

# Two sample MR report

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## GLUCONEO.PWY..gluconeogenesis.I against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.0005023| 0.0578214| 0.9938575|
|Weighted median           |    4| 0.0476752| 0.0255453| 0.0619997|
|Inverse variance weighted |    4| 0.0536483| 0.0205135| 0.0089156|
|Simple mode               |    4| 0.0807902| 0.0364119| 0.1131712|
|Weighted mode             |    4| 0.0337161| 0.0307368| 0.3528312|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.5689097|    2| 0.7524243|
|Inverse variance weighted | 1.5353704|    3| 0.6741313|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0074377| 0.0075657| 0.4292147|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.47e-05|              0|TRUE                     |    0.6310206|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/GLUCONEOPWYgluconeogenesisI_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/GLUCONEOPWYgluconeogenesisI_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/GLUCONEOPWYgluconeogenesisI_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/GLUCONEOPWYgluconeogenesisI_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
