Two sample MR report
MIG against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 9 | 0.0136816 | 0.0172057 | 0.4526224 |
| Weighted median | 9 | 0.0300492 | 0.0115401 | 0.0092174 |
| Inverse variance weighted | 9 | 0.0306411 | 0.0084459 | 0.0002857 |
| Simple mode | 9 | 0.0343870 | 0.0152649 | 0.0543388 |
| Weighted mode | 9 | 0.0300547 | 0.0140708 | 0.0651854 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 6.632990 | 7 | 0.4680656 |
| Inverse variance weighted | 7.913015 | 8 | 0.4420129 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0052109 | 0.0046058 | 0.2951603 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003605 | 0 | TRUE | 0.2532705 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
