Two sample MR report
Steroidogenic acute regulatory protein, mitochondrial against Frailty index || id:ebi-a-GCST90020053
Date: 06 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 13 | 0.0415386 | 0.0221826 | 0.0879310 |
| Weighted median | 13 | 0.0144958 | 0.0106511 | 0.1735217 |
| Inverse variance weighted | 13 | 0.0218905 | 0.0092507 | 0.0179636 |
| Simple mode | 13 | 0.0077826 | 0.0188096 | 0.6863486 |
| Weighted mode | 13 | 0.0093443 | 0.0201736 | 0.6515132 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 18.45971 | 11 | 0.0715087 |
| Inverse variance weighted | 20.05485 | 12 | 0.0660555 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.004661 | 0.0047807 | 0.3505362 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0009495 | 0 | TRUE | 0.0805108 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
