

# Two sample MR report

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## RBC distribution width (RDW) against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.1401874| 0.2261199| 0.6466929|
|Weighted median           |    3| -0.1916210| 0.0972900| 0.0488860|
|Inverse variance weighted |    3| -0.1880817| 0.0932567| 0.0437147|
|Simple mode               |    3| -0.2179633| 0.1323530| 0.2413452|
|Weighted mode             |    3| -0.1695140| 0.1160897| 0.2816729|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0100737|    1| 0.9200522|
|Inverse variance weighted | 0.0641317|    2| 0.9684428|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0013183| 0.0056702| 0.8545675|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|           2e-07|              0|TRUE                     |    0.8716729|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RBC_distribution_width_RDW_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RBC_distribution_width_RDW_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RBC_distribution_width_RDW_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RBC_distribution_width_RDW_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
