

# Two sample MR report

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## mitochondrial CNV against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   49| -0.1026418| 0.0683787| 0.1400241|
|Weighted median           |   49| -0.0774741| 0.0400977| 0.0533431|
|Inverse variance weighted |   49| -0.0737902| 0.0283830| 0.0093277|
|Simple mode               |   49| -0.0611050| 0.0648327| 0.3506550|
|Weighted mode             |   49| -0.0611050| 0.0524367| 0.2496524|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 52.70731|   47| 0.2628589|
|Inverse variance weighted | 52.94936|   48| 0.2890034|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0007197| 0.0015491| 0.6443754|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.3499172|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/mitochondrial_CNV_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/mitochondrial_CNV_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/mitochondrial_CNV_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/mitochondrial_CNV_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
