

# Two sample MR report

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## Palmitoylcarnitine levels (Metabolon platform) against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   17|  0.0272973| 0.0391245| 0.4960359|
|Weighted median           |   17|  0.0318968| 0.0156629| 0.0417045|
|Inverse variance weighted |   17|  0.0314603| 0.0138642| 0.0232576|
|Simple mode               |   17| -0.0048890| 0.0288989| 0.8677785|
|Weighted mode             |   17|  0.0352957| 0.0236432| 0.1549330|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 29.96278|   15| 0.0120564|
|Inverse variance weighted | 29.98889|   16| 0.0180599|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0004899| 0.0042851| 0.9104953|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000372|              0|TRUE                     |     0.089371|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Palmitoylcarnitine_levels_Metabolon_platform_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Palmitoylcarnitine_levels_Metabolon_platform_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Palmitoylcarnitine_levels_Metabolon_platform_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Palmitoylcarnitine_levels_Metabolon_platform_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
