

# Two sample MR report

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## Steroidogenic acute regulatory protein, mitochondrial against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   13| 0.0415386| 0.0221826| 0.0879310|
|Weighted median           |   13| 0.0144958| 0.0106511| 0.1735217|
|Inverse variance weighted |   13| 0.0218905| 0.0092507| 0.0179636|
|Simple mode               |   13| 0.0077826| 0.0188096| 0.6863486|
|Weighted mode             |   13| 0.0093443| 0.0201736| 0.6515132|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 18.45971|   11| 0.0715087|
|Inverse variance weighted | 20.05485|   12| 0.0660555|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       -0.004661| 0.0047807| 0.3505362|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0009495|              0|TRUE                     |    0.0805108|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Steroidogenic_acute_regulatory_protein_mitochondrial_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Steroidogenic_acute_regulatory_protein_mitochondrial_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Steroidogenic_acute_regulatory_protein_mitochondrial_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Steroidogenic_acute_regulatory_protein_mitochondrial_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
