Two sample MR report
mitochondrial CNV against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 67 | -0.0918894 | 0.0746379 | 0.2227086 |
| Weighted median | 67 | -0.0766719 | 0.0393206 | 0.0511858 |
| Inverse variance weighted | 67 | -0.0758941 | 0.0315209 | 0.0160517 |
| Simple mode | 67 | -0.0613593 | 0.0700050 | 0.3839382 |
| Weighted mode | 67 | -0.0613593 | 0.0521063 | 0.2431934 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 104.9425 | 65 | 0.0012496 |
| Inverse variance weighted | 105.0331 | 66 | 0.0015971 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0003723 | 0.0015724 | 0.81356 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.3849866 | 0 | TRUE | 0 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
