

# Two sample MR report

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## 39S ribosomal protein L32, mitochondrial against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   10| 0.0171017| 0.0244786| 0.5045769|
|Weighted median           |   10| 0.0148652| 0.0119880| 0.2149729|
|Inverse variance weighted |   10| 0.0187746| 0.0089049| 0.0350014|
|Simple mode               |   10| 0.0141822| 0.0180719| 0.4527537|
|Weighted mode             |   10| 0.0144017| 0.0181737| 0.4484836|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.884262|    8| 0.8674118|
|Inverse variance weighted | 3.889645|    9| 0.9185244|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|        0.000282| 0.0038431| 0.9433148|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004986|              0|TRUE                     |    0.2043615|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/39S_ribosomal_protein_L32_mitochondrial_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/39S_ribosomal_protein_L32_mitochondrial_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/39S_ribosomal_protein_L32_mitochondrial_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/39S_ribosomal_protein_L32_mitochondrial_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
