

# Two sample MR report

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## 1,2-dipalmitoyl-gpc (16:0/16:0) levels against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   13| 0.0804478| 0.0328937| 0.0324931|
|Weighted median           |   13| 0.0676255| 0.0120737| 0.0000000|
|Inverse variance weighted |   13| 0.0564176| 0.0137624| 0.0000414|
|Simple mode               |   13| 0.0589811| 0.0208341| 0.0151480|
|Weighted mode             |   13| 0.0668189| 0.0119981| 0.0001220|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 27.78075|   11| 0.0034972|
|Inverse variance weighted | 29.42507|   12| 0.0034056|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0034628| 0.0042916| 0.4368263|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0009846|              0|TRUE                     |    0.0055576|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/12dipalmitoylgpc_160160_levels_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/12dipalmitoylgpc_160160_levels_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/12dipalmitoylgpc_160160_levels_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/12dipalmitoylgpc_160160_levels_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
