

# Two sample MR report

---

## Interleukin-15 receptor subunit alpha levels against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   10| -0.0010518| 0.0122285| 0.9335683|
|Weighted median           |   10|  0.0123428| 0.0080151| 0.1235738|
|Inverse variance weighted |   10|  0.0180921| 0.0080220| 0.0241131|
|Simple mode               |   10|  0.0124023| 0.0163246| 0.4668506|
|Weighted mode             |   10|  0.0133830| 0.0082778| 0.1403900|

---

### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  |  7.395404|    8| 0.4946330|
|Inverse variance weighted | 11.150562|    9| 0.2655297|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0045293| 0.0023373| 0.0886438|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0048205|              0|TRUE                     |            0|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Interleukin15_receptor_subunit_alpha_levels_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Interleukin15_receptor_subunit_alpha_levels_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/Interleukin15_receptor_subunit_alpha_levels_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Interleukin15_receptor_subunit_alpha_levels_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
