Two sample MR report
PWY.5101..L.isoleucine.biosynthesis.II against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.0210407 | 0.0796158 | 0.8046234 |
| Weighted median | 6 | -0.0560001 | 0.0227689 | 0.0139131 |
| Inverse variance weighted | 6 | -0.0494456 | 0.0168490 | 0.0033395 |
| Simple mode | 6 | -0.0748816 | 0.0336402 | 0.0765532 |
| Weighted mode | 6 | -0.0725313 | 0.0353168 | 0.0951890 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.383136 | 4 | 0.3566303 |
| Inverse variance weighted | 4.529814 | 5 | 0.4759043 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0027928 | 0.0076334 | 0.7329936 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 3.05e-05 | 0 | TRUE | 0.5938419 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
