

# Two sample MR report

---

## Phosphatidylcholine (16:0_20:1) levels against Frailty index || id:ebi-a-GCST90020053

Date: **07 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    9| -0.3111703| 0.0836288| 0.0074477|
|Weighted median           |    9| -0.0246345| 0.0214994| 0.2518688|
|Inverse variance weighted |    9| -0.0452490| 0.0198163| 0.0224055|
|Simple mode               |    9| -0.0162688| 0.0353165| 0.6573085|
|Weighted mode             |    9| -0.0120206| 0.0343704| 0.7355652|

---

### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  |  6.098102|    7| 0.5283424|
|Inverse variance weighted | 16.492218|    8| 0.0358530|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0255478| 0.0079243| 0.0145726|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000128|              0|TRUE                     |    0.3618276|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylcholine_160201_levels_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylcholine_160201_levels_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylcholine_160201_levels_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylcholine_160201_levels_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
