

# Two sample MR report

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## PWY.5101..L.isoleucine.biosynthesis.II against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0210407| 0.0796158| 0.8046234|
|Weighted median           |    6| -0.0560001| 0.0227689| 0.0139131|
|Inverse variance weighted |    6| -0.0494456| 0.0168490| 0.0033395|
|Simple mode               |    6| -0.0748816| 0.0336402| 0.0765532|
|Weighted mode             |    6| -0.0725313| 0.0353168| 0.0951890|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.383136|    4| 0.3566303|
|Inverse variance weighted | 4.529814|    5| 0.4759043|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0027928| 0.0076334| 0.7329936|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.05e-05|              0|TRUE                     |    0.5938419|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PWY5101LisoleucinebiosynthesisII_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PWY5101LisoleucinebiosynthesisII_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PWY5101LisoleucinebiosynthesisII_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PWY5101LisoleucinebiosynthesisII_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
