Two sample MR report
genus.Lachnoclostridium.id.11308 against Frailty index || id:ebi-a-GCST90020053
Date: 05 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.0964230 | 0.1490439 | 0.5529205 |
| Weighted median | 6 | -0.0558906 | 0.0346362 | 0.1066038 |
| Inverse variance weighted | 6 | -0.0567291 | 0.0274496 | 0.0387657 |
| Simple mode | 6 | -0.0905845 | 0.0559409 | 0.1663104 |
| Weighted mode | 6 | -0.0753505 | 0.0536644 | 0.2192507 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 5.137177 | 4 | 0.2735097 |
| Inverse variance weighted | 5.232226 | 5 | 0.3882015 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0024856 | 0.0091366 | 0.7990513 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 9.6e-06 | 0 | TRUE | 0.6968467 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
