Two sample MR report
mitochondrial CNV against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 49 | -0.1026418 | 0.0683787 | 0.1400241 |
| Weighted median | 49 | -0.0774741 | 0.0400977 | 0.0533431 |
| Inverse variance weighted | 49 | -0.0737902 | 0.0283830 | 0.0093277 |
| Simple mode | 49 | -0.0611050 | 0.0648327 | 0.3506550 |
| Weighted mode | 49 | -0.0611050 | 0.0524367 | 0.2496524 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 52.70731 | 47 | 0.2628589 |
| Inverse variance weighted | 52.94936 | 48 | 0.2890034 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0007197 | 0.0015491 | 0.6443754 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.3499172 | 0 | TRUE | 0 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
