Two sample MR report
Non-cancer illness code self-reported: sleep apnoea || id:ukb-a-69 against Frailty index || id:ebi-a-GCST90020053
Date: 07 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 13 | -5.976 | 2.97 | 0.069 |
| Weighted median | 13 | -0.181 | 1.94 | 0.926 |
| Inverse variance weighted | 13 | -1.586 | 1.58 | 0.315 |
| Simple mode | 13 | 0.329 | 3.31 | 0.922 |
| Weighted mode | 13 | 0.252 | 3.37 | 0.942 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 12.7 | 11 | 0.312 |
| Inverse variance weighted | 16.1 | 12 | 0.188 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.005 | 0.003 | 0.117 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.949 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
