Two sample MR report


Non-cancer illness code, self-reported: sleep apnoea || id:ukb-b-9155 against Frailty index || id:ebi-a-GCST90020053

Date: 07 January, 2026


Results from two sample MR:

method nsnp b se pval
Inverse variance weighted 2 -0.259 4.22 0.951

Heterogeneity tests

method Q Q_df Q_pval
Inverse variance weighted 0 1 0.983

Test for directional horizontal pleiotropy

egger_intercept se pval
NA NA NA

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0 0 TRUE 0.981

Note - R^2 values are approximate


Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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