

# Two sample MR report

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## PWY.7209..superpathway.of.pyrimidine.ribonucleosides.degradation against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   10| -0.0382300| 0.0386362| 0.3514045|
|Weighted median           |   10| -0.0231874| 0.0145066| 0.1099519|
|Inverse variance weighted |   10| -0.0233699| 0.0111144| 0.0354952|
|Simple mode               |   10| -0.0167313| 0.0231763| 0.4886769|
|Weighted mode             |   10| -0.0176845| 0.0226233| 0.4544643|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 9.205642|    8| 0.3252465|
|Inverse variance weighted | 9.392955|    9| 0.4018195|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0019505| 0.0048343| 0.6971774|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.47e-05|              0|TRUE                     |    0.4747788|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PWY7209superpathwayofpyrimidineribonucleosidesdegradation_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PWY7209superpathwayofpyrimidineribonucleosidesdegradation_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PWY7209superpathwayofpyrimidineribonucleosidesdegradation_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PWY7209superpathwayofpyrimidineribonucleosidesdegradation_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
