

# Two sample MR report

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## Plasmacytoid Dendritic Cell %Dendritic Cell against Frailty index || id:ebi-a-GCST90020053

Date: **07 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7| -0.0336379| 0.0120385| 0.0382551|
|Weighted median           |    7| -0.0207346| 0.0077673| 0.0075974|
|Inverse variance weighted |    7| -0.0157836| 0.0068131| 0.0205230|
|Simple mode               |    7|  0.0028234| 0.0174901| 0.8770547|
|Weighted mode             |    7| -0.0240501| 0.0085966| 0.0312614|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.074351|    5| 0.9563487|
|Inverse variance weighted | 4.310414|    6| 0.6347476|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0062143| 0.0034545| 0.1319433|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0135931|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Plasmacytoid_Dendritic_Cell_Dendritic_Cell_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Plasmacytoid_Dendritic_Cell_Dendritic_Cell_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Plasmacytoid_Dendritic_Cell_Dendritic_Cell_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Plasmacytoid_Dendritic_Cell_Dendritic_Cell_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
