Two sample MR report
Phosphatidylcholine (16:0_20:1) levels against Frailty index || id:ebi-a-GCST90020053
Date: 07 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 9 | -0.3111703 | 0.0836288 | 0.0074477 |
| Weighted median | 9 | -0.0246345 | 0.0214994 | 0.2518688 |
| Inverse variance weighted | 9 | -0.0452490 | 0.0198163 | 0.0224055 |
| Simple mode | 9 | -0.0162688 | 0.0353165 | 0.6573085 |
| Weighted mode | 9 | -0.0120206 | 0.0343704 | 0.7355652 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 6.098102 | 7 | 0.5283424 |
| Inverse variance weighted | 16.492218 | 8 | 0.0358530 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0255478 | 0.0079243 | 0.0145726 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000128 | 0 | TRUE | 0.3618276 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
