Two sample MR report
Sleep apnoea, including avohilmo || id:finn-b-G6_SLEEPAPNO_INCLAVO against Frailty index || id:ebi-a-GCST90020053
Date: 07 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 26 | -0.004 | 0.056 | 0.948 |
| Weighted median | 26 | 0.047 | 0.016 | 0.004 |
| Inverse variance weighted | 26 | 0.040 | 0.014 | 0.005 |
| Simple mode | 26 | 0.065 | 0.031 | 0.047 |
| Weighted mode | 26 | 0.058 | 0.024 | 0.026 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 45.5 | 24 | 0.005 |
| Inverse variance weighted | 46.8 | 25 | 0.005 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.004 | 0.004 | 0.426 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.941 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
