Two sample MR report
PWY.7209..superpathway.of.pyrimidine.ribonucleosides.degradation against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | -0.0382300 | 0.0386362 | 0.3514045 |
| Weighted median | 10 | -0.0231874 | 0.0145066 | 0.1099519 |
| Inverse variance weighted | 10 | -0.0233699 | 0.0111144 | 0.0354952 |
| Simple mode | 10 | -0.0167313 | 0.0231763 | 0.4886769 |
| Weighted mode | 10 | -0.0176845 | 0.0226233 | 0.4544643 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 9.205642 | 8 | 0.3252465 |
| Inverse variance weighted | 9.392955 | 9 | 0.4018195 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0019505 | 0.0048343 | 0.6971774 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.47e-05 | 0 | TRUE | 0.4747788 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
