

# Two sample MR report

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## PWY.5173..superpathway.of.acetyl.CoA.biosynthesis against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.1596929| 0.0477316| 0.0442017|
|Weighted median           |    5| -0.0302232| 0.0197739| 0.1264030|
|Inverse variance weighted |    5| -0.0447531| 0.0207503| 0.0310259|
|Simple mode               |    5| -0.0223325| 0.0238921| 0.4028492|
|Weighted mode             |    5| -0.0223325| 0.0211665| 0.3508986|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.006719|    3| 0.3905904|
|Inverse variance weighted | 9.331921|    4| 0.0533178|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0164614| 0.0065526| 0.0867707|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.57e-05|              0|TRUE                     |    0.6284835|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PWY5173superpathwayofacetylCoAbiosynthesis_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PWY5173superpathwayofacetylCoAbiosynthesis_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PWY5173superpathwayofacetylCoAbiosynthesis_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PWY5173superpathwayofacetylCoAbiosynthesis_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
