

# Two sample MR report

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## CD11c+ HLA DR++ monocyte Absolute Count against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.0198873| 0.0165832| 0.4424815|
|Weighted median           |    3| 0.0231115| 0.0128831| 0.0728239|
|Inverse variance weighted |    3| 0.0263890| 0.0105363| 0.0122592|
|Simple mode               |    3| 0.0251293| 0.0181463| 0.3003581|
|Weighted mode             |    3| 0.0216772| 0.0126235| 0.2280779|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.138433|    1| 0.2859836|
|Inverse variance weighted | 1.462239|    2| 0.4813697|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0039801| 0.0074628| 0.6880895|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001594|              0|TRUE                     |    0.4927129|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CD11c_HLA_DR_monocyte_Absolute_Count_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CD11c_HLA_DR_monocyte_Absolute_Count_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CD11c_HLA_DR_monocyte_Absolute_Count_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CD11c_HLA_DR_monocyte_Absolute_Count_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
