Two sample MR report
genus.Ruminiclostridium9.id.11357 against Frailty index || id:ebi-a-GCST90020053
Date: 05 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | 0.0598666 | 0.1177286 | 0.6292439 |
| Weighted median | 8 | -0.0378826 | 0.0288433 | 0.1890502 |
| Inverse variance weighted | 8 | -0.0460725 | 0.0222353 | 0.0382616 |
| Simple mode | 8 | -0.0247948 | 0.0460392 | 0.6068847 |
| Weighted mode | 8 | -0.0197271 | 0.0432316 | 0.6619863 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.675533 | 6 | 0.5860492 |
| Inverse variance weighted | 5.515234 | 7 | 0.5973470 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0075156 | 0.0082017 | 0.3948205 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 1.47e-05 | 0 | TRUE | 0.6414195 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
