Two sample MR report
39S ribosomal protein L32, mitochondrial against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | 0.0171017 | 0.0244786 | 0.5045769 |
| Weighted median | 10 | 0.0148652 | 0.0119880 | 0.2149729 |
| Inverse variance weighted | 10 | 0.0187746 | 0.0089049 | 0.0350014 |
| Simple mode | 10 | 0.0141822 | 0.0180719 | 0.4527537 |
| Weighted mode | 10 | 0.0144017 | 0.0181737 | 0.4484836 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.884262 | 8 | 0.8674118 |
| Inverse variance weighted | 3.889645 | 9 | 0.9185244 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.000282 | 0.0038431 | 0.9433148 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004986 | 0 | TRUE | 0.2043615 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
