Two sample MR report
PWY.5173..superpathway.of.acetyl.CoA.biosynthesis against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.1596929 | 0.0477316 | 0.0442017 |
| Weighted median | 5 | -0.0302232 | 0.0197739 | 0.1264030 |
| Inverse variance weighted | 5 | -0.0447531 | 0.0207503 | 0.0310259 |
| Simple mode | 5 | -0.0223325 | 0.0238921 | 0.4028492 |
| Weighted mode | 5 | -0.0223325 | 0.0211665 | 0.3508986 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.006719 | 3 | 0.3905904 |
| Inverse variance weighted | 9.331921 | 4 | 0.0533178 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0164614 | 0.0065526 | 0.0867707 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 2.57e-05 | 0 | TRUE | 0.6284835 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
