

# Two sample MR report

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## Lysine against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   14| 0.2528291| 0.6858180| 0.7188079|
|Weighted median           |   14| 0.3521619| 0.1884769| 0.0616978|
|Inverse variance weighted |   14| 0.3017517| 0.1342540| 0.0246006|
|Simple mode               |   14| 0.4228934| 0.3019645| 0.1847853|
|Weighted mode             |   14| 0.3713497| 0.2340317| 0.1365844|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 14.13880|   12| 0.2919330|
|Inverse variance weighted | 14.14505|   13| 0.3637087|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|       0.0004783| 0.0065641| 0.943116|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002192|              0|TRUE                     |    0.2147346|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Lysine_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Lysine_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Lysine_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Lysine_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
