Two sample MR report
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 17 | 0.0092348 | 0.0057650 | 0.1300303 |
| Weighted median | 17 | 0.0084746 | 0.0038362 | 0.0271675 |
| Inverse variance weighted | 17 | 0.0081960 | 0.0040046 | 0.0406929 |
| Simple mode | 17 | 0.0004400 | 0.0147135 | 0.9765149 |
| Weighted mode | 17 | 0.0081213 | 0.0039912 | 0.0587891 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 21.69418 | 15 | 0.1160773 |
| Inverse variance weighted | 21.79049 | 16 | 0.1500860 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0004746 | 0.001839 | 0.7998661 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.1243148 | 0 | TRUE | 0 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
