Two sample MR report
Diagnoses - main ICD10: G47.3 Sleep apnoea || id:ukb-b-16781 against Frailty index || id:ebi-a-GCST90020053
Date: 07 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | -10.85 | 16.52 | 0.579 |
| Weighted median | 4 | 6.73 | 3.03 | 0.026 |
| Inverse variance weighted | 4 | 6.79 | 2.38 | 0.004 |
| Simple mode | 4 | 6.49 | 4.22 | 0.221 |
| Weighted mode | 4 | 6.32 | 3.71 | 0.187 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.698 | 2 | 0.705 |
| Inverse variance weighted | 1.862 | 3 | 0.601 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.014 | 0.013 | 0.393 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.983 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
