

# Two sample MR report

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## GLUCOSE1PMETAB.PWY..glucose.and.glucose.1.phosphate.degradation against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.0173179| 0.1144946| 0.8936529|
|Weighted median           |    4| 0.0441828| 0.0193654| 0.0225168|
|Inverse variance weighted |    4| 0.0390027| 0.0150692| 0.0096469|
|Simple mode               |    4| 0.0548032| 0.0288385| 0.1535784|
|Weighted mode             |    4| 0.0536725| 0.0283221| 0.1543791|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.595496|    2| 0.2731462|
|Inverse variance weighted | 2.643118|    3| 0.4499805|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0030145| 0.0157364| 0.8657718|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        1.96e-05|              0|TRUE                     |    0.6689051|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/GLUCOSE1PMETABPWYglucoseandglucose1phosphatedegradation_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/GLUCOSE1PMETABPWYglucoseandglucose1phosphatedegradation_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/GLUCOSE1PMETABPWYglucoseandglucose1phosphatedegradation_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/GLUCOSE1PMETABPWYglucoseandglucose1phosphatedegradation_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
