Two sample MR report
GLUCONEO.PWY..gluconeogenesis.I against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 0.0005023 | 0.0578214 | 0.9938575 |
| Weighted median | 4 | 0.0476752 | 0.0255453 | 0.0619997 |
| Inverse variance weighted | 4 | 0.0536483 | 0.0205135 | 0.0089156 |
| Simple mode | 4 | 0.0807902 | 0.0364119 | 0.1131712 |
| Weighted mode | 4 | 0.0337161 | 0.0307368 | 0.3528312 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.5689097 | 2 | 0.7524243 |
| Inverse variance weighted | 1.5353704 | 3 | 0.6741313 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0074377 | 0.0075657 | 0.4292147 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 2.47e-05 | 0 | TRUE | 0.6310206 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
