Two sample MR report
Sleep apnoea || id:ukb-d-G6_SLEEPAPNO against Frailty index || id:ebi-a-GCST90020053
Date: 07 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 15 | 2.69 | 2.078 | 0.219 |
| Weighted median | 15 | 2.26 | 1.395 | 0.105 |
| Inverse variance weighted | 15 | 1.92 | 0.994 | 0.054 |
| Simple mode | 15 | 2.98 | 2.629 | 0.277 |
| Weighted mode | 15 | 2.88 | 2.304 | 0.232 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 14.6 | 13 | 0.334 |
| Inverse variance weighted | 14.8 | 14 | 0.393 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.001 | 0.003 | 0.679 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.944 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
