Two sample MR report
PWY0.1296..purine.ribonucleosides.degradation against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | 0.0476313 | 0.0723934 | 0.5575508 |
| Weighted median | 5 | -0.0364877 | 0.0258054 | 0.1573736 |
| Inverse variance weighted | 5 | -0.0450442 | 0.0200818 | 0.0248942 |
| Simple mode | 5 | -0.0374554 | 0.0385113 | 0.3858333 |
| Weighted mode | 5 | -0.0334199 | 0.0352703 | 0.3970192 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.863887 | 3 | 0.4130906 |
| Inverse variance weighted | 4.619697 | 4 | 0.3285895 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0098939 | 0.0074667 | 0.2770311 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 3.01e-05 | 0 | TRUE | 0.5965296 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
