Two sample MR report
Interleukin-15 receptor subunit alpha levels against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | -0.0010518 | 0.0122285 | 0.9335683 |
| Weighted median | 10 | 0.0123428 | 0.0080151 | 0.1235738 |
| Inverse variance weighted | 10 | 0.0180921 | 0.0080220 | 0.0241131 |
| Simple mode | 10 | 0.0124023 | 0.0163246 | 0.4668506 |
| Weighted mode | 10 | 0.0133830 | 0.0082778 | 0.1403900 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 7.395404 | 8 | 0.4946330 |
| Inverse variance weighted | 11.150562 | 9 | 0.2655297 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0045293 | 0.0023373 | 0.0886438 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0048205 | 0 | TRUE | 0 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
