

# Two sample MR report

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## POLYAMINSYN3.PWY..superpathway.of.polyamine.biosynthesis.II against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6|  0.0239712| 0.0497015| 0.6547943|
|Weighted median           |    6| -0.0226146| 0.0167105| 0.1759547|
|Inverse variance weighted |    6| -0.0281895| 0.0132872| 0.0338749|
|Simple mode               |    6| -0.0196175| 0.0236751| 0.4450634|
|Weighted mode             |    6| -0.0167662| 0.0239733| 0.5155112|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.010508|    4| 0.9081985|
|Inverse variance weighted | 2.196694|    5| 0.8213133|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0077953| 0.0071574| 0.3373216|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.09e-05|              0|TRUE                     |    0.5907028|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/POLYAMINSYN3PWYsuperpathwayofpolyaminebiosynthesisII_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/POLYAMINSYN3PWYsuperpathwayofpolyaminebiosynthesisII_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/POLYAMINSYN3PWYsuperpathwayofpolyaminebiosynthesisII_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/POLYAMINSYN3PWYsuperpathwayofpolyaminebiosynthesisII_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
