

# Two sample MR report

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## genus.Ruminiclostridium9.id.11357 against Frailty index || id:ebi-a-GCST90020053

Date: **05 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    8|  0.0598666| 0.1177286| 0.6292439|
|Weighted median           |    8| -0.0378826| 0.0288882| 0.1897380|
|Inverse variance weighted |    8| -0.0460725| 0.0222353| 0.0382616|
|Simple mode               |    8| -0.0247948| 0.0416783| 0.5706258|
|Weighted mode             |    8| -0.0197271| 0.0421357| 0.6538833|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.675533|    6| 0.5860492|
|Inverse variance weighted | 5.515234|    7| 0.5973470|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0075156| 0.0082017| 0.3948205|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        1.47e-05|              0|TRUE                     |    0.6414195|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/genusRuminiclostridium9id11357_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/genusRuminiclostridium9id11357_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/genusRuminiclostridium9id11357_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/genusRuminiclostridium9id11357_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
