

# Two sample MR report

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## MIG against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    9| 0.0136816| 0.0172057| 0.4526224|
|Weighted median           |    9| 0.0300492| 0.0115401| 0.0092174|
|Inverse variance weighted |    9| 0.0306411| 0.0084459| 0.0002857|
|Simple mode               |    9| 0.0343870| 0.0152649| 0.0543388|
|Weighted mode             |    9| 0.0300547| 0.0140708| 0.0651854|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 6.632990|    7| 0.4680656|
|Inverse variance weighted | 7.913015|    8| 0.4420129|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0052109| 0.0046058| 0.2951603|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003605|              0|TRUE                     |    0.2532705|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/MIG_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/MIG_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/MIG_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/MIG_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
