Two sample MR report
Sleep apnoea || id:finn-b-G6_SLEEPAPNO against Frailty index || id:ebi-a-GCST90020053
Date: 07 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 28 | -0.034 | 0.053 | 0.520 |
| Weighted median | 28 | 0.044 | 0.016 | 0.006 |
| Inverse variance weighted | 28 | 0.033 | 0.014 | 0.018 |
| Simple mode | 28 | 0.059 | 0.033 | 0.080 |
| Weighted mode | 28 | 0.052 | 0.026 | 0.055 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 49.1 | 26 | 0.004 |
| Inverse variance weighted | 52.4 | 27 | 0.002 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.006 | 0.004 | 0.195 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.94 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
