

# Two sample MR report

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## NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   17| 0.0092348| 0.0057650| 0.1300303|
|Weighted median           |   17| 0.0084746| 0.0038362| 0.0271675|
|Inverse variance weighted |   17| 0.0081960| 0.0040046| 0.0406929|
|Simple mode               |   17| 0.0004400| 0.0147135| 0.9765149|
|Weighted mode             |   17| 0.0081213| 0.0039912| 0.0587891|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 21.69418|   15| 0.1160773|
|Inverse variance weighted | 21.79049|   16| 0.1500860|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.0004746| 0.001839| 0.7998661|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.1243148|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/NADH_dehydrogenase_ubiquinone_ironsulfur_protein_4_mitochondrial_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/NADH_dehydrogenase_ubiquinone_ironsulfur_protein_4_mitochondrial_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/NADH_dehydrogenase_ubiquinone_ironsulfur_protein_4_mitochondrial_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/NADH_dehydrogenase_ubiquinone_ironsulfur_protein_4_mitochondrial_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
