Two sample MR report
Lysine against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 14 | 0.2528291 | 0.6858180 | 0.7188079 |
| Weighted median | 14 | 0.3521619 | 0.1884769 | 0.0616978 |
| Inverse variance weighted | 14 | 0.3017517 | 0.1342540 | 0.0246006 |
| Simple mode | 14 | 0.4228934 | 0.3019645 | 0.1847853 |
| Weighted mode | 14 | 0.3713497 | 0.2340317 | 0.1365844 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 14.13880 | 12 | 0.2919330 |
| Inverse variance weighted | 14.14505 | 13 | 0.3637087 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0004783 | 0.0065641 | 0.943116 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002192 | 0 | TRUE | 0.2147346 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
