

# Two sample MR report

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## mitochondrial CNV against Frailty index || id:ebi-a-GCST90020053

Date: **06 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   67| -0.0918894| 0.0746379| 0.2227086|
|Weighted median           |   67| -0.0766719| 0.0393206| 0.0511858|
|Inverse variance weighted |   67| -0.0758941| 0.0315209| 0.0160517|
|Simple mode               |   67| -0.0613593| 0.0700050| 0.3839382|
|Weighted mode             |   67| -0.0613593| 0.0521063| 0.2431934|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 104.9425|   65| 0.0012496|
|Inverse variance weighted | 105.0331|   66| 0.0015971|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|    pval|
|---------------:|---------:|-------:|
|       0.0003723| 0.0015724| 0.81356|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.3849866|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/mitochondrial_CNV_against_Frailty_index__idebiaGCST90020053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/mitochondrial_CNV_against_Frailty_index__idebiaGCST90020053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/mitochondrial_CNV_against_Frailty_index__idebiaGCST90020053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/mitochondrial_CNV_against_Frailty_index__idebiaGCST90020053chunk8-1.png)
