Two sample MR report
Fibroblast growth factor 5 levels against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 21 | 0.0162853 | 0.0081034 | 0.0588839 |
| Weighted median | 21 | 0.0173311 | 0.0067252 | 0.0099646 |
| Inverse variance weighted | 21 | 0.0170989 | 0.0058223 | 0.0033160 |
| Simple mode | 21 | 0.0053578 | 0.0201792 | 0.7933331 |
| Weighted mode | 21 | 0.0173207 | 0.0066154 | 0.0164634 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 9.900324 | 19 | 0.9553618 |
| Inverse variance weighted | 9.921165 | 20 | 0.9695790 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0002332 | 0.0016152 | 0.8867351 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.016909 | 0 | TRUE | 0 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
