Two sample MR report
2,4-dienoyl-CoA reductase,mitochondrial levels against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | 0.0038043 | 0.0061942 | 0.5616458 |
| Weighted median | 8 | 0.0057611 | 0.0051965 | 0.2675751 |
| Inverse variance weighted | 8 | 0.0080686 | 0.0040488 | 0.0462822 |
| Simple mode | 8 | 0.0162292 | 0.0087877 | 0.1072676 |
| Weighted mode | 8 | 0.0023222 | 0.0066746 | 0.7381370 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.192007 | 6 | 0.7843907 |
| Inverse variance weighted | 4.019487 | 7 | 0.7775302 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0023953 | 0.0026331 | 0.3980699 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0024638 | 0 | TRUE | 0.0752519 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
