

# Two sample MR report

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## PWY.7456..mannan.degradation against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.0070894| 0.0917844| 0.9454648|
|Weighted median           |    4| -0.0712419| 0.0248539| 0.0041514|
|Inverse variance weighted |    4| -0.0791084| 0.0188510| 0.0000271|
|Simple mode               |    4| -0.0668901| 0.0319216| 0.1271145|
|Weighted mode             |    4| -0.0679013| 0.0319962| 0.1239271|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.671603|    2| 0.4335269|
|Inverse variance weighted | 2.314401|    3| 0.5097677|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0110824| 0.0138229| 0.5068201|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.24e-05|              0|TRUE                     |    0.6503109|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PWY7456mannandegradation_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PWY7456mannandegradation_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PWY7456mannandegradation_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PWY7456mannandegradation_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
