

# Two sample MR report

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## 1-stearoyl-gpc (18:0) levels against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.0469163| 0.2091627| 0.8595277|
|Weighted median           |    3| 0.0700978| 0.0232022| 0.0025180|
|Inverse variance weighted |    3| 0.0796800| 0.0273655| 0.0035948|
|Simple mode               |    3| 0.0501187| 0.0320031| 0.2578283|
|Weighted mode             |    3| 0.0596206| 0.0283790| 0.1704430|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.694803|    1| 0.0302540|
|Inverse variance weighted | 4.813977|    2| 0.0900862|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0042452| 0.0266448| 0.8994165|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000132|              0|TRUE                     |    0.3128917|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/1stearoylgpc_180_levels_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/1stearoylgpc_180_levels_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/1stearoylgpc_180_levels_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/1stearoylgpc_180_levels_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
