Two sample MR report
Diagnoses - secondary ICD10: G47.3 Sleep apnoea || id:ukb-b-7853 against Frailty index || id:ebi-a-GCST90020053
Date: 07 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 9.12 | 104.39 | 0.938 |
| Weighted median | 4 | 1.56 | 3.60 | 0.664 |
| Inverse variance weighted | 4 | 1.91 | 3.32 | 0.565 |
| Simple mode | 4 | 6.81 | 6.42 | 0.366 |
| Weighted mode | 4 | -3.18 | 6.41 | 0.653 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.50 | 2 | 0.174 |
| Inverse variance weighted | 3.51 | 3 | 0.320 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.004 | 0.061 | 0.951 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.976 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
