

# Two sample MR report

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## Cytochrome c oxidase subunit 8A, mitochondrial against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    8| -0.0113334| 0.0081083| 0.2116831|
|Weighted median           |    8| -0.0115180| 0.0061424| 0.0607688|
|Inverse variance weighted |    8| -0.0130215| 0.0054991| 0.0178872|
|Simple mode               |    8| -0.0101938| 0.0115896| 0.4082738|
|Weighted mode             |    8| -0.0112987| 0.0060834| 0.1056315|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.805349|    6| 0.8328510|
|Inverse variance weighted | 2.885609|    7| 0.8953788|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0009065| 0.0031998| 0.7864663|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0160573|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Cytochrome_c_oxidase_subunit_8A_mitochondrial_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Cytochrome_c_oxidase_subunit_8A_mitochondrial_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Cytochrome_c_oxidase_subunit_8A_mitochondrial_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Cytochrome_c_oxidase_subunit_8A_mitochondrial_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
