

# Two sample MR report

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## Alpha-ketoglutarate to kynurenine ratio against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.1460779| 0.0891405| 0.3488067|
|Weighted median           |    3| -0.0490036| 0.0251868| 0.0517015|
|Inverse variance weighted |    3| -0.0474608| 0.0210393| 0.0240825|
|Simple mode               |    3| -0.0355801| 0.0332918| 0.3970888|
|Weighted mode             |    3| -0.0611434| 0.0295188| 0.1741326|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1614407|    1| 0.6878335|
|Inverse variance weighted | 1.4575711|    2| 0.4824946|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0104722| 0.0091984| 0.4588331|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|         7.4e-05|              0|TRUE                     |    0.4463304|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Alphaketoglutarate_to_kynurenine_ratio_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Alphaketoglutarate_to_kynurenine_ratio_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Alphaketoglutarate_to_kynurenine_ratio_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Alphaketoglutarate_to_kynurenine_ratio_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
