

# Two sample MR report

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## CD62L- myeloid Dendritic Cell %Dendritic Cell against Frailty index || id:ebi-a-GCST90020053

Date: **07 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.0107716| 0.0097229| 0.4674518|
|Weighted median           |    3| 0.0070475| 0.0050548| 0.1632509|
|Inverse variance weighted |    3| 0.0119673| 0.0043217| 0.0056213|
|Simple mode               |    3| 0.0065497| 0.0071292| 0.4552333|
|Weighted mode             |    3| 0.0177260| 0.0055581| 0.0858473|

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### Heterogeneity tests


|method                    |        Q| Q_df|   Q_pval|
|:-------------------------|--------:|----:|--------:|
|MR Egger                  | 1.651588|    1| 0.198743|
|Inverse variance weighted | 1.688661|    2| 0.429845|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0010858| 0.0072473| 0.9053233|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0447161|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CD62L_myeloid_Dendritic_Cell_Dendritic_Cell_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CD62L_myeloid_Dendritic_Cell_Dendritic_Cell_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CD62L_myeloid_Dendritic_Cell_Dendritic_Cell_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CD62L_myeloid_Dendritic_Cell_Dendritic_Cell_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
