

# Two sample MR report

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## 2,4-dienoyl-CoA reductase,mitochondrial levels against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    8| 0.0038043| 0.0061942| 0.5616458|
|Weighted median           |    8| 0.0057611| 0.0051965| 0.2675751|
|Inverse variance weighted |    8| 0.0080686| 0.0040488| 0.0462822|
|Simple mode               |    8| 0.0162292| 0.0087877| 0.1072676|
|Weighted mode             |    8| 0.0023222| 0.0066746| 0.7381370|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.192007|    6| 0.7843907|
|Inverse variance weighted | 4.019487|    7| 0.7775302|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0023953| 0.0026331| 0.3980699|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0024638|              0|TRUE                     |    0.0752519|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/24dienoylCoA_reductasemitochondrial_levels_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/24dienoylCoA_reductasemitochondrial_levels_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/24dienoylCoA_reductasemitochondrial_levels_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/24dienoylCoA_reductasemitochondrial_levels_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
