:finn-b-K11_FEMHER

Date: **18 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|      b|    se|  pval|
|:-------------------------|----:|------:|-----:|-----:|
|MR Egger                  |   13| -1.514| 8.114| 0.855|
|Weighted median           |   13| -0.301| 1.046| 0.774|
|Inverse variance weighted |   13| -0.480| 0.784| 0.541|
|Simple mode               |   13| -0.117| 1.729| 0.947|
|Weighted mode             |   13| -0.061| 1.711| 0.972|

---

### Heterogeneity tests


|method                    |    Q| Q_df| Q_pval|
|:-------------------------|----:|----:|------:|
|MR Egger                  | 7.71|   11|  0.739|
|Inverse variance weighted | 7.73|   12|  0.806|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|    se| pval|
|---------------:|-----:|----:|
|           0.021| 0.166|  0.9|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |        0.869|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Frailty_index__idebiaGCST90020053_against_Femoral_hernia__idfinnbK11FEMHERchunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Frailty_index__idebiaGCST90020053_against_Femoral_hernia__idfinnbK11FEMHERchunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/Frailty_index__idebiaGCST90020053_against_Femoral_hernia__idfinnbK11FEMHERchunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Frailty_index__idebiaGCST90020053_against_Femoral_hernia__idfinnbK11FEMHERchunk8-1.png)
