

# Two sample MR report

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## PWY0.1296..purine.ribonucleosides.degradation against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5|  0.0476313| 0.0723934| 0.5575508|
|Weighted median           |    5| -0.0364877| 0.0258054| 0.1573736|
|Inverse variance weighted |    5| -0.0450442| 0.0200818| 0.0248942|
|Simple mode               |    5| -0.0374554| 0.0385113| 0.3858333|
|Weighted mode             |    5| -0.0334199| 0.0352703| 0.3970192|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.863887|    3| 0.4130906|
|Inverse variance weighted | 4.619697|    4| 0.3285895|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0098939| 0.0074667| 0.2770311|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.01e-05|              0|TRUE                     |    0.5965296|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PWY01296purineribonucleosidesdegradation_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PWY01296purineribonucleosidesdegradation_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PWY01296purineribonucleosidesdegradation_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PWY01296purineribonucleosidesdegradation_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
