

# Two sample MR report

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## (asv: asv009) at the antecubital fossa (moist skin) against Frailty index || id:ebi-a-GCST90020053

Date: **07 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5|  0.0003193| 0.0120195| 0.9804752|
|Weighted median           |    5| -0.0071546| 0.0041186| 0.0823606|
|Inverse variance weighted |    5| -0.0062419| 0.0030243| 0.0390239|
|Simple mode               |    5| -0.0078621| 0.0054723| 0.2241615|
|Weighted mode             |    5| -0.0072982| 0.0052602| 0.2375981|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.295248|    3| 0.3483046|
|Inverse variance weighted | 3.647015|    4| 0.4558791|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.0042126| 0.007444| 0.6110226|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0513326|              0|TRUE                     |    0.0001535|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/asv_asv009_at_the_antecubital_fossa_moist_skin_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/asv_asv009_at_the_antecubital_fossa_moist_skin_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/asv_asv009_at_the_antecubital_fossa_moist_skin_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/asv_asv009_at_the_antecubital_fossa_moist_skin_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
