Two sample MR report
PWY.7456..mannan.degradation against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | -0.0070894 | 0.0917844 | 0.9454648 |
| Weighted median | 4 | -0.0712419 | 0.0248539 | 0.0041514 |
| Inverse variance weighted | 4 | -0.0791084 | 0.0188510 | 0.0000271 |
| Simple mode | 4 | -0.0668901 | 0.0319216 | 0.1271145 |
| Weighted mode | 4 | -0.0679013 | 0.0319962 | 0.1239271 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.671603 | 2 | 0.4335269 |
| Inverse variance weighted | 2.314401 | 3 | 0.5097677 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0110824 | 0.0138229 | 0.5068201 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 2.24e-05 | 0 | TRUE | 0.6503109 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
