Two sample MR report
POLYAMINSYN3.PWY..superpathway.of.polyamine.biosynthesis.II against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.0239712 | 0.0497015 | 0.6547943 |
| Weighted median | 6 | -0.0226146 | 0.0167105 | 0.1759547 |
| Inverse variance weighted | 6 | -0.0281895 | 0.0132872 | 0.0338749 |
| Simple mode | 6 | -0.0196175 | 0.0236751 | 0.4450634 |
| Weighted mode | 6 | -0.0167662 | 0.0239733 | 0.5155112 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.010508 | 4 | 0.9081985 |
| Inverse variance weighted | 2.196694 | 5 | 0.8213133 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0077953 | 0.0071574 | 0.3373216 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 3.09e-05 | 0 | TRUE | 0.5907028 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
