

# Two sample MR report

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## Sleep apnoea || id:ukb-d-G6_SLEEPAPNO against Frailty index || id:ebi-a-GCST90020053

Date: **07 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|    b|    se|  pval|
|:-------------------------|----:|----:|-----:|-----:|
|MR Egger                  |   15| 2.69| 2.078| 0.219|
|Weighted median           |   15| 2.26| 1.395| 0.105|
|Inverse variance weighted |   15| 1.92| 0.994| 0.054|
|Simple mode               |   15| 2.98| 2.629| 0.277|
|Weighted mode             |   15| 2.88| 2.304| 0.232|

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### Heterogeneity tests


|method                    |    Q| Q_df| Q_pval|
|:-------------------------|----:|----:|------:|
|MR Egger                  | 14.6|   13|  0.334|
|Inverse variance weighted | 14.8|   14|  0.393|

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### Test for directional horizontal pleiotropy


| egger_intercept|    se|  pval|
|---------------:|-----:|-----:|
|          -0.001| 0.003| 0.679|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |        0.944|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Sleep_apnoea__idukbdG6SLEEPAPNO_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Sleep_apnoea__idukbdG6SLEEPAPNO_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Sleep_apnoea__idukbdG6SLEEPAPNO_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Sleep_apnoea__idukbdG6SLEEPAPNO_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
