

# Two sample MR report

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## (phylum: proteobacteria) at the forehead (sebaceous skin) against Frailty index || id:ebi-a-GCST90020053

Date: **07 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.0184289| 0.0928667| 0.8752865|
|Weighted median           |    3| -0.0058403| 0.0060301| 0.3327818|
|Inverse variance weighted |    3| -0.0102664| 0.0051487| 0.0461554|
|Simple mode               |    3| -0.0055863| 0.0076601| 0.5416763|
|Weighted mode             |    3| -0.0056271| 0.0067318| 0.4911659|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.301430|    1| 0.1292549|
|Inverse variance weighted | 2.319319|    2| 0.3135929|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0037504| 0.0425383| 0.9440176|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0196254|              0|TRUE                     |    0.0206229|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/phylum_proteobacteria_at_the_forehead_sebaceous_skin_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/phylum_proteobacteria_at_the_forehead_sebaceous_skin_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/phylum_proteobacteria_at_the_forehead_sebaceous_skin_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/phylum_proteobacteria_at_the_forehead_sebaceous_skin_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
