

# Two sample MR report

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## genus.Lachnoclostridium.id.11308 against Frailty index || id:ebi-a-GCST90020053

Date: **05 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0964230| 0.1490439| 0.5529205|
|Weighted median           |    6| -0.0558906| 0.0363367| 0.1240166|
|Inverse variance weighted |    6| -0.0567291| 0.0274496| 0.0387657|
|Simple mode               |    6| -0.0905845| 0.0563883| 0.1690862|
|Weighted mode             |    6| -0.0753505| 0.0548530| 0.2279309|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.137177|    4| 0.2735097|
|Inverse variance weighted | 5.232226|    5| 0.3882015|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0024856| 0.0091366| 0.7990513|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|         9.6e-06|              0|TRUE                     |    0.6968467|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/genusLachnoclostridiumid11308_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/genusLachnoclostridiumid11308_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/genusLachnoclostridiumid11308_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/genusLachnoclostridiumid11308_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
