

# Two sample MR report

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## Fibroblast growth factor 5 levels against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   21| 0.0162853| 0.0081034| 0.0588839|
|Weighted median           |   21| 0.0173311| 0.0067252| 0.0099646|
|Inverse variance weighted |   21| 0.0170989| 0.0058223| 0.0033160|
|Simple mode               |   21| 0.0053578| 0.0201792| 0.7933331|
|Weighted mode             |   21| 0.0173207| 0.0066154| 0.0164634|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 9.900324|   19| 0.9553618|
|Inverse variance weighted | 9.921165|   20| 0.9695790|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0002332| 0.0016152| 0.8867351|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.016909|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Fibroblast_growth_factor_5_levels_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Fibroblast_growth_factor_5_levels_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Fibroblast_growth_factor_5_levels_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Fibroblast_growth_factor_5_levels_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
