

# Two sample MR report

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## X-12100 levels against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.0786805| 0.1135632| 0.5600515|
|Weighted median           |    4| 0.0533711| 0.0274257| 0.0516520|
|Inverse variance weighted |    4| 0.0594741| 0.0226764| 0.0087228|
|Simple mode               |    4| 0.0265263| 0.0450285| 0.5972135|
|Weighted mode             |    4| 0.0218935| 0.0383843| 0.6083438|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.625387|    2| 0.1632139|
|Inverse variance weighted | 3.680482|    3| 0.2980975|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0021712| 0.0124541| 0.8776499|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        7.67e-05|              0|TRUE                     |    0.4413669|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/X12100_levels_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/X12100_levels_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/X12100_levels_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/X12100_levels_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
